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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Staphylococcus epidermidis colonization is highly clonal across US cardiac centers.

Abstract Source:

J Infect Dis. 2012 May 1 ;205(9):1391-8. Epub 2012 Mar 29. PMID: 22457291

Abstract Author(s):

Rachel J Gordon, Maria Miragaia, Alan D Weinberg, Caroline J Lee, Joana Rolo, Julie C Giacalone, Mark S Slaughter, Pat Pappas, Yoshifumi Naka, Alfred J Tector, Herminia de Lencastre, Franklin D Lowy

Article Affiliation:

Department of Medicine, Division of Infectious Diseases, Columbia University College of Physicians&Surgeons, New York, New York 10032, USA. rj216@columbia.edu

Abstract:

BACKGROUND: Little is known about the clonality of Staphylococcus epidermidis in the United States, although it is the predominant pathogen in infections involving prosthetic materials, including ventricular assist devices (VADs).

METHODS: Seventy-five VAD recipients at 4 geographically diverse US cardiac centers were prospectively followed up to 1 year of VAD support. The anterior nares, sternum, and (future) driveline exit site were cultured for S. epidermidis before VAD insertion and at 7 times after surgery. Infection isolates were also collected. Isolates were typed by pulsed-field gel electrophoresis. A subset underwent susceptibility testing and staphylococcal chromosomal cassette mec and multilocus sequence typing.

RESULTS: A total of 1559 cultures yielded 565 S. epidermidis isolates; 254 of 548 typed isolates (46%) belonged to 1 of 7 clonal types as defined by pulsed-field gel electrophoresis. These clones were identified in up to 27 people distributed across all 4 cardiac centers. They caused 3 of 6 VAD-related infections. Disseminated clones were more antibiotic resistant than were less prevalent isolates (eg, 79% vs 54% methicillin resistant; P = .0021).

CONCLUSIONS: This study revealed that healthcare-associated S. epidermidis infection is remarkably clonal. We describe S. epidermidis clones that are highly resistant to antibiotics distributed across US cardiac centers. These clones may have determinants that enhance transmissibility, persistence, or invasiveness. Clinical Trials Registration. NCT01471795.

Study Type : Bacterial

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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