Abstract Title:

Sucralose Promotes Food Intake through NPY and a Neuronal Fasting Response.

Abstract Source:

Cell Metab. 2016 Jul 12 ;24(1):75-90. PMID: 27411010

Abstract Author(s):

Qiao-Ping Wang, Yong Qi Lin, Lei Zhang, Yana A Wilson, Lisa J Oyston, James Cotterell, Yue Qi, Thang M Khuong, Noman Bakhshi, Yoann Planchenault, Duncan T Browman, Man Tat Lau, Tiffany A Cole, Adam C N Wong, Stephen J Simpson, Adam R Cole, Josef M Penninger, Herbert Herzog, G Gregory Neely

Article Affiliation:

Qiao-Ping Wang

Abstract:

Non-nutritive sweeteners like sucralose are consumed by billions of people. While animal and human studies have demonstrated a link between synthetic sweetener consumption and metabolic dysregulation, the mechanisms responsible remain unknown. Here we use a diet supplemented with sucralose to investigate the long-term effects of sweet/energy imbalance. In flies, chronic sweet/energy imbalance promoted hyperactivity, insomnia, glucose intolerance, enhanced sweet taste perception, and a sustained increase in food and calories consumed, effects that are reversed upon sucralose removal. Mechanistically, this response was mapped to the ancient insulin, catecholamine, and NPF/NPY systems and the energy sensor AMPK, which together comprise a novel neuronal starvation response pathway. Interestingly, chronic sweet/energy imbalance promoted increased food intake in mammals as well, and this also occurs through an NPY-dependent mechanism. Together, our data show that chronic consumption of a sweet/energy imbalanced diet triggers a conserved neuronal fasting response and increases the motivation to eat.

Study Type : Animal Study

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.