Sulfur deficiency may aggravate chromate toxicity. - GreenMedInfo Summary

Abstract Title:

Chromate toxicity and the role of sulfur.

Abstract Source:

Metallomics. 2011 Aug 1. Epub 2011 Aug 1. PMID: 21804974

Abstract Author(s):

Sara L Holland, Simon V Avery

Article Affiliation:

School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom. Simon.Avery@nottingham.ac.uk.

Abstract:

The molecular mode(s)-of-action of the toxic metal chromium has yet to be fully resolved. This Mini review focuses on interactions between chromate and sulfur in biological systems. Cr binds sulfur ligands, with cysteine and glutathione having the capacity to aggravate or ameliorate Cr toxicity. Competition between chromate and sulfate for uptake and in metabolism provokes sulfur starvation, which can be growth limiting. Recent data indicate that sulfur deficiency determines protein damage-related Cr toxicity, due to mRNA mistranslation caused by Cr-induced S limitation. Sulfur deprivation could contribute to additional aspects of Cr toxicity, including oxidative DNA damage and Cr related disease.

Pubmed Data : Metallomics. 2011 Aug 1. Epub 2011 Aug 1. PMID: 21804974
Article Published Date : Aug 01, 2011
Study Type : Animal Study
Additional Links
Diseases : Chromate(VI) Toxicity : CK(4) : AC(2), Sulfur Deficiency : CK(3) : AC(2)
Problem Substances : Chromate : CK(3) : AC(2)

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