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Abstract Title:

Melittin, a major peptide component of bee venom, and its conjugates in cancer therapy.

Abstract Source:

Cancer Lett. 2017 Aug 28 ;402:16-31. Epub 2017 May 20. PMID: 28536009

Abstract Author(s):

Islam Rady, Imtiaz A Siddiqui, Mohamad Rady, Hasan Mukhtar

Article Affiliation:

Islam Rady

Abstract:

Melittin (MEL), a major peptide component of bee venom, is an attractive candidate for cancer therapy. This agent has shown a variety of anti-cancer effects in preclinical cell culture and animal model systems. Despite a convincing efficacy data against variety of cancers, its applicability to humans has met with challenges due to several issues including its non-specific cytotoxicity, degradation and hemolytic activity. Several optimization approaches including utilization of nanoparticle based delivery of MEL have been utilized to circumvent the issues. Here, we summarize the current understanding of the anticancer effects of bee venom and MEL on different kinds of cancers. Further, we also present the available information for the possible mechanism of action of bee venom and/or MEL.

Study Type : Review
Additional Links
Pharmacological Actions : Chemotherapeutic : CK(397) : AC(152)

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Sayer Ji
Founder of GreenMedInfo.com

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