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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Simian virus 40 transformation, malignant mesothelioma and brain tumors.

Abstract Source:

Expert Rev Respir Med. 2011 Oct ;5(5):683-97. PMID: 21955238

Abstract Author(s):

Fang Qi, Michele Carbone, Haining Yang, Giovanni Gaudino

Article Affiliation:

University of Hawaii Cancer Center, Honolulu, HI, USA.

Abstract:

Simian virus 40 (SV40) is a DNA virus isolated in 1960 from contaminated polio vaccines, that induces mesotheliomas, lymphomas, brain and bone tumors, and sarcomas, including osteosarcomas, in hamsters. These same tumor types have been found to contain SV40 DNA and proteins in humans. Mesotheliomas and brain tumors are the two tumor types that have been most consistently associated with SV40, and the range of positivity has varied about from 6 to 60%, although a few reported 100% of positivity and a few reported 0%. It appears unlikely that SV40 infection alone is sufficient to cause human malignancy, as we did not observe an epidemic of cancers following the administration of SV40-contaminated vaccines. However, it seems possible that SV40 may act as a cofactor in the pathogenesis of some tumors. In vitro and animal experiments showing cocarcinogenicity between SV40 and asbestos support this hypothesis.

Study Type : Review

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Sayer Ji
Founder of GreenMedInfo.com

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Depression: 21st Century Solutions + The Dark Side of Wheat

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