"Synthesis and in vitro Efficacy Studies of Silver Carbene Complexes on Biosafety Level 3 Bacteria." - GreenMedInfo Summary

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Abstract Title:

Synthesis and in vitro Efficacy Studies of Silver Carbene Complexes on Biosafety Level 3 Bacteria.

Abstract Source:

Eur J Inorg Chem. 2009 May 1 ;2009(13):1739-1745. PMID: 20160993

Abstract Author(s):

Matthew J Panzner, Arpaporn Deeraksa, Alyssa Smith, Brian D Wright, Khadijah M Hindi, Aysegul Kascatan-Nebioglu, Alfredo G Torres, Barbara M Judy, Christine E Hovis, Julia K Hilliard, Rebekah J Mallett, Emily Cope, D Mark Estes, Carolyn L Cannon, Jeff G Leid, Wiley J Youngs

Article Affiliation:

Department of Chemistry, University of Akron, Akron, OH 44325-3601, USA.

Abstract:

A series of N-heterocyclic carbene silver complexes have been synthesized and tested against the select group of bio-safety level 3 bacteria Burkholderia pseudomallei, Burkholderia mallei, Bacillus anthracis, methicillin-resistant Staphylococcus aureus and Yersinia pestis. Minimal inhibitory concentrations, minimal bactericidal and killing assays demonstrated the exceptional efficacy of the complexes against these potentially weaponizable pathogens.

Article Published Date : May 01, 2009
Study Type : Bacterial
Additional Links
Substances : Silver Compouds : CK(1) : AC(1)
Diseases : Bacteria: Weaponized : CK(1) : AC(1), Bubonic Plague : CK(2) : AC(1), MRSA : CK(190) : AC(47)
Pharmacological Actions : Anti-Bacterial Agents : CK(970) : AC(316)

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