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Abstract Title:

Tamoxifen-Dependent Induction of AGR2 Is Associated with Increased Aggressiveness of Endometrial Cancer Cells.

Abstract Source:

Cancer Invest. 2017 Apr 12:1-12. Epub 2017 Apr 12. PMID: 28402678

Abstract Author(s):

Roman Hrstka, Jan Podhorec, Rudolf Nenutil, Lucia Sommerova, Joanna Obacz, Michal Durech, Jakub Faktor, Pavel Bouchal, Hana Skoupilova, Borivoj Vojtesek

Article Affiliation:

Roman Hrstka

Abstract:

Tamoxifen treatment in breast cancer patients is associated with increased risk of endometrial malignancies. Significantly, higher AGR2 expression was found in endometrial cancers that developed in women previously treated with tamoxifen compared to those who had not been exposed to tamoxifen. An association of elevated AGR2 level with myometrial invasion occurrence and invasion depth was also found. In vitro analyses identified a stimulatory effect of AGR2 on cellular proliferation. Although adverse tamoxifen effects on endometrial cells remain elusive, our work identifies elevated AGR2 as a candidate tamoxifen-dependent mechanism of action responsible for increased incidence of endometrial cancer.

Study Type : In Vitro Study

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