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Abstract Title:

Tanshinone IIA-mediated inhibition on miR-125b/STARD13 axis attenuates the stemness and enhances adriamycin sensitivity of breast cancer cells.

Abstract Source:

Biochimie. 2019 May 9. Epub 2019 May 9. PMID: 31078586

Abstract Author(s):

Xiaoman Li, Lufeng Zheng, Tao Xi

Article Affiliation:

Xiaoman Li

Abstract:

The roles of Tanshinone IIA in regulating the stemness of tumor cells remain unclear. This work aims to explore the roles and underlying mechanisms of Tanshinone IIA in breast cancer cell stemness. We found that Tanshinone IIA attenuated the stemness of breast cancer cells, evident by downregulating the expression of stemness markers, hindering the capacity of spheroid formation and decreasing the CD24/CD44sub-population in a concentration-dependent manner. Additionally, Tanshinone IIA enhanced adriamycin sensitivity and attenuated adriamycin resistance of breast cancer cells. Mechanistical studies found that Tanshinone IIA downregulated miR-125b level and upregulated its target gene STARD13 (StAR-related lipid transfer domain protein 13) level, thus inactivating the miR-125b/STARD13 axis, which had been previously confirmed to promote breast cancer progression by our group. Notably, miR-125b overexpression enhanced the stemness of breast cancer cells, and miR-125b overexpression or STARD13 knockdown impaired the inhibitory effects of Tanshinone IIA on the stemness of breast cancer cells. Therefore, our results suggest that Tanshinone IIA could attenuate the stemness of breast cancer cells via suppressing miR-125b/STARD13 axis.

Study Type : In Vitro Study

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