Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Targeting cancer vulnerabilities with high-dose vitamin C.

Abstract Source:

Nat Rev Cancer. 2019 May ;19(5):271-282. PMID: 30967651

Abstract Author(s):

Bryan Ngo, Justin M Van Riper, Lewis C Cantley, Jihye Yun

Article Affiliation:

Bryan Ngo

Abstract:

Over the past century, the notion that vitamin C can be used to treat cancer has generated much controversy. However, new knowledge regarding the pharmacokinetic properties of vitamin C and recent high-profile preclinical studies have revived interest in the utilization of high-dose vitamin C for cancer treatment. Studies have shown that pharmacological vitamin C targets many of the mechanisms that cancer cells utilize for their survival and growth. In this Opinion article, we discuss how vitamin C can target three vulnerabilities many cancer cells share: redox imbalance, epigenetic reprogramming and oxygen-sensing regulation. Although the mechanisms and predictive biomarkers that we discuss need to be validated in well-controlled clinical trials, these new discoveries regarding the anticancer properties of vitamin C are promising to help identify patient populations that may benefit the most from high-dose vitamin C therapy, developing effective combination strategies and improving the overall design of future vitamin C clinical trials for various types of cancer.

Study Type : Review

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Sayer Ji
Founder of GreenMedInfo.com

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Depression: 21st Century Solutions + The Dark Side of Wheat

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