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Abstract Title:

Treatment of toenail onychomycosis with 2% butenafine and 5% Melaleuca alternifolia (tea tree) oil in cream.

Abstract Source:

Trop Med Int Health. 1999 Apr;4(4):284-7. PMID: 10357864

Abstract Author(s):

T A Syed, Z A Qureshi, S M Ali, S Ahmad, S A Ahmad

Article Affiliation:

Department of Dermatology, University of California, San Francisco, USA. tasyed@itsa.ucsf.edu

Abstract:

The prevalence of onychomycosis, a superficial fungal infection that destroys the entire nail unit, is rising, with no satisfactory cure. The objective of this randomized, double-blind, placebo-controlled study was to examine the clinical efficacy and tolerability of 2% butenafine hydrochloride and 5% Melaleuca alternifolia oil incorporated in a cream to manage toenail onychomycosis in a cohort. Sixty outpatients (39 M, 21 F) aged 18-80 years (mean 29.6) with 6-36 months duration of disease were randomized to two groups (40 and 20), active and placebo. After 16 weeks, 80% of patients using medicated cream were cured, as opposed to none in the placebo group. Four patients in the active treatment group experienced subjective mild inflammation without discontinuing treatment. During follow-up, no relapse occurred in cured patients and no improvement was seen in medication-resistant and placebo participants.

Study Type : Human Study
Additional Links
Pharmacological Actions : Antifungal Agents : CK(234) : AC(146)

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Sayer Ji
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