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Abstract Title:

Delta-9-Tetrahydrocannabinol/Cannabidiol Oromucosal Spray (Sativex(®)): A Review in Multiple Sclerosis-Related Spasticity.

Abstract Source:

Drugs. 2017 Mar 14. Epub 2017 Mar 14. PMID: 28293911

Abstract Author(s):

Gillian M Keating

Article Affiliation:

Gillian M Keating

Abstract:

Delta-9-tetrahydrocannabinol (THC)/cannabidiol (CBD) oromucosal spray (THC/CBD, Sativex(®), nabiximols) is available in numerous countries worldwide for the treatment of multiple sclerosis (MS)-related moderate to severe spasticity in patients who have not responded adequately to other anti-spasticity medication and who demonstrate clinically significant improvement in spasticity-related symptoms during an initial trial of therapy. Twelve weeks' therapy with THC/CBD improved MS-related spasticity in patients with an inadequate response to other anti-spasticity agents who had undergone a successful initial trial of THC/CBD therapy, according to the results of a pivotal phase 3 trial. Improvements in spasticity were maintained in the longer term with THC/CBD with no evidence of dose tolerance, and results of real-world studies confirm the effectiveness of THC/CBD in everyday clinical practice. Improvements in health-related quality of life and activities of daily living werealso seen with THC/CBD. THC/CBD is generally well tolerated; adverse effects such as dizziness may occur whilst the THC/CBD dosage is being optimized. THC/CBD has low abuse potential and a low risk of psychoactive effects. In conclusion, THC/CBD oromucosal spray is a useful option for the treatmentof MS-related spasticity not completely relieved with current anti-spasticity medication.

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Sayer Ji
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