Abstract Title:

Thyroid autoantibodies in women with and without thyroid disorders in an iodine-replete area.

Abstract Source:

East Mediterr Health J. 2008 Mar-Apr;14(2):325-32. PMID: 18561724

Abstract Author(s):

A Aminorroaya, M Momenzadeh, S Hovsepian, S Haghighi, M Amini

Abstract:

To compare the prevalence of positive autoantibodies in patients with thyroid disorders and healthy subjects in an iodine-replete area of the Islamic Republic of Iran, we studied 930 women in a clinic-based study: 698 patients (286 hypothyroid, 140 hyperthyroid, 272 with simple goitre) and 232 healthy women. Serum thyroxine (T4), triiodothyronine (T3), thyroid stimulating hormone, and anti-thyroid antibodies were measured. Positive autoantibodies were detected in 75.5% of patients with hypothyroidism, 73.6% of those with hyperthyroidism, 48.9% of those with simple goitre and 35.8% of the control group (P < 0.001). Autoimmunity may have a role in the genesis of common thyroid disorders.

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