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Abstract Title:

Hepatoprotective activity of Tribulus terrestris extract against acetaminophen-induced toxicity in a freshwater fish (Oreochromis mossambicus).

Abstract Source:

In Vitro Cell Dev Biol Anim. 2011 Dec ;47(10):698-706. PMID: 21975853

Abstract Author(s):

P Kavitha, R Ramesh, G Bupesh, A Stalin, P Subramanian

Article Affiliation:

Department of Animal Science, Bharathidasan University, Tiruchirappalli 620 024, Tamil Nadu, India. kavithabio200481@gmail.com

Abstract:

The potential protective role of Tribulus terrestris in acetaminophen-induced hepatotoxicity in Oreochromis mossambicus was investigated. The effect of oral exposure of acetaminophen (500 mg/kg) in O. mossambicus at 24-h duration was evaluated. The plant extract (250 mg/kg) showed a remarkable hepatoprotective activity against acetaminophen-induced hepatotoxicity. It was judged from the tissue-damaging level and antioxidant levels in liver, gill, muscle and kidney tissues. Further acetaminophen impact induced a significant rise in the tissue-damaging level, and the antioxidant level was discernible from the enzyme activity modulations such as glutamate oxaloacetic transaminase, glutamate pyruvic transaminase, alkaline phosphatase, acid phosphatase, glucose-6-phosphate dehydrogenase, lactate dehydrogenase, superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione S-transferase, lipid peroxidase and reduced glutathione. The levels of all these enzymes have significantly (p < 0.05) increased in acetaminophen-treated fish tissues. The elevated levels of these enzymes were significantly controlled by the treatment of T. terrestris extract (250 kg/mg). Histopathological changes of liver, gill and muscle samples were compared with respective controls. The results of the present study specify the hepatoprotective and antioxidant properties of T. terrestris against acetaminophen-induced toxicity in freshwater fish, O. mossambicus.

Study Type : Animal Study
Additional Links
Problem Substances : Tylenol : CK(140) : AC(16)
Adverse Pharmacological Actions : Hepatotoxic : CK(335) : AC(96)

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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