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Depression: 21st Century Solutions + The Dark Side of Wheat

Article Publish Status: FREE
Abstract Title:

Environmental Exposure to Triclosan and Semen Quality.

Abstract Source:

Int J Environ Res Public Health. 2016 Feb ;13(2):224. Epub 2016 Feb 17. PMID: 26901211

Abstract Author(s):

Wenting Zhu, Hao Zhang, Chuanliang Tong, Chong Xie, Guohua Fan, Shasha Zhao, Xiaogang Yu, Ying Tian, Jun Zhang

Article Affiliation:

Wenting Zhu

Abstract:

Triclosan (2,4,4'-trichloro-2'-hydroxy-diphenyl ether, TCS) is widely used in personal care, household, veterinary and industrial products. It was considered as a potential male reproductive toxicant in previous in vitro and in vivo studies. However, evidence from human studies is scarce. Our study aims to investigate the relationship between TCS exposure and semen quality. We measured urinary TCS concentrations in 471 men recruited from a male reproductive health clinic. TCS was detected in 96.7% of urine samples, with a median concentration of 0.97 ng (mg·creatinine)(-1) (interquartile range, 0.41-2.95 ng (mg·creatinine)(-1)). A multiple linear regression analysis showed a negative association between natural logarithm (Ln) transformed TCS concentration (Ln-TCS) and Ln transformed number of forward moving sperms (adjusted coefficient β = -0.17; 95% confidence interval (CI) (-0.32, -0.02). Furthermore, among those with the lowest tertile of TCS level, Ln-TCS was negatively associated with the number of forward moving sperms (β = -0.35; 95% CI (-0.68, -0.03)), percentage of sperms with normal morphology (β = -1.64; 95% CI (-3.05, -0.23)), as well as number of normal morphological sperms, sperm concentration and count. Our findings suggest that the adverse effect of TCS on semen quality is modest at the environment-relevant dose in humans. Further studies are needed to confirm our findings.

Study Type : Human Study
Additional Links
Problem Substances : Triclosan : CK(13) : AC(8)

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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