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Depression: 21st Century Solutions + The Dark Side of Wheat

Abstract Title:

Triptolide induces cell apoptosis by targeting H3K4me3 and downstream effector proteins in KM3 multiple myeloma cells.

Abstract Source:

Curr Pharm Biotechnol. 2015 Sep 30. Epub 2015 Sep 30. PMID: 26420049

Abstract Author(s):

Lu Wen, Yan Chen, Ling Lan Zeng, Fei Zhao, Sha Yi, Li Jing Yang, Ben Ping Zhang, Jie Zhao, Zi Chu Zhao, Chun Zhang

Article Affiliation:

Lu Wen

Abstract:

As the principal active ingredient in the Chinese herb Tripterygium wilfordii Hook.F (TwHF), triptolide has been shown to have very strong antitumor properties. The trimethylation of lysine 4 on histone H3 (H3K4me3) has been proposed to promote gene expression, and the accumulation of H3K4me3 at the transcriptional start sites of oncogenes is involved in carcinogenesis. To identify the association between the reduction of H3K4me3 and the apoptosis of MM cells induced by triptolide, we investigated the global patterns of H3K4me3 occupancy in the MM cell genome. Combined analyses using ChIP-on-chip and western blotting showed that H3K4me3 were highly enriched on the gene promoters of c-Myc and VEGFA and were associated with the up-regulation of both genes. Treatment of KM3 cells with triptolide and siRNA targeting ASH2L reduced the expression of c-Myc and VEGFA. These results suggest that triptolide can down-regulate c-Myc and VEGFA expression by blocking the accumulation of H3K4me3 on their promoters,and thus play an important role in anti-MM mechanism.

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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