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Abstract Title:

Tualang Honey Protects against BPA-Induced Morphological Abnormalities and Disruption of ERα, ERβ, and C3 mRNA and Protein Expressions in the Uterus of Rats.

Abstract Source:

Evid Based Complement Alternat Med. 2015 ;2015:202874. Epub 2015 Dec 14. PMID: 26788107

Abstract Author(s):

Siti Sarah Mohamad Zaid, Normadiah M Kassim, Shatrah Othman

Article Affiliation:

Siti Sarah Mohamad Zaid

Abstract:

Bisphenol A (BPA) is an endocrine disrupting chemical (EDC) that can disrupt the normal functions of the reproductive system. The objective of the study is to investigate the potential protective effects of Tualang honey against BPA-induced uterine toxicity in pubertal rats. The rats were administered with BPA by oral gavage over a period of six weeks. Uterine toxicity in BPA-exposed rats was determined by the degree of the morphological abnormalities, increased lipid peroxidation, and dysregulated expression and distribution of ERα, ERβ, and C3 as compared to the control rats. Concurrent treatment of rats with BPA and Tualang honey significantly improved the uterine morphological abnormalities, reduced lipid peroxidation, and normalized ERα, ERβ, and C3 expressions and distribution. There were no abnormal changes observed in rats treated with Tualang honey alone, comparable with the control rats. In conclusion, Tualang honey has potential roles in protecting the uterus from BPA-induced toxicity, possibly accounted for by its phytochemical properties.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Cytoprotective : CK(190) : AC(94)
Problem Substances : Bisphenol A : CK(685) : AC(178)

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Sayer Ji
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