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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Turmeric extract inhibits apoptosis of hippocampal neurons of trimethyltin-exposed rats.

Abstract Source:

Bratisl Lek Listy. 2017 ;118(3):142-148. PMID: 28319408

Abstract Author(s):

S Yuliani, S Widyarini, Mustofa, G Partadiredja

Article Affiliation:

S Yuliani

Abstract:

OBJECTIVES: The aim of the present study was to reveal the possible antiapoptotic effect of turmeric (Curcuma longa Linn.) on the hippocampal neurons of rats exposed to trimethyltin (TMT).

BACKGROUND: Oxidative damage in the hippocampus can induce the apoptosis of neurons associated with the pathogenesis of dementiaMETHODS. The ethanolic turmeric extract and a citicoline (as positive control) solution were administered to the TMT-exposed rats for 28 days. The body weights of rats were recorded once a week. The hippocampal weights and imumunohistochemical expression of caspase 3 proteins in the CA1 and CA2-CA3 regions of the hippocampi were examined at the end of the experiment.

RESULTS: Immunohistochemical analysis showed that the injection of TMT increased the expression of caspase 3 in the CA1 and CA2-CA3 regions of hippocampus. TMT also decreased the body and hippocampal weights. Furthermore, the administration of 200 mg/kg bw dose of turmeric extract decreased the caspase 3 expression in the CA2-CA3 pyramidal neurons but not in the CA1 neurons. It also prevented the decrease of the body and hippocampal weights.

CONCLUSION: We suggest that the 200 mg/kg bw dose of turmeric extract may exert antiapoptotic effect on the hippocampal neurons of the TMT-exposed rats (Tab. 1, Fig. 3, Ref. 49).

Study Type : Animal Study

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Depression: 21st Century Solutions + The Dark Side of Wheat

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