Abstract Title:

Hypoglycemic effects of turmeric (Curcuma longa L. rhizomes) on genetically diabetic KK-Ay mice.

Abstract Source:

Biol Pharm Bull. 2005 May;28(5):937-9. PMID: 15863912

Abstract Author(s):

Minpei Kuroda, Yoshihiro Mimaki, Tozo Nishiyama, Tatsumasa Mae, Hideyuki Kishida, Misuzu Tsukagawa, Kazuma Takahashi, Teruo Kawada, Kaku Nakagawa, Mikio Kitahara

Abstract:

The turmeric (Curcuma longa L. rhizomes) EtOH extract significantly suppressed an increase in blood glucose level in type 2 diabetic KK-A(y) mice. In an in vitro evaluation, the extract stimulated human adipocyte differentiation in a dose-dependent manner and showed human peroxisome proliferator-activated receptor (PPAR)-gamma ligand-binding activity in a GAL4-PPAR-gamma chimera assay. The main constituents of the extract were identified as curcumin, demethoxycurcumin, bisdemethoxycurcumin, and ar-turmerone, which had also PPAR-gamma ligand-binding activity. These results indicate that turmeric is a promising ingredient of functional food for the prevention and/or amelioration of type 2 diabetes and that curcumin, demethoxycurcumin, bisdemethoxycurcumin, and ar-turmerone mainly contribute to the effects via PPAR-gamma activation.

Study Type : Animal Study

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