Two compounds found within white mustard seeds (Brassica alba), sinalbin and beta-sitosterol, have anti-androgen and anti-inflammation activities. - GreenMedInfo Summary

Abstract Title:

[An experimental study(II) on the inhibition of prostatic hyperplasia by extract of seeds of Brassica alba].

Abstract Source:

Zhongguo Zhong Yao Za Zhi. 2003 Jul;28(7):643-6. PMID: 15139111

Abstract Author(s):

Guo-xin Wu, Yue-xin Lin, Min-rui Ou, Dong-fei Tan

Abstract:

OBJECTIVE: To study the active components and their functionary mechanism of the extract of Brassica alba seeds, which inhibits experimental mice prostatic hyperplasia. METHOD: Prostatic hyperplasia of castrated male mice induced by testosterone propionate, the penetrability of capillary vessel of mice skin induced by histamine and the endermic flesh bud of rat induced by filter paper were used as experimental models. Sinalbin and beta-sitosterol separated from seeds of Brassica alba were used to test the activities. RESULT: Sinalbin and beta-sitosterol(16.0 mg.kg-1.d-1 and 8.0 mg.kg-1.d-1) could significantly inhibit mice prostatic hyperplasia induced by testosterone propionate and activity of serum acid phosphatase(P<0.01 or P<0.05), Sinalbin(16.0 mg.kg-1.d-1)could significantly inhibit the hyperplasia of endermic flesh bud in rat induced by filter paper(P<0.05), beta-sitosterol(16.0 mg.kg-1.d-1 and 8.0 mg.kg-1.d-1) could significantly decrease the penetrability of capillary vessel of mice skin induced by histamine. CONCLUSION: Sinalbin and beta-sitosterol have anti-androgen and anti-inflammation activities.

Article Published Date : Jul 01, 2003
Study Type : Animal Study
Additional Links
Substances : Beta Sitosterol : CK(43) : AC(14), Mustard: White : CK(4) : AC(2), Sinalbin : CK(2) : AC(1)
Diseases : Androgen-Induced Diseases : CK(49) : AC(20), Prostatic Hyperplasia: Benign : CK(202) : AC(46)
Pharmacological Actions : Anti-Androgen : CK(58) : AC(15)

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