Abstract Title:

Vanadyl sulfate ameliorates insulin resistance and restores plasma dehydroepiandrosterone-sulfate levels in fructose-fed, insulin-resistant rats.

Abstract Source:

Clin Biochem. 2004 Aug;37(8):694-7. PMID: 15302613

Abstract Author(s):

Mehdi Harati, Mohsen Ani

Article Affiliation:

Department of Biochemistry, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. [email protected]

Abstract:

OBJECTIVES: To elucidate whether vanadyl sulfate ameliorates the decreased dehydroepiandrosterone sulfate (DHEAS) in hyperinsulinemic rats, we evaluated plasma DHEAS, insulin and triglyceride (TG) levels in fructose-induced, insulin-resistant rats.

DESIGN AND METHODS: Animals were divided into three groups: control (C), fructose fed (F-F), and vanadyl-treated fructose fed (F-T). Control animals were fed with standard chow; F-F and F-T groups fed with 66% fructose diet. F-F and C groups received tap water; F-T group received water supplemented with 0.2 mg/ml vanadyl sulfate.

RESULTS: Fasting plasma glucose levels of three groups were comparable. Vanadyl treatment prevented the increase in plasma insulin and TG in the F-T group (P<0.001) compared with the F-F group. Fructose feeding led to a decrease in plasma DHEAS in the F-F group (P<0.001) compared with the C group. Vanadyl treatment prevented the decrease in plasma DHEAS in the F-T group (P<0.001) compared with the F-F group.

CONCLUSIONS: Our results indicated that the hyperinsulinemia in fructose-fed, insulin-resistant rats is associated with low levels of DHEAS. Vanadyl sulfate probably restores plasma DHEAS, due to the improved insulin action.

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.