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Abstract Title:

Stereological study on the effect of vitamin C in preventing the adverse effects of bisphenol A on rat ovary.

Abstract Source:

Int J Reprod Biomed (Yazd). 2016 Jun ;14(6):403-10. PMID: 27525324

Abstract Author(s):

Malek Soleimani Mehranjani, Tayebeh Mansoori

Article Affiliation:

Malek Soleimani Mehranjani

Abstract:

BACKGROUND: Bisphenol A (BPA), an environmental pollutant, can generate free radicals which damages the reproductive system. Vitamin C is an antioxidant which may prevent the adverse effects of free radicals.

OBJECTIVE: The aim was to investigate the effect of vitamin C on the ovary tissue in rats treated with BPA.

MATERIALS AND METHODS: In this experimental study, 24 female Wistar rats (200±20 gr) were randomly divided into 4 groups (n=6): control, BPA (60 µg/Kg/day), vitamin C (150 mg/Kg/day) and BPA + vitamin C and orally treated for 20 days. The left ovaries were taken out, fixed for tissue processing and studied using stereological methods. Data were analyzed with SPSS using one-way ANOVA, and the means were considered significantly different at (p<0.05).

RESULTS: The total volume of ovary and cortex (p<0.01), medulla (p<0.05), the volume of corpus luteum (p<0.001) and the mean number of antral follicles (p<0.001) significantly reduced in BPA group compared with control, while the number of atretic follicles increased (p<0.05). The volume of oocyte (p<0.01) and its nucleus (p<0.001) in the antral follicles and the thickness of zona pellucida (ZP) in the secondary (p<0.05) and antral (p<0.001) follicles significantly decreased in BPA group compared with controls. The above parameters in the BPA + vitamin C group were compensated to control level.

CONCLUSION: Vitamin C can be used as a potential antioxidant in the case of BPA toxication.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Antioxidants : CK(8430) : AC(3132)
Problem Substances : Bisphenol A : CK(685) : AC(178)

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Sayer Ji
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