Vitamin C regulates hematopoietic stem cell function and suppresses leukemogenesis by modulating Tet2 activity. - GreenMedInfo Summary

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Abstract Title:

Vitamin C: C-ing a New Way to Fight Leukemia.

Abstract Source:

Cell Stem Cell. 2017 Nov 2 ;21(5):561-563. PMID: 29100007

Abstract Author(s):

Katharina Schönberger, Nina Cabezas-Wallscheid

Article Affiliation:

Katharina Schönberger

Abstract:

Metabolic cues and (epi-)genetic factors are emerging regulators of hematopoietic stem cell (HSC) potency. Two new studies in Nature and Cell, from Agathocleous et al. (2017) and Cimmino et al. (2017), respectively, show that vitamin C regulates HSC function and suppresses leukemogenesis by modulating Tet2 activity.

Article Published Date : Nov 01, 2017
Study Type : Review
Additional Links
Substances : Vitamin C : CK(5869) : AC(1375)
Diseases : Leukemia : CK(1709) : AC(871)
Pharmacological Actions : Antiproliferative : CK(6801) : AC(6958)
Additional Keywords : Epigenetic Modification In Cancer : CK(188) : AC(125), Hematopoietic Stem Cells : CK(19) : AC(7)

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Key Research Topics

Substance

Vitamin C

Disease

Leukemia

Pharmacological Actions

Antiproliferative

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