Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get two FREE E-Books

Our newsletter serves 250,000 with essential news, research & healthy tips, daily.

Easy Turmeric recipes + The Dark Side of Wheat

Abstract Title:

Effects of vitamin D on serum lipid profile in patients with type 2 diabetes: A meta-analysis of randomized controlled trials.

Abstract Source:

Clin Nutr. 2016 Mar 15. Epub 2016 Mar 15. PMID: 27020528

Abstract Author(s):

Tina Jafari, Aziz A Fallah, Afshin Barani

Article Affiliation:

Tina Jafari

Abstract:

BACKGROUND & AIMS: The effect of vitamin D on lipid profile in type 2 diabetic patients is controversial. This meta-analysis aimed to assess the effect of vitamin D on serum total cholesterol (TC), triglycerides (TG), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) of these patients to elucidate the subject.

METHODS: Seven databases were searched and randomized controlled trials (RCTs) assessed the effect of vitamin D on lipid profile published until November 2015 were identified. Un-standardized mean difference and its corresponding 95% confidence interval (CI) was calculated from the effect sizes by using random effects model.

RESULTS: We found 2220 articles in our systematic search, after exclusion of un-related studies we enrolled 17 studies comparing intervention group (received vitamin D) with control group (received placebo) in the meta-analysis. Vitamin D significantly reduced serum TC (-3.74 mg/dl, 95% CI: -7.13 to -0.34, P = 0.031), but serum TG did not show significant reduction (-4.90 mg/dl, 95% CI: -15.11-5.31, P = 0.347). Results confirmed the significant lowering effect of vitamin D on LDL in patients with T2D (-2.55 mg/dl, 95% CI: -4.83 to -0.26, P = 0.029), but change in serum HDL was negligible (-0.72 mg/dl, 95% CI: -1.27 to -0.17, P = 0.010). Subgroup analyses showed that the baseline serum 25-hydroxy vitamin D of patients, vitamin D dosage, intervention duration, and the method of vitamin D application influence the effect of vitamin D on lipid markers.

CONCLUSION: This study demonstrated that vitamin D improved serum levels of TC, TG, and LDL in patients with T2D but changes of serum HDL was not satisfactory.

Study Type : Meta Analysis

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get two FREE E-Books

Our newsletter serves 250,000 with essential news, research & healthy tips, daily.

Easy Turmeric recipes + The Dark Side of Wheat

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2017 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.