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Abstract Title:

In Vitro Antibacterial Activity of Pomegranate Juice and Peel Extracts on Cariogenic Bacteria.

Abstract Source:

Biomed Res Int. 2017 ;2017:2152749. Epub 2017 Oct 25. PMID: 29209624

Abstract Author(s):

Gianmaria Fabrizio Ferrazzano, Elisa Scioscia, Daniela Sateriale, Gabiria Pastore, Roberta Colicchio, Chiara Pagliuca, Tiziana Cantile, Brunella Alcidi, Marco Coda, Aniello Ingenito, Elena Scaglione, Annunziata Gaetana Cicatiello, Maria Grazia Volpe, Michele Di Stasio, Paola Salvatore, Caterina Pagliarulo

Article Affiliation:

Gianmaria Fabrizio Ferrazzano

Abstract:

Aim: To evaluate the antimicrobial activity of hydroalcoholic extracts of pomegranate (Punica granatum L.) peel and juice, against the microorganisms considered the main etiologic agents of dental caries.

Methods: The values of the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) were determined against Streptococcus mutans Clarke ATCC® 25175™ strain and Rothia dentocariosa clinical isolate.

Results: Peel extracts inhibit effectively the growth and survival of S. mutans ATCC 25175 strain and R. dentocariosa clinical isolate with MIC and MBC values of 10 μg/μl and 15 μg/μl, respectively. Furthermore, the pomegranate juice extract showed high inhibitory activity against S. mutans ATCC 25175 strain with a MIC value of 25 μg/μl and a MBC value of 40 μg/μl, whereas, against R. dentocariosa, it has displayed a moderate inhibitory activity, with MIC and MBC values of 20 μg/μl and 140 μg/μl, respectively.

Conclusions: In vitro microbiological tests demonstrate that the hydroalcoholic extracts of pomegranate juice and peel are able to contrast the main cariogenic bacteria involved in tooth decay. Although being preliminary data, our results suggest that pomegranate polyphenolic compounds could represent a good adjuvant for the prevention and treatment of dental caries.

Study Type : In Vitro Study

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Sayer Ji
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