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Abstract Title:

In vitro anticancer activity of fucoidan from Turbinaria conoides against A549 cell lines.

Abstract Source:

Int J Biol Macromol. 2015 Jan ;72:919-23. Epub 2014 Oct 16. PMID: 25451746

Abstract Author(s):

Thangapandi Marudhupandi, Thipramalai Thankappan Ajith Kumar, Shanmugaasokan Lakshmanasenthil, Gunasekaran Suja, Thirumalairaj Vinothkumar

Article Affiliation:

Thangapandi Marudhupandi

Abstract:

The present study was conducted to evaluate the anticancer activity of fucoidan isolated from brown seaweed Turbinaria conoides. Extracted fucoidan contained 53± 0.69% of fucose and 38 ± 0.42% of sulphate, respectively. Functional groups and structural characteristics of the fucoidan were analyzed by FT-IR and NMR. In vitro anticancer effect was studied on A549 cell line. Fucoidan inhibited the growth of cancer cells in a dose-dependent manner and potentanticancer activities were 24.9-73.5% in the concentrations of 31.25-500 μg/ml. The CTC50 value against the cancer cell was found to be 45 μg/ml and the CTC50 value of normal Vero cell line is 325 μg/ml. This study suggests that the fucoidan from T. conoides could be significantly improved if the active component is further purified and tested for further investigation in various cancer cell lines.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Chemotherapeutic : CK(2328) : AC(1407)

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