In vitro anticancer activity of fucoidan from Turbinaria conoides against A549 cell lines. - GreenMedInfo Summary
In vitro anticancer activity of fucoidan from Turbinaria conoides against A549 cell lines.
Int J Biol Macromol. 2015 Jan ;72:919-23. Epub 2014 Oct 16. PMID: 25451746
Thangapandi Marudhupandi
The present study was conducted to evaluate the anticancer activity of fucoidan isolated from brown seaweed Turbinaria conoides. Extracted fucoidan contained 53± 0.69% of fucose and 38 ± 0.42% of sulphate, respectively. Functional groups and structural characteristics of the fucoidan were analyzed by FT-IR and NMR. In vitro anticancer effect was studied on A549 cell line. Fucoidan inhibited the growth of cancer cells in a dose-dependent manner and potentanticancer activities were 24.9-73.5% in the concentrations of 31.25-500 μg/ml. The CTC50 value against the cancer cell was found to be 45 μg/ml and the CTC50 value of normal Vero cell line is 325 μg/ml. This study suggests that the fucoidan from T. conoides could be significantly improved if the active component is further purified and tested for further investigation in various cancer cell lines.