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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Protective Effect of Juglans regia L. Walnut Extract Against Oxidative DNA Damage.

Abstract Source:

Plant Foods Hum Nutr. 2017 Apr 11. Epub 2017 Apr 11. PMID: 28401378

Abstract Author(s):

Cinzia Calcabrini, Roberta De Bellis, Umberto Mancini, Luigi Cucchiarini, Vilberto Stocchi, Lucia Potenza

Article Affiliation:

Cinzia Calcabrini

Abstract:

Walnuts (Juglans regia L.) are relevant components of the Mediterranean diet providing important macronutrients, micronutrients and other bioactive constituents including unsaturated fatty acids, proteins, fiber, vitamins, minerals, phytosterols and polyphenols. Although the walnut beneficial effects in human health are widely recognized by a lot of epidemiologic studies very little is known regarding its effect on damaged DNA. The aim of the present study was to investigate the effect of Juglans regia L. ethanolic extract from kernel on the induction of DNA strand breaks by thiol/Fe(3+)/O2 mixed function oxidase, tert-butyl hydroperoxide or UVC radiations in acellular and cellular models. Plasmid DNA cleavage and fast Halo assay were used to monitor oxidative damage to DNA. Both approaches showed protection of oxidatively injured DNA. These results agree with a lot of scientific proofs which recommend walnut as dietary adjunct in health promotion and prevention as well as in treatment of lifestyle-related oxidative diseases.

Study Type : In Vitro Study

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Sayer Ji
Founder of GreenMedInfo.com

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Depression: 21st Century Solutions + The Dark Side of Wheat

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