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Abstract Title:

Features of whey protein concentrate supplementation in children with rapidly progressive HIV infection.

Abstract Source:

J Trop Pediatr. 2006 Feb;52(1):34-8. Epub 2005 Jul 13. PMID: 16014759

Abstract Author(s):

Y F Moreno, V C Sgarbieri, M N da Silva, A A D C Toro, M M S Vilela

Article Affiliation:

Center for Investigation in Pediatrics (CIPED), Pediatrics Department, and Food and Nutrition Department, Food Engineering School, State University of Campinas, São Paulo, Brazil.

Abstract:

HIV infection is associated with subnormal GSH levels. An increase in glutathione levels has been observed in HIV-infected adults under oral whey protein supplementation. We studied the features associated with a whey protein concentrate supplementation in children with rapidly progressive AIDS. A prospective double-blind clinical trial was carried out for 4 months with 18 vertically HIV-infected children (1.98-6.37 years), under antiretroviral therapy, who had received whey protein, maltodextrin (placebo) or none. Erythrocyte glutathione concentration, T lymphocyte counts (CD4+ and CD8+) and occurrence of associated co-infections were evaluated. Wilcoxon's and Fischer's Exact tests were used to assess differences between whey protein-supplemented and control (placebo and non-supplemented) groups. A significant median increase of 16.14 mg/dl (p = 0.018) in erythrocyte glutathione levels was observed in the whey protein-supplemented group; the TCD4/CD8 lymphocyte ratio showed a non significant increase and lower occurrence of associated co-infections was also observed. In conclusion, whey protein concentrate supplementation can stimulate glutathione synthesis and, possibly, decrease the occurrence of associated co-infections.

Study Type : Human Study

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