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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Xanthohumol, a novel anti-HIV-1 agent purified from Hops Humulus lupulus.

Abstract Source:

Antiviral Res. 2004 Dec ;64(3):189-94. PMID: 15550272

Abstract Author(s):

Qian Wang, Zhi-Hui Ding, Ji-Kai Liu, Yong-Tang Zheng

Article Affiliation:

Qian Wang

Abstract:

Xanthohumol, prenylchacone flavonoid, is a natural product with multi-biofunctions purified from Hops Humulus lupulus. Its anti-HIV-1 activity was tested in the present study. Results showed that xanthohumol inhibited HIV-1 induced cytopathic effects, the production of viral p24 antigen and reverse transcriptase in C8166 lymphocytes at non-cytotoxic concentration. The EC50 values were 0.82, 1.28 and 0.50 microg/ml, respectively. The therapeutic index (TI) was about 10.8. Xanthohumol also inhibited HIV-1 replication in PBMC with EC50 value of 20.74 microg/ml. The activity of recombinant HIV-1 reverse transcriptase and the HIV-1 entry were not inhibited by xanthohumol. The results from this study suggested that xanthohumol is effective against HIV-1 and might serve as an interesting lead compound. It may represent a novel chemotherapeutic agent for HIV-1 infection. However, the mechanism of its anti-HIV-1 effect needs to be further clarified.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Anti-HIV Agents : CK(111) : AC(63)

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Sayer Ji
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Depression: 21st Century Solutions + The Dark Side of Wheat

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