Abstract Title:

[Clinical effect of Yisui decoction plus western medicine in treating multiple system atrophy].

Abstract Source:

Zhongguo Zhong Yao Za Zhi. 2014 Aug ;39(15):2968-71. PMID: 25507564

Abstract Author(s):

Pei-Ran Zhang, Gai-Hui Guo, Wei-Hong Gu, Zi-Yi Zhang, Kang Wang, Miao Jin

Article Affiliation:

Pei-Ran Zhang

Abstract:

To observe the clinical effect of Yisui decoction plus western medicine in treating multiple system atrophy patients, totally 65 patients from China-Japan Friendship hospital during 2008-2012 with complete clinical data and received consecutive traditional Chinese medicine and western medicine treatment for more than 3 months were observed changes of traditional Chinese medicine symptom score, part 1 of unified multiple system atrophy rating scale, orthostatic hypotension before treatment and after 3 months treatment. After 3 months treatment, total effective rate of traditional Chinese medicine symptom was 70.8%. Compared with before treatment, score of part 1 of unified multiple system atrophy rating scale was obviously reduced after 3 month treatment (P<0.001). Ex- cept swallow function without significant improvement, the remaining projects of unified multiple system atrophy rating scale were im- proved obviously (P<0.05), of which the most obvious differences were orthostatic symptoms, falls and intestinal function (P<0.001). Orthostatic hypotension after 1 month treatment and 3 month treatment was obviously better than before treatment (P<0.001). There was no significant difference in orthostatic hypotension between 1 month treatment and 3 month treatment. The research results show that Yisui decoction plus western medicine has a certain effect on improving clinical symptoms of multiple system atrophy patients, especially has a significant effect on orthostatic hypotension, and can maintain a stable clinical effect in a certain period of time.

Study Type : Human Study

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