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Depression: 21st Century Solutions + The Dark Side of Wheat

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Abstract Title:

Effect of Zataria multiflora extract on total and differential white blood cell count and endothelin level in blood of ovalbumin sensitized guinea pigs.

Abstract Source:

Chin J Integr Med. 2016 Jan 29. Epub 2016 Jan 29. PMID: 26825085

Abstract Author(s):

Mohammad Hossein Boskabady, Sediqeh Jalali

Article Affiliation:

Mohammad Hossein Boskabady

Abstract:

OBJECTIVE: To investigate the effect of hydro-ethanolic extract of Zataria multiflfl ora (Z. multiflflora) on endothelin level, total and differential white blood cells (WBC) count of sensitized guinea pigs.

METHODS: Five groups of guinea pigs sensitized to ovalbumin (OA) were given drinking water alone (group S), drinking water containing three concentrations of Z. multiflflora (0.2, 0.4 and 0.8 mg/mL as groups S+Z1, S+Z2 and S+Z3) and dexamethasone (group S+D), n=6 for each group. The endothelin levels as well as total and differential WBC count in blood of sensitized and control guinea pigs were evaluated using enzyme linked immunosorbent assay method, and hemocytometer and Wright-Giemsa's staining of blood sample smear respectively.

RESULTS: Blood endothelin levels, total and most differential WBC count were increased but lymphocytes decreased in sensitized animals compared to controls (allP<0.01). In groups S+D, S+Z2 and S+Z3 endothelin level, total and differential WBC counts were signifificantly improved compared with group S (P<0.01). Although, all measured parameters in group S+Z1 was lower than group S+D (P<0.01), some parameters in group S+Z3 were greater than in group S+D (P<0.05 toP<0.01).

CONCLUSION: The results showed an anti-inflflammatory effect of Z. multiflflora extract in sensitized guinea pigs, which may suggest a therapeutic potential for the plant on asthma.

Study Type : Animal Study

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Depression: 21st Century Solutions + The Dark Side of Wheat

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