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Abstract Title:

Induction of apoptosis by zerumbone isolated from Zingiber zerumbet (L.) Smith in protozoan parasite Leishmania donovani due to oxidative stress.

Abstract Source:

Braz J Infect Dis. 2016 Jan-Feb;20(1):48-55. Epub 2015 Nov 28. PMID: 26643969

Abstract Author(s):

Debarati Mukherjee, Chingakham Brajakishor Singh, Somaditya Dey, Supratim Mandal, Joydip Ghosh, Suvadip Mallick, Aabid Hussain, Ningombam Swapana, Samir Anis Ross, Chiranjib Pal

Article Affiliation:

Debarati Mukherjee

Abstract:

In the present context of emergence of resistance aligned with the conventional anti-leishmanial drugs and occasional treatment failure compelled us to continue the search for replaceable therapeutic leads against Leishmania infection. Various ginger spices of the Zingiberaceae family are widely used as spices, flavouring agents, and medicines in Southeast Asia because of their unique flavour as well as due to their medicinal properties. Zerumbone, a natural component of Zingiber zerumbet (L.) Smith, has been studied for its pharmacological potential as antiulcer, antioxidant, anticancer, and antimicrobial. In this study, we have shown that zerumbone could induce ROS mediated apoptosis in Leishmania donovani promastigotes and also found effective in reducing intracellular amastigotes in infected-macrophages. We emphasized the potential of zerumbone to be employed in the development of new therapeutic drugs against L. donovani infection and provided the basis for future research on the application of transitional medicinal plants.

Study Type : In Vitro Study

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