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Wheat: 200 Clinically Confirmed Reasons Not To Eat It

200 Clinically Confirmed Reasons Not To Eat Wheat

With sales of foods labeled gluten free now reaching over 6 billion dollars a year, something truly profound is happening to the way in which Americans are perceiving the role of wheat in their diets. Once celebrated as the very poster-child of the health food movement, folks are increasingly rejecting this "king of grains," and are now identifying it as being at the very root of their health problems.

Detractors claim that the movement is just a fad, or worse, that those who have embarked upon it without an official diagnosis are a bit crazy. After all, simply "feeling better" following gluten elimination is not considered to be proof of anything within the conventional medical system.  Biopsies, antibody, and genetic tests later, if nothing is found, and you still think gluten – this 'sacred,' omnipresent grain – is a problem, you might just get referred to a psychiatrist.

But anecdotes and "subjective experience" aside, the type of clinical research that constitutes "Truth," with a capital T, from the perspective of the dominant medical establishment, can be found on the National Library of Medicine's biomedical database known as MEDLINE. This vast bibliographic archive contains over 21 million citation entries, which as of time of this writing, contains 9,776 references to gluten

There has been a sharp increase in interest and research on the topic of "gluten intolerance" – although we prefer to label the subject "gluten toxicity," in order to shift the focus away from the "victim" back to the "aggressor," the gluten itself. In 1971, there were 71 studies listed on MEDLINE which referenced gluten. Last year in 2011, there were 514.  

One of our many interests here at is to identify "Problem Substances," which is why we have created an index by that name with 698 subjects listed from A-Z.  If you navigate to WHEAT under the "W's" you will find a list under "Advanced Topics" with 205 health conditions and/or adverse health effects associated with wheat consumption, all of which were determined solely through research in peer-reviewed and published medical journals indexed on MEDLINE.

You will also find, below the listed diseases, a "pharmacological actions" field set which lists 20 distinct ways in which wheat harms the body, e.g. nerve-damaging (neurotoxic), immune-damaging (immunoreactive), inflammatory, etc.

At present, the conventional medical establishment only identifies a handful of disorders likely to be caused by wheat consumption, such as:

  • Wheat Allergy
  • Celiac Disease
  • Dermatitis Herpetiformis
  • Exercise-Induced Wheat Anaphylaxis

These conditions, however, are but the tip of a massive "celiac" iceberg.  In a previous essay, The Dark Side of Wheat, we discussed the problem from a more philosophical perspective.  There is now, however, a huge dataset firmly establishing the likelihood that wheat intolerance, or better yet, wheat toxicity, is a universal, human species-specific problem, occurring only in differing degrees, and mostly sub-clinically, at least through the optic of conventional screenings and technologies.

One must also account for the "invisible thorn," which is wheat lectin – known more technically as Wheat Germ Agglutinin (WGA) -- and which can cause a broad range of adverse health effects, even while being undetected through conventional screenings.  Learn more about this topic in our essay Opening Pandora's Bread Box: The Critical Role of Wheat Lectin in Human Disease.

In order to fully appreciate the extent of damage wheat and/or gluten consumption can have on the body, included "sprouted wheat" (since WGA is still present), view the screenshot from our Wheat page below:

Quick Summary: 205 associated Diseases
Name Cumulative Knowledge Article Count Focus Articles
Celiac Disease 1395 150 focus
Wheat Intolerance 402 29 focus
Gluten Sensitivity 380 35 focus
Gluten Intolerance 336 27 focus
Autoimmune Diseases 136 12 focus
Schizophrenia 111 7 focus
Food Allergies: Wheat 106 11 focus
Food Allergies 97 10 focus
Psoriasis 82 5 focus
Down Syndrome 80 5 focus
Diabetes Mellitus: Type 1 73 12 focus
Irritable Bowel Syndrome 71 4 focus
Diabetes Mellitus: Type 1: Prevention 70 8 focus
Celiac Disease: Diagnostic Considerations 63 7 focus
Autism Spectrum Disorders 61 5 focus
Sjogren's Syndrome 60 3 focus
Cerebellar Ataxia 53 4 focus
Dermatitis Herpetiformis 50 4 focus
Epilepsy 50 6 focus
Graves Disease 50 3 focus
Liver Disease 50 2 focus
Multiple Myeloma 50 3 focus
Multiple Sclerosis 50 3 focus
Migraine Disorders 44 5 focus
Atopic Dermatitis 40 4 focus
Casein Intolerance 40 2 focus
Gastroesophageal Reflux 40 2 focus
Hyperthyroidism 40 2 focus
Anaphylaxis: Exercise-Induced 37 5 focus
IgA Nephropathy 36 3 focus
Gastrointestinal Inflammation 34 5 focus
Infertility 31 2 focus
Autoimmune Thyroiditis 30 2 focus
Cirrhosis: Liver 30 1 focus
Diarrhea: IBS associated 30 1 focus
Hypothyroidism 30 3 focus
IgA rheumatoid factor: elevated 30 2 focus
Infertility: Female 30 1 focus
Non-Hodgkin Lymphoma 30 3 focus
Polyarthritis 30 1 focus
Psychoses 30 1 focus
Eosinophilic esophagitis 26 4 focus
Epilepsy: With Cerebral Calcifications 25 3 focus
Cerebral Calcifications 23 2 focus
Diarrhea 23 3 focus
Celiac Disease: Prevention 22 2 focus
Abortion: Spontaneous 21 2 focus
Ataxia: Cerebellar 21 3 focus
Miscarriage: Recurrent 21 2 focus
Thyroid Nodule 21 2 focus
Atherosclerosis 20 1 focus
Attention Deficit Disorder with Hyperactivity 20 2 focus
Attention Deficit Hyperactivity Disorder 20 1 focus
Autism 20 1 focus
Cardiomyopathy 20 1 focus
Cholestasis 20 1 focus
Cholestasis: Autoimmune 20 1 focus
Coronary Artery Disease 20 1 focus
End-Stage Autoimmune Liver Disease (ESALD) 20 1 focus
Hashimoto's thyroiditis 20 1 focus
IgE-Mediated Hypersensitivity 20 2 focus
Infant Nutrition 20 1 focus
Meniere's Disease 20 1 focus
Organ Transplantation: Liver 20 1 focus
Palmoplantar Pustulosis 20 1 focus
Peripheral Neuropathies 20 1 focus
Restless Legs Syndrome 20 2 focus
Rett Syndrome 20 1 focus
Sensory Neuropathies 20 1 focus
Macroamylasemia 19 4 focus
Intestinal Permeability 17 6 focus
Asthma 15 4 focus
Ataxia 14 3 focus
Headache 13 2 focus
Pancreatitis 13 2 focus
Lymphoma 12 2 focus
Psychiatric Disorders 12 2 focus
Cancers: All 11 2 focus
Rheumatoid Arthritis 11 2 focus
Thyroid Cancer 11 2 focus
Acquired hypogammaglobulinemia 10 1 focus
Allergy: Cow's Milk 10 1 focus
Anaphylaxis 10 1 focus
Aphthous Ulcer 10 1 focus
Ataxia: Dominant 10 1 focus
Ataxia: Sporadic 10 1 focus
Atopic Dermatitis: Infant & Childhood 10 1 focus
Attention Deficit Disorder 10 1 focus
Brain Injury: Hippocampal Damage 10 1 focus
CNS White Matter Abnormalities 10 1 focus
Carpal Tunnel Syndrome 10 1 focus
Celiac Disease: Early Onset 10 1 focus
Child Mortality 10 1 focus
Children: Impaired Growth 10 1 focus
Chronic Constipation, Children 10 1 focus
Colitis: Collagenous 10 1 focus
Constipation 10 1 focus
Depression: Unipolar 10 1 focus
Diarrhea: in Children 10 1 focus
Enamel Defects 10 1 focus
Epithelium Damage: Lymphocytic infiltration 10 1 focus
Food Allergies/Intolerances: Cereals/Grains 10 1 focus
Gastrointestinal Hemorrhage 10 1 focus
Gluten Ataxia 10 1 focus
Hepatitis: Autoimmune 10 1 focus
Hippocampal Sclerosis 10 1 focus
Hypertransaminasemia 10 1 focus
Hypogammaglobulinemia 10 1 focus
Kidney Cancer 10 1 focus
Liver Fibrosis 10 1 focus
Mania: Acute 10 1 focus
Microscopic Colitis Syndrome 10 1 focus
Mortality: All-Cause 10 1 focus
Mucosa: Flattened 10 1 focus
Myocarditis: Autoimmune 10 1 focus
Myopathies 10 1 focus
Myopathies: Inflammatory 10 1 focus
Nervous System Diseases 10 1 focus
Neurological Illness: GAD antibody-associated 10 1 focus
Nightshade Foods Intolerance 10 1 focus
Pregnancy: Prevention of Problems 10 1 focus
Small-for-gestational-age infant 10 1 focus
Spinocerebellar Ataxia Type 2 10 1 focus
Stiff-Person Syndrome 10 1 focus
Stomatitis: Aphthous 10 1 focus
Temporal Lobe Epilepsy (TLE) 10 1 focus
Thyroid Neoplasms 10 1 focus
Turner Syndrome 10 1 focus
Urinary Stone Disease 10 1 focus
Kidney Diseases 9 2 focus
Prolactin: Inappropriate Secretion 8 2 focus
Anemia 7 2 focus
Conjunctival Tumor 6 1 focus
Ectopic Calcification 6 1 focus
Encephalopathies 6 1 focus
Glomerulonephritis 6 1 focus
Hypocalcemia 6 1 focus
Neuromyelitis Optica 6 2 focus
Pituitary Diseases 6 1 focus
Polyneuropathies 6 1 focus
Prolactin Hypersecretion Syndrome 6 2 focus
Seizures 6 1 focus
Splenic Calcifications 6 1 focus
Splenic Diseases 6 1 focus
Systemic Lupus Erythematosus 6 1 focus
Urticaria 6 2 focus
Immune Disorders: Low Immune Function 5 1 focus
Malabsorption Syndrome 5 2 focus
Enteropathy 4 2 focus
Insulin: Elevated 4 2 focus
Male Hormone Imbalances 4 1 focus
Diabetes Mellitus: Type 2 3 1 focus
Facial Palsy 3 1 focus
Folic Acid/Folate Deficiency 3 1 focus
Food Allergy: Immunoglobulin E-mediated 3 1 focus
Gastrointestinal Diseases 3 2 focus
Hydronephrosis 3 1 focus
Hyperamylasemia 3 1 focus
Inflammation 3 2 focus
Insulin Disorders 3 2 focus
Kidney Stones 3 1 focus
Opiate Addiction/Withdrawal 3 1 focus
Osteogenesis Imperfecta 3 1 focus
Osteomalacia 3 1 focus
Osteopenia 3 1 focus
Osteoporosis 3 1 focus
Parathyroid Diseases 3 1 focus
Parathyroid adenoma 3 1 focus
Stroke 3 1 focus
Thrombosis 3 1 focus
Tremor 3 1 focus
Urolithiasis 3 1 focus
Uveitis 3 1 focus
A1C 2 1 focus
Allergies 2 1 focus
Blood-Brain-Barrier Disorders 2 2 focus
Demyelinating Diseases 2 1 focus
Diabetes: Glycation/A1C 2 1 focus
Drug Toxicity: Methotrexate 2 1 focus
Glucagon: Excess Secretion 2 1 focus
Gynecomastia 2 1 focus
HPA Axis Dysregulation 2 1 focus
Insulinitis 2 1 focus
Low Immune Function: Thymus Dysfunction 2 1 focus
Serotonin Disorders 2 1 focus
Thymus Atrophy 2 1 focus
Ataxia: Idiopathic 1 1 focus
Brain: Microglial Activation 1 1 focus
Breast Cancer 1 1 focus
Chorea 1 1 focus
Clotting 1 1 focus
Dementia 1 1 focus
Food Poisoning 1 1 focus
Guillain-Barre Syndrome 1 1 focus
Huntington Disease 1 1 focus
Hyperinsulinism 1 1 focus
Insulin Resistance 1 1 focus
Lane-Hamilton syndrome 1 1 focus
Lectin-Induced Toxicity 1 1 focus
Miscarriage 1 1 focus
Myelopathy 1 1 focus
Neurologic Disorders 1 1 focus
Neuropathy 1 1 focus
Osteoarthritis 1 1 focus
Oxidative Stress 1 1 focus
Quick Summary: 20 associated Adverse Pharmacological Actions
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of GreenMedInfo or its staff.

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Wheat Sensitivities

Have you seen this study out of Denmark?  I'm wondering if there is any study on einkorn wheat bread made with a natural starter.  Starters digest gluten and, combined with a day-long cool water rise, appear to nullify the anti-nutrients found in grains.  I'm curious not only about the food we eat, but how it's prepared and how it interacts with other foods ingested at the same time. 

Wheat Breads without Gluten

Hi, So eating wheat bread without gluten like Paleo Bread, would you agree that it would be okay?



Wheat good or bad?

Everyone is different, but as Certified Health Coach and also a person with Celiac Disease, I recommend that most everyone stay away from wheat, period.  I advocate to many clients to limit grains all together. But knowing that each of us is different, the best way to find out about whether wheat is bad for you is to eliminate it from your diet for 2-4 weeks, then eat it again. (if you want to)  Then, listen to your body and see what it tells you.  Also pay attention to the way your body feels while you are eliminating the wheat/barley and rye (oatmeal optional, can be cross contaminated).Good Luck and wishing you the best!


Good question

This pertains mainly to modern hybridized wheat. However, ancient forms still present quite a few biological incompatibilities. So, its better to leave gluten containing grains alone altogether. In fact, my personal preference is to reduce the consumption of all grains, in favor of high-nutrient, lower carbohydrate vegetables.

Wheat Beer vs WGA and other known issues

Are the wheat beers causing the same problem as wheat bread? If you know the URL to previous articles please advise.

Wheat Beer is like making an extract of wheat

Since I brew my own beer I can answer this.

So short answer is yes, it has the gluten. The longer answer, since it's an extract it concentrates all the other things in wheat that make it such a problem. Wheat is wheat, doesn't matter if it's a fermented liquid or a fermented loaf, the lack of carbs from the starch of the kernel doesn't make it less of an issue. The main actors in wheat that cause people problems are obviously gluten, then a component of gluten - gliadin and a lectin called wheat germ agglutinin.

I don't have problems with barley, so not all gluten is equal.


Wheat Beer

Great question. Wheat beer does have a score of psychoactive/pharmacologically active peptides, which is one reason why a beer buzz can be so complex, and grandiose. Take the wheat out of the beer, and what do you have? Some good gf beers exist, I'm sure, but not "dark ones." Someone out there correct me if I am wrong.

Good question about the WGA. Not sure. I'll try to find out more. Thanks for commenting!

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Sayer Ji
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Easy Turmeric recipes + The Dark Side of Wheat

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