Are Cancer Stem Cells the Key to Discovering a Cure?

Cancer Stem Cells

From the perspective of conventional cancer treatment a diagnosis of multi-drug resistant cancer is equivalent to a death sentence. By the time such a diagnosis occurs, the patient's body has been irreversibly damaged by chemotherapy and radiation, and an even more aggressive cancer has emerged to take the place of the original one.

Tragically, these treatments do not simply fail, but make the cancers more malignant.  This fact is effectively concealed by the name multidrug resistant cancer which makes it seem as if the cancer was so exceptionally resistant and malignant that the normally effective drugs used to treat it just couldn't do the job.  

But wouldn't it be more accurate to call this multi-drug failed cancer, putting the responsibility back on the medical establishment, as it should be, in recognition of the impotence, or worse, cancer-promoting nature of its treatment choices?

In other words, instead of blaming the treatment failure on the patient's body – or a set of virulent gene mutations within their cancer – it is time we look more closely at why conventional chemotherapy and radiation-based treatments breed multidrug resistance within the cancer of patients, who ultimately succumb to the effects of the treatment and not the cancer they were originally diagnosed with.

How Conventional Cancer Treatment Creates Greater Malignancy

Multidrug resistant cancer is the byproduct of cancer doctors (oncologists) throwing the chemical and radiological kitchen sink at the patient and not only failing to improve their condition, but significantly worsening it. How so? In order to understand how conventional treatment drives the cancer into greater malignancy, we must first understand what cancer is....

Tumors are actually highly organized assemblages of cells, which are surprisingly well-coordinated for cells that are supposed to be the result of strictly random mutation. They are capable of building their own blood supply (angiogenesis), are able to defend themselves by silencing cancer-suppression genes, secreting corrosive enzymes to move freely throughout the body, alter their metabolism to live in low oxygen and acidic environments, and know how to remove their own surface-receptor proteins to escape detection by white blood cells. In a previous article titled "Is Cancer An Ancient Survival Program Unmasked?" we delved deeper into this emerging view of cancer as an evolutionary throw-back and not a byproduct of strictly random mutation.

Because tumors are not simply the result of one or more mutated cells "going rogue" and producing exact clones of itself (multi-mutational and clonal hypotheses), but are a diverse group of cells having radically different phenotypal characteristics, chemotherapy and radiation will affect each cell type differently.

Tumors are composed of a wide range of cells, many of which are entirely benign.

The most deadly cell type within a tumor or blood cancer, known as cancer stem cells (CSCs), has the ability to give rise to all the cell types found within that cancer.

They are capable of dividing by mitosis to form either two stem cells (increasing the size of the stem population), or one daughter cell that goes on to differentiate into a variety of cell types, and one daughter cell that retains stem-cell properties.

This means CSCs are tumorigenic (tumor-forming) and should be the primary target of cancer treatment because they are capable of both initiating and sustaining cancer.  They are also increasingly recognized to be the cause of relapse and metastasis following conventional treatment.

CSCs are exceptionally resistant to conventional treatment for the following reasons

  1. CSCs account for less than 1 in 10,000 cells within a particular cancer, making them difficult to destroy without destroying the vast majority of other cells comprising the tumor.[1]
  1. CSCs are slow to replicate, making them less likely to be destroyed by chemotherapy and radiation treatments that target cells which are more rapidly dividing.
  1. Conventional chemotherapies target differentiated and differentiating cells, which form the bulk of the tumor, but these are unable to generate new cells like the CSCs which are undifferentiated.

The existence of CSCs explains why conventional cancer treatment has completely missed the boat when it comes to targeting the root cause of tumors. One reason for this is because existing cancer treatments have mostly been developed in animal models where the goal is to shrink a tumor. Because mice are most often used and their life spans do not exceed two years, tumor relapse is very difficult, if not impossible to study.

The first round of chemotherapy never kills the entire tumor, but only a percentage. This phenomenon is called the fractional kill. The goal is to use repeated treatment cycles (usually six) to regress the tumor population down to zero, without killing the patient.  

What normally occurs is that the treatment selectively kills the less harmful populations of cells (daughter cells), increasing the ratio of CSCs to benign and/or less malignant cells.  This is not unlike what happens when antibiotics are used to treat certain infections. The drug may wipe out 99.9% of the target bacteria, but .1% have or develop resistance to the agent, enabling the .1% to come back even stronger with time.

The antibiotic, also, kills the other beneficial bacteria that help the body fight infection naturally, in the same way that chemotherapy kills the patient's immune system (white blood cells and bone marrow), ultimately supporting the underlying conditions making disease recurrence more likely.

The reality is that the chemotherapy, even though it has reduced the tumor volume, by increasing the ratio of CSCs to benign daughter cells, has actually made the cancer more malignant.

Radiotherapy has also been shown to increase cancer stem cells in the prostate, ultimately resulting in cancer recurrence and worsened prognosis.[2]  Cancer stem cells may also explain why castration therapy often fails in prostate cancer treatment.[3]

 

Natural Cancer Fighters

Non-Toxic Natural Substances Which Target and Kill CSCs

Natural compounds have been shown to exhibit three properties which make them suitable alternatives to conventional chemotherapy and radiotherapy:

  1. High margin of safety: Relative to chemotherapy agents such as 5-fluorouracil natural compounds are two orders of magnitude safer
  2. Selective Cytotoxicity: The ability to target only those cells that are cancerous and not healthy cells
  3. CSCs Targeting: The ability to target the cancer stem cells within a tumor population.

The primary reason why these substances are not used in conventional treatment is because they are not patentable, nor profitable. Sadly, the criteria for drug selection are not safety, effectiveness, accessibility and affordability. If this were so, natural compounds would form an integral part of the standard of care in modern cancer treatment.

Research indicates that the following compounds (along with common dietary sources) have the ability to target CSCs:

  1. Curcumin (Turmeric)
  1. Resveratrol (Red Wine; Japanese Knotweed)
  1. Quercetin (Onion)
  1. Sulforaphane (Brocolli sprouts)
  1. Parthenolide (Butterbur)
  1. Andrographalide (Andrographis)
  1. Genistein (Cultured Soy; Coffee)
  1. Piperine (Black Pepper)

Additional research found on the GreenMedInfo.com Multidrug Resistance page indicate over 50 compounds inhibit multidrug resistance cancers in experimental models.


[1] Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med. 1997 Jul ;3(7):730-7. PMID: 9212098

[2] Long-term recovery of irradiated prostate cancer increases cancer stem cells. Prostate. 2012 Apr 18. Epub 2012 Apr 18. PMID: 22513891

[3] Stem-Like Cells with Luminal Progenitor Phenotype Survive Castration in Human Prostate Cancer. Stem Cells. 2012 Mar 21. Epub 2012 Mar 21. PMID: 22438320

Related Blogs

Is Cancer An Ancient Survival Program Unmasked?

Stress Hormones Found To Make Cancer Resistant To Treatment

Metalloestrogens is A New Class Of Cancer Causing Estrogens

Does Chemo & Radiation Actually Make Cancer More Malignant?

Research: Some Cancer Diagnoses Kill Quicker Than The Cancer

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of GreenMedInfo or its staff.

Comment viewing options

Select your preferred way to display the comments and click "Save settings" to activate your changes.

Did you guys read the article?



The article is written in part to bring into awareness that a major problem with "Curing" cancer is that cancers have a group of stem cells that have been resistant to conventional medicine. This article then goes on to explain there are numerous herbs that do in fact kill the originating stem cells within the cancer and can bring on a real and complete cure. This article is NOT about getting stem cell therapy.

Cure for Cancer



There are over 300 known natural cures for all cancers. In fact Dr Leonard Coldwell, has stated on many YouTube videos, that cnacer can be totally healed in 2 to 16 weeks, when you follow his protocol, as well as others. I was surprised to read the title to this article. "Are cancer stem cell the key to discovering a cure?" Please inform your readers that there has always been a cure. No one should have ever died from cancer, but because the FDA and Big Pharma, are more concerned about profits, they have been able to brainwash people into thinking that they are still searching for a cure. Many lives are being lost every year, because of the ongoing deception of the American people and to people around the world. You can start by listening to the Youtube video series of 6 videos titled "KILL CANCER" or any videos titled "Cures for Cancer" or "Forbidden Cures."  Please help to enlighten people, and not keep them in darkness. Thank you

Cancer and Stem Cells



Dear Sayer Ji,

There are few people in the alternative medicine scene as knowledgeable as you in the scientific background of disease. I am enjoying your articles. Stem cells will be important in future cancer cures.

For Carole Hilton, the patient above, I want to advise her to be very careful. Desperate as you are for a cure: Stem cells are not yet a viable option. Anybody who promises a stem cells cure right now is a scharlatan out for your money. Please, be careful! And I wish you the very best for your chemotherapy - your best bet at this moment!

Alexa Fleckenstein M.D., physician, author.

CANCER



Thank you so much- I want desperately to have stem cell treatment.  I went thru breast cancer last august with a lumpectomy, chemo & radiation.  Then in January they found small cell Ca in my lungs and adrenal gland.  I am at present going thru chemo again- my third sesson in progress. Don't know if I am going to have radiation or not this time.  I have my final session the end of May.  I have tried to find the closest place I can go for treatment for stem cell.  I heard there was some in Illinois--I am (LIVING thank God) in Iowa and only have Social Security. Please if you can help somehow to enroll in stem cell research please include me.

Carole Hilton  (not Conrad) so I threw him back LOL  319-270-3733 sidewaysally @gmail.comN

Cancer and Stem Cells



Dear Carol Hilton - please, see my remarks below!

Alexa Fleckenstein M.D.

Comment viewing options

Select your preferred way to display the comments and click "Save settings" to activate your changes.
Login or Register to write a comment

Popular Threads

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2017 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.