Sayer Ji
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Exercise Stops The Mitochondrial Aging Process In Its Tracks

Exercise Halts The Mitochondrial Aging Process In Its Tracks

New research published in the American Journal of Physiology indicates that exercise may minimize, and even reverse, age-associated declines in mitochondrial function.[1]  This has wide-ranging implications, as the health of the mitochondria intimately affect every cell, tissue and organ within the human body.

Mitochondria are known as the "powerhouse" of the cell because they are responsible for producing the body’s primary source of chemical energy: adenosine triphosphate (ATP), but they are also intimately involved in a wide range of other indispensable cellular functions, e.g. neurotransmitter, hormone and RNA/DNA production, which is all the more fascinating considering that they have their own bacteria-like DNA ring completely foreign to our own.  

As we age, mitochondrial density (the number of mitochondria per cell), and mitochondrial quality (its genetic and structural integrity) decline.  While this is a natural process, it can be greatly accelerated as a result of excessive stress, environmental radiation and chemical exposures (including pharmaceutical drugs), nutritional deficiencies, imbalances and/or incompatibilities, and mitochondrial DNA defects inherited maternally.

In the new study titled, "Age-associated Declines in Mitochondrial Biogenesis and Protein Quality Control Factors are Minimized by Exercise Training," researchers found animals that underwent exercise training, consisting of treadmill running at 60% of the initial VO2max (also known as maximal aerobic capacity, which is the maximum capacity of an individual's body to transport and use oxygen during incremental exercise), "…reversed or attenuated significant age-associated (detrimental) declines in mitochondrial mass," as well as a wide range of additional age-associated mitochondrial changes, e.g. SIRT1 activity, AMPK, COX 4, etc.

The researchers summarized their conclusions:

"Exercise training also decreased the gap between young and old animals in other measured parameters including NRF1, TFAM, Fis1, Mfn1 and polynucleotide phosphorylase (PNPase) levels. We conclude that exercise training can help minimize detrimental skeletal muscle aging deficits by improving mitochondrial protein quality control and biogenesis."

 

Mitochondria

Mitochondrial biogenesis is the process by which new mitochondria are formed in the cell, and it is generally believed that the higher the mitochondrial copy number (or mitochondrial mass) the more protective it is for the cell.  Most of the research in the past 40 years has been performed on muscle mitochondria, which are believed to confer greater resistance to fatigue and strength. The muscle cell type with the highest mitochondrial density is cardiac muscle – because the heart never stops working – which may have as high as 10-100 times more mitochondria per cell versus skeletal muscle (approximately 50 vs. 5,000). This is also why statin drugs like Lipitor (atorvastin), which reduce heart mitochondrial function,[2] are so illogical for the primary prevention of heart disease; a disease which is certainly not caused by a lack of drugs. The well-known myotoxicity (muscle-damaging) properties of this chemical class of drugs may be primarily caused by their fatal disruption of mitochondrial function, and may explain why statins have been linked to such a broad range of pathologies, numbering over 300 on our database alone.

This is not, in fact, the first study showing exercise-induced mitochondrial biogenesis. A 2011 study published in the Journal of Applied Physiology showed that exercise training increased mitochondrial biogenesis in the brains of mice, which opened the door to the possibility that exercise may reduce or reverse age-associated declines in cognitive function, especially those related to inactivity.[3]

Another more recent study published in the journal Neuroscience (Jan. 2012) titled, "Exercise induces mitochondrial biogenesis after brain ischemia in rats," found that "…exercise can promote mitochondrial biogenesis after ischemic injury [associated with stroke], which may serve as a novel component of exercise-induced repair mechanisms of the brain."[4]

Finally, a 2011 study published in the journal Applied Physiology, Nutrition and Metabolism, reviewed the role of exercise training in inducing mitochondrial biogenesis in tissues beyond that of skeletal muscle, namely, adipose tissue, liver, brain and kidney.[5]

Exercise, of course, is another way of saying intentionally moving our bodies – something which increasingly, in a world of mechanization and technological extension and/or substitution of bodily functions (transhumanism?), is performed regularly only rarely by the majority of the world’s industrialized populations.

The saying "move it or lose" speaks volumes to what is implied by the research on mitochondrial biogenesis, or conversely, the mitochondrial degeneration implied by lack of exercise.  In other words, exercise may not be so much a 'magic bullet' that we apply to disease like we would a palliative drug. Although we have indexed over 80 "diseases" which appear to be prevented or improved with exercise, another way of putting it is: 80+ "diseases" may be caused by exercise deficiency, i.e. daily, moderate-to-intense physical exertion, may be a default, necessary state of the body in order to produce or maintain health. This is, after all, the very meaning of re-generation, which is the truly the default moment-to-moment state of our body, and the implied meaning of "re-creational" activities. 

In closing, there are a few natural substances which may enhance mitochondrial biogenesis, but please remember there is no "magic bullet" superior to a truly healthy diet, lifestyle and attitude:

  • Grape polyphenols: Shown to increase muscle mitochondrial biogenesis and decrease age-associated muscle atrophy in aged rats.[6]
  • Acai berry: While I am truly fatigued by the acai-berry hype that has proliferated like a virus with the typical multi-level-marketing intensity over the past few years, it has been studied in the fruit fly model to promote healthy aging and reducing oxidative stress, while measurably increasing transcript levels of genes involved in mitochondrial biogenesis.[7]
  • Resveratrol: It has been shown to induce mitochondrial biogenesis in a rat model.[8]
  • Quercetin: Shown to increase brain and muscle mitochondrial biogenesis and exercise tolerance in an animal model.[9]



[1] Age-associated Declines in Mitochondrial Biogenesis and Protein Quality Control Factors are Minimized by Exercise Training. Am J Physiol Regul Integr Comp Physiol. 2012 May 9. Epub 2012 May 9. PMID: 22573103

[2] Effects of atorvastatin on heart mitochondrial function and coenzyme Q content in the experiment. Bratisl Lek Listy. 2011 ;112(11):603-4. PMID: 22180983

[3] Exercise Training Increases Mitochondrial Biogenesis in the Brain. J Appl Physiol. 2011 Aug 4. Epub 2011 Aug 4. PMID: 21817111

[4] Exercise induces mitochondrial biogenesis after brain ischemia in rats. Neuroscience. 2012 Jan 8. Epub 2012 Jan 8. PMID: 22266265

[5] Skeletal muscle and beyond: the role of exercise as a mediator of systemic mitochondrial biogenesis. Appl Physiol Nutr Metab. 2011 Sep 2. Epub 2011 Sep 2. PMID: 21888528

[6] Polyphenols decreased liver NADPH oxidase activity, increased muscle mitochondrial biogenesis and decreased gastrocnemius age-dependent autophagy in aged rats. Free Radic Res. 2012 May 18. Epub 2012 May 18. PMID: 22607117

[7] A botanical containing freeze dried açai pulp promotes healthy aging and reduces oxidative damage in sod1 knockdown flies. Age (Dordr). 2012 May 26. Epub 2012 May 26. PMID: 22639178

[8]  Resveratrol induces mitochondrial biogenesis and ameliorates Ang II-induced cardiac remodeling in transgenic Blood Press. 2010 Jun;19(3):196-205. PMID: 20429690 rats harboring human renin and angiotensinogen genes.  

[9] Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance. Am J Physiol Regul Integr Comp Physiol. 2009 Apr;296(4):R1071-7. Epub 2009 Feb 11. PMID: 19211721

Related Blog

6 Bodily Tissues That Can Be Regenerated Through Nutrition

Written by Sayer Ji, founder

 

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of GreenMedInfo or its staff.

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Mitochondria



Cell and mitochondrial membranes mis-constructed of unbalanced, oxidized, damaged fats cripple these energy producing organelles and mean poor oxygen penetration. Exercise moves oxygen, and ends fluid stagnation as it squeezes out wastes... A healthy body charge assists oxygen delivery and results from a number of factors starting w proper breathing, high antioxidant intake and a happy mind. Eliminating toxic charge thieves like metals, bad fats, acidic pH/emotions and pathogens help on the other end.

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Sayer Ji
Founder of GreenMedInfo.com

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