Sayer Ji
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This Humble Food Extract Puts Bone Drugs To Shame

This Humble Food Extract Puts Bone Drugs To Shame

An ancient fermented food puts pharmaceutical drugs for bone loss to shame...

According to research published in the British Journal of Pharmacology in 2008, alendronate (Fosamax), raloxifene (Evista) and estradiol (estrogen, E2) are inferior to the phytoestrogen genistein commonly found in fermented soy*, red clover, kudzu, fava beans and coffee, in preserving bone mineral density (quantity) and strength (quality) in an animal model of menopausal osteoporosis.

Genistein has been extensively researched for its potential therapeutic role in osteoporosis prevention and treatment,  as well as a mind-boggling 170+ additional health conditions. It is likely the main reason why soy, and particularly fermented soy, has been regarded as both a food and a medicine in Asian culture.

What makes this finding so groundbreaking is that genistein is a food derivative, whereas the three categories of drugs compared to it in the study are evolutionarily and biologically alien chemicals (xenobiotics) with profound, unintended adverse health effects. For example, the class of drugs known as bisphosphonates which include Fosamax have been linked to over 40 adverse health effects.

In essence, this study calls into question the multi-billion dollar "osteoporosis" and "osteopenia" industry's most lucrative commodities. Foods and food extracts, of course, do not lend themselves to being patented, which is why this study will likely never receive the multi-million dollar funding required to bring it to the level of a human clinical trial.  Moreover, natural bone loss associated with aging has been over-medicalized. We explored this problem in the following article: "Osteoporosis Myth: The Dangers of High Bone Mineral Density."

*non-fermented soy contains genistin, whereas friendly bacteria in our gut or in cultured foods such as miso biotransform it into genistein. 


The true value of this study becomes apparent when we look at the drugs in greater detail. Alendronate (Fosamax), for instance, was originally used to soften water in irrigation systems used in orange groves. It has the ability to ulcerate and puncture the stomach, which is why it is suggested it be taken with water and the person stands or sits up for half an hour. It has been linked to at least 19 serious adverse health effects, including bone fracture itself!

Fosomax Disease List

View All 24 Articles Here

Raloxifene (Evista), on the other hand, has been proven to increase the risk of pulmonary embolism, venous thrombosis, sroke and coronary artery disease to name but only a few areas of grave concern. 

Evista Disease List

View all of our articles on raloxifene

Estradiol, though produced naturally in our body, may have cardiotoxic and carcinogenic properties when levels are too high, as may occur during pharmaceutically-based hormone replacement therapy, or when detoxification/transformative pathways are working sub-optimally.

Genistein has much weaker estrogenic activity in comparison to estradiol, and yet it is capable of binding to the same estrogen receptors for a much longer duration, which may result in significant positive effects when endogenously produced estrogen levels fail to meet the body's optimal requirements. Genistein is also highly selective, capable of binding and stimulating bone estrogen receptor sites (resulting in increased strength/density), whereas down-regulating breast density by taking up, and weakly stimulating estrogen receptor sites within breast tissue.

This enables the plant estrogen - paradoxically - to block out and/or reduce the proliferative activity of excess estradiol and related xenobiotic estrogen exposures. The same principle, also known as Selective Estrogen Receptor Modulation (SERM), has also been observed operative within the phytoestrogens found in flaxseed.


For Additional Reading

Relevant Video: The Shocking Truth About Bone Scans & Breast Cancer

Relevant Research Sections on GMI: GenisteinOsteoporosisBone Fractures

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of GreenMedInfo or its staff.

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Confusion



On this page and another (http://www.greenmedinfo.com/blog/green-tea-and-tai-chai-team-protect-bones?utm_source=www.GreenMedInfo.com&utm_campaign=d17bad5a06-Greenmedinfo&utm_medium=email&utm_term=0_193c8492fb-d17bad5a06-86833985) we are being told that phytoestrogens are key to preventing osteoporosis - better than drugs or milk.

But then on this page, there is also a link to this article: Confirmed: The Lower Your Bone Density, The Lower Your Breast Cancer Risk.

 

So do we consume phytoestrogens to help us prevent osteoporosis or do we avoid them to prevent breast cancer?

 

Confusion



Thank you for bringing this question to our attention. As far as the role of phytoestrogens in bone health and the bone density question, there are a number of considerations here. The study on genistein did not show increased bone density, rather, it maintained normal density follow ovariectomy, and increased bone quality (strength). This is a perfect example of a modulator of hormone health, capable of down-regulating estrogen activity in the case of estrogen dominance (or excessive xenobiotic exposure to estrogen-mimicking petrochemicals), while stimulating the receptors in the case of deficiency. And so, there is really no contradiction here as far as I can see. Thanks for commenting! 

Hormone Replacement



The people of Japan eat a lot of soy, fermented soy, natto, etc.  Supposedly very good for women, and bones, etc.  I lived in Japan for three full years, and I never saw so many hunched-over women as I saw when we lived there.  There is more to women's health than soy-based nutrition.  The only soy I take is a supplement, Nattokinase (natto based), to keep my arteries clear.  Other than that, I steer clear of soy.

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Sayer Ji
Founder of GreenMedInfo.com

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