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A study published in the European Review for Medical and Pharmacological Sciences has revealed something quite counterintuitive about chocolate, one of the world's most prized 'high-fat' foods. This strangely medicinal 'sweat treat,' which ironically you find in the candy aisle at the pharmacy, improved markers of cardiovascular disease, including the reduction of belly fat, and only after one week of consumption.
Researchers from the Department of Neuroscience, Division of Human Nutrition, University of Tor Vergata, Rome, in a paper titled 'Effects of dark chocolate in a population of Normal Weight Obese women: a pilot study,' describe the effects of 100 gram of dark chocolate taken for one week (approximately a 3 ounce bar) in so-called 'normal weight obese (NWO)' syndrome subjects.
NWO syndrome is defined as 'an excessive body fat associated with a normal body mass index and characterized by a higher risk for cardiovascular morbidity and mortality,' and has been found to be associated with a 2.2 fold increased risk of cardiovascular mortality in women compared with those with low body fat. Generally, those with NWO have 30% or more total body fat mass percentage and significantly higher values of proinflammatory cytokines such as IL-1, IL-6, IL-8 and TNF-α.  
The study looked at the effects of dark chocolate consumption on the following:
- Blood lipid profiles
- Biochemical parameters (e.g. interleukins)
- Blood pressure
- Abdominal circumference (i.e. 'belly fat')
A modest sample size of 15 women with NWO syndrome, aged 20-40 years, were included in the study. They received 100 grams of dark chocolate (DC) containing 70% cocoa for 7-days. Dual energy-X-ray absorptiometry (DXA) was used to measure body composition. Blood pressure, anthropometric measurements, biochemical parameters and plasma levels of some cytokines were measured before and after DC consumption.
The results were described as follows:
After DC [dark chocolate] consumption, we observed a significant increase in the HDL cholesterol level (Delta% = +10.41±13,53; p ≤ 0.05), a significant decrease of total cholesterol/HDL cholesterol ratio (Delta %= -11.45±7.03; p ≤ 0.05), LDL/HDL cholesterol ratio (Delta % = -11.70±8.91; p ≤ 0.05), and interleukin-1 receptor antagonist (IL-1Ra) (Delta % = -32.99±3.84; p ≤ 0.05). In addition, a reduction in abdomen circumference was observed. We also found a positive correlation between changes in atherogenic indices, and IL-1Ra, abdomen reduction.
The authors concluded:
Our findings suggest that regular consumption of DC could be useful in maintaining a good atherogenic profile, due to the favorable effects on HDL cholesterol, lipoprotein ratios and inflammation markers.
This study should debunk several myths regarding chocolate consumption, such as 'it makes you fat,' 'it clogs your arteries,' or 'it is bad for blood sugar.' While low-cocoa chocolate, which is often high in sugar and may contain cow's milk products, preservatives and lower quality fats, may not translate into the benefits observed in this study, a high-quality, high-cocoa chocolate may go quite a long way in enhancing general health and well-being. This is especially so if one chooses organically-produced, fair-trade and preferably raw chocolate. The raw part is especially important as the potent antioxidant compounds in cocoa are found at much higher and physiologically relevant concentrations in the non-heated and unprocessed forms. Indeed, according to the authors of this study, "[the] health properties of cocoa consumption were mainly related [in previous research] to the antioxidant properties of polyphenolic compounds, among others monomeric flavanols, epicatechin, catechin and oligomeric, procyanidins."
The specific sample of dark chocolate used in this study was assayed to contain the following compounds:
It is believed that one of the primary lipid-modulating, and HDL-raising compounds in high-quality chocolate is the saturated stearic acid found in the cocoa butter. This is also a counterintuitive finding since many decades of propaganda has convinced the mainstream that 'saturated' fats are bad and 'unsaturated' fats are good. As the researchers state:
Because of its high saturated fat content, chocolate is often postulated to have a hypercholesterolemic effect. However, the high content of stearic acid (~30% of fatty acids) is considered to be neutral with respect to total and LDL cholesterol, and positive on serum concentration of HDL."
It is truly remarkable that the dark chocolate was capable of raising the so-called 'good' HDL cholesterol 10% within only 7 days. This is a feat pharmaceutical lipid-modulating drugs can not accomplish, unless we are talking about patented forms of niacin (Niaspan) or fish oil (Lovaza), which really don't count since they are really just glorified dietary supplements.
Previously, we looked at how chocolate – believe it or not – could replace the need for the $29 billion dollar plus cholesterol-lowering statin drug industry, by addressing and remedying the underlying pathology of the blood vessels (endothelial dysfunction) that leads to atherosclerosis and eventual cardiac morbidity and mortality. We feel the research, if you would like to peruse it, is remarkably compelling: Chocolate Gives Statins A $29 Billion Run For Their Money
When it is all said and done, chocolate should not be viewed simply as a natural "medicine,' to suppress bodily symptoms or clinical parameters, as anyone who 'loves' the way it makes them feel can plainly tell. As my friend Marc David pointed out in his recent article on Vitamin P[leasure], the experience of joy within the enjoyment of chocolate is itself a highly medicinal 'nutritional fact' that will never make it onto the label of a product, nor will be easily (if ever) comprehended through clinical trials. Let the research support what most of us already know: food can be medicine, yes, but the point is to use it in moderate, culinary doses so that mega-dose, heroic 'medicine' will never become necessary. [this is one of the basic principles of my project with Tania Melkonian called EATomology]
For additional research on the health benefits of chocolate and/or cocoa please visit our research page dedicated to the topic: http://www.greenmedinfo.com/substance/chocolate
 ROMERO-CORRAL A, SOMERS VK, SIERRA-JOHNSON J, KORENFELDY, BOARIN S, KORINEK J, JENSEN MD, PARATI G, LOPEZJIMENEZ F. Normal weight obesity: a risk factor for cardiometabolic dysregulation and cardiovascular mortality. Eur Heart J 2010; 31: 737-746.
 DI RENZO L, GLORIA-BOTTINI F, SACCUCCI P, BIGIONI M, ABENAVOLI L, GASBARRINI G, DE LORENZO A. Role of interleukin-15 receptor alpha polymorphisms in normal weight obese syndrome. Int J Immunopathol Pharmacol 2009; 22: 105-113.
 DI RENZO L, GALVANO F, ORLANDI C, BIANCHI A, DI GIACOMO C, LA FAUCI L, ACQUAVIVA R, DE LORENZO A. Oxidative stress in normal-weight obese syndrome. Obesity (Silver Spring) 2010; 18: 2125-2130.
 MEHRINFAR R, FRISHMAN WH. Flavanol-rich cocoa: a cardioprotective nutraceutical. Cardiol Rev 2008;