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Red Ginseng Improves Vasodilation and Glucose Control

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Red Ginseng Improves Vasodilation and Glucose Control

New scientific evidence illustrates why Korean Red Ginseng (panax ginseng) has been used for centuries to improve health and longevity.

Red ginseng and blood vessel wall health

A clinical study from St. Michael's Hospital and the University of Toronto has found that red ginseng boosts blood vessel vasodilation.

The researchers gave three grams of powdered red ginseng to 16 healthy adults on four different occasions. They were tested for blood pressure and blood vessel vasodilation – which is the ability of the blood vessels to expand and contract. Another way of stating this is flexibility. Better vasodilation relates to better blood vessel wall flexibility.

In this placebo-controlled, double-blind study with crossover design, the researchers tested the subjects for vasodilation at the brachial artery 90 minutes and 180 minutes after receiving the red ginseng.

The study found that the red ginseng significantly changed the flow-mediated vasodilatation compared to the placebo.

The researchers then tested two fractions of the constituents to see what were the active constituents. They found that a ginsenosides extract produced a similar vasodilation effect, but not a polysaccharide extract.

The researchers concluded:

"Korean red ginseng acutely improved endothelial function in healthy individuals, which appears to be attributable to its ginsenoside containing fraction. Our data confirm preclinical data and support the potential for these compounds as targets for therapeutic strategies in disorders involving endothelial dysfunction."

Korean red ginseng improves glucose control

Another clinical study, from the Republic of Korea's Yonsei University, found that red ginseng significantly improves glucose control among newly diagnosed type 2 diabetes patients.

The researchers studied 41 recently diagnosed diabetes patients. Half (21) were given a placebo and half were given five grams of Korean red ginseng in tablet form for twelve weeks.

The researchers tested their blood levels of insulin, glucose and C-peptides using two-hour glucose tolerance testing.

The patients given the Korean red ginseng showed a significant decrease in glucose levels at 30 minutes – by 22.24 mg/dL (serum) and 17.5 mg/dL (whole blood). The red ginseng group also had lower glucose levels at zero minutes and lower glucose area-under-the-curve levels.

The placebo group showed little or no change in glucose parameters.

The red ginseng group also showed lower C-peptide concentrations compared with the placebo group. 

What are C-peptides?

C-peptides provide linkages for insulin chains, as well as help insulin bind to cell receptors.

Lower C-peptide levels in a type 2 diabetes patient are a good thing because higher levels indicate greater insulin resistance. In type 2 diabetes the person is still producing insulin but the cells have become more resistant to it so there will be more C-peptides in the blood along with insulin.

Lower C-peptide levels in type 1 diabetes are not good, because this indicates that the pancreas is not producing much insulin. C-peptide is a better measurement of insulin production in a type 1 diabetes patient because of injected insulin.

Korean red ginseng is Panex ginseng that has been steamed at 212 F (98-100 C) for 2-3 hours. This processing makes available higher levels of phytocompounds, which have been found to be anti-cancer and anti-aging among others.


Jovanovski E, Peeva V, Sievenpiper JL, Jenkins AL, Desouza L, Rahelic D, Sung MK, Vuksan V. Modulation of endothelial function by korean red ginseng (Panax ginseng c.a. Meyer) and its components in healthy individuals: a randomized controlled trial. Cardiovasc Ther. 2014 Apr 23. doi: 10.1111/1755-5922.12077.

Bang H, Kwak JH, Ahn HY, Shin DY, Lee JH. Korean red ginseng improves glucose control in subjects with impaired fasting glucose, impaired glucose tolerance, or newly diagnosed type 2 diabetes mellitus. J Med Food. 2014 Jan;17(1):128-34. doi: 10.1089/jmf.2013.2889.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of GreenMedInfo or its staff.

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