Research: Curcumin Is A Triple Negative Breast Cancer Killer

Research: Curcumin Is A Triple Negative Breast Cancer Killer

A new study from Zheijian Provincial People's Hospital in Zheijiang, China indicates that a compound in turmeric known as curcumin, which gives the spice its characteristic saffron-like color, is capable of inducing programmed cell death (apoptosis) within triple negative breast cancer cells.1

Triple negative breast cancer (TNBC), so named because the cells do not have the characteristic receptors for estrogen, progesterone and Her2/neu, is considered the most treatment resistant, primarily because these 'missing receptors' are required for many of the most popular conventional treatments to work, e.g. Tamoxifen targets estrogen receptors. For this reason, TNBC is considered the most aggressive, the most likely to be treated with less-targeted (and therefore more toxic) forms of chemotherapy, and the soonest to return when treatment fails.

Approximately 15-25% of all breast cancer cases are triple negative. Unfortunately, however, the most visible non-profit foundation dedicated to bringing awareness to the condition, the Triple Negative Breast Cancer Foundation, is focused almost exclusively on raising awareness and money for a future pharmaceutical "cure"  – much in the same way as its partner, Susan G. Komen, and the larger breast cancer awareness organization, Breast Cancer Awareness Month, act as if removing and addressing the obvious causes of cancer, e.g. carcinogenic chemical and radiation exposures, were not the first priority.  For those suffering through or recovering from treatment right now, or trying to decide what to do with a new diagnosis, this latest Chinese study is promising.

Detractors, of course, point out that this latest curcumin research occurred on the level of a cell study, which in the pyramidal power structure of "evidence-based medicine," where the randomized, double-blind and placebo-controlled human clinical study is the sole determinant of the ultimate truth, is the most insignificant, and least compelling as far informing treatment decisions. This view, however, is rather naive, insofar the criteria for determining a substance's potential for future use as an FDA drug is not its effectiveness, safety or availability to those in need, rather, how proprietary and profitable the formula is to manufacture, distribute and market to consumers. The "gold standard" of evidence-based medicine therefore becomes literally: "those who own the gold make the standard."

This is not the first study to reveal curcumin's potential value in treating breast cancer. A growing body of experimental evidence  clearly shows that curcumin provides a potential drug alternative. has indexed over 60 in vitro and animal studies demonstrating either curcumin's direct anti-breast cancer activity, or, its ability to enhance breast cancer's sensitivity to conventional chemotherapy.  Also, the open access project has indexed over 1500 abstracts from the National Library of Medicine on its potential value in over 500 health conditions: Turmeric Breast Cancer.

Other pre-clinically confirmed natural candidates for combating triple negative breast cancer include:

For a far wider dataset on potential natural breast cancer solutions, and common avoidable causes, visit the Breast Cancer Research health guide: Natural Breast Cancer Research


Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of GreenMedInfo or its staff.

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Are Turmeric and Curcuma exactly the same? I live in Thailand and can only buy curcuma,looks and tastes the same as turmeric, but I could not find a confirmation that the two names are synonyms. Thanks for any info.

pseudo science

SkinnyLiver--I think you need to check your history on polio. Salk vaccine did not cure or curb polio. First, if you accept the CDC standard of an epidemic being a disease affecting at least 10% of the population, polio fails this standard as it never hit more than 5% of the population. Second, polio was on the wane before the vaccine was released. It did nothing to end the condtion in the US. Further, every case of polio diagnosed since then was due to the vaccine itself. And lastly, polio is a symptom syndrome which still exists. It tends to show up periodically in a culture and then leaves. It is not a contagious disease and is more in line with the increase of certain toxic environmental effects than a virus. The rise of the use of DDT is more coordinated with polio than it is to a virus. So, Salk and Sabin not patenting their work, is a strange gift since this vaccine has been used to poison millions of people/kids worldwide. Given the use of medicine as an entre to various cultures, and given the development and use of biological warfare by this country, I have to apply my skepticism to this so-called 'gift of science.' I think it falls right into the general category of pseudo-science that you correctly criticize.

Pseudo Science

Thanks Sayer for sharing your knowledge with us. Your honesty and action on this subject is a brave, bold move at a time when pseudo-science has claimed center stage. Unfortunately, we live in a time where a generally accepted form of pseudo-science exists. I must say that many rather regular working people so to speak, have felt for a long time that something was terribly wrong in Denmark. Medicine, pharmaceuticals, and climatology have all been sucking the life out of society while telling their fascinating stories of how they’re saving lives or the world in the process. I hope you believe me when I say that I would help someone in need if I could. With that said, I believe these fundraising schemes such as “Stand Up for Cancer” and “Breast Cancer” campaigns are only in existence for the personal gains of the ones responsible for their raise. When I think back over the years of fundraising events I can’t help but think of Jerry Lewis and his long effort (nearly 50 years) for Muscle Dystrophy Research with his annual telethons for what Jerry hoped would lead to the eventual “cure” for MS. This story of failure costing billions of dollars and producing no significant benefits should serve as a reminder that medicine and its researchers’ have little, if any interest in curing the disease when profits rely on the maintenance of the disease. That is just one example of many failed efforts since the last real cure that I can remember, the cure was for Polio. Strange too how I can remember Jonas Edward Salk’s words after the Polio vaccine was declared a success. Dr. Salk asked, who owned the patent, he replied, “There is no patent, could you patent the sun?” and therein lies the rub. The vaccine was rapidly developed and safely administered with NO PERSON PROFIT. And that’s where the real science appears to me to have ended.

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A microarray study on either invivo & or invitro may throw more clarity on the gene level efficacy.

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