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Roundup Herbicide Linked To Parkinson's-Related Brain Damage

Roundup Herbicide Linked To Parkinson's-Related Brain Damage

Alarming new research published in the journal Neurotoxicology and Teratology supports the emerging connection between glyphosate, the active ingredient in Roundup herbicide, and neurodegenerative conditions such as Parkinson's disease and Parkinsonian disorders.

Published this month (April, 2012), the new study entitled "Glyphosate induced cell death through apoptotic and authophagic mechanisms," investigated the potential brain-damaging effects of herbicides, which the authors stated "have been recognized as the main environmental factor associated with neurodegenerative disorders, such as Parkinson's disease."1

They found that glyphosate inhibited the viability of differentiated test cells (PC12, adrenal medula derived), in both dose-and-time dependent manners. The researchers also found that "glyphosate induced cell death via authophagy pathways in addition to activating apoptotic pathways."

Roundup herbicide is now a ubiquitous contaminant in our air, rain, groundwater, and food, making complete avoidance near impossible. A growing body of experimental evidence now indicates that it in addition to its neurotoxicity it also has the following.

Modes of Toxicity

  • Carcinogen
  • Endocrine Disruptor
  • Genotoxic
  • Biocide
  • Cytotoxic
  • Bioaccumulator
  • Hepatotoxic
  • Teratrogenic
  • Clastogenic
  • Oxidant
  • Aquacidal
  • Mutagenic
  • Aromatase Disruptor
  • Glutathione Down-regulator
  • Malondialdehyde Up-regulator
  • Necrotic
  • Nephrotoxic

Once marketed as "safe as table salt" by Monsanto, the original patent holder and manufacturer of this glyphosate-based herbicide, evidence now indicates it is toxic to human DNA at concentrations diluted 450-fold lower than used in agricultural applications.

This study only adds to human case reports of glyphosate-poisoning  and/or occupational exposure where neurological damage was a direct consequence.  A 2011 case study published in the journal Parkinsonism Related Disorders, entitled "Parkinsonism after chronic occupational exposure to glyphosate," reported the following incident:

Here we report a patient with parkinsonism following chronic occupational exposure to glyphosate. A previously healthy 44- year-old woman presented with rigidity, slowness and resting tremor in all four limbs with no impairment of short-term memory, after sustaining long term chemical exposure to glyphosate for 3 years as a worker in a chemical factory. The chemical plant produced a range of herbicides including: glyphosate, gibberellins, and dimethyl hydrogen phosphite; however, the patient worked exclusively in the glyphosate production division. She only wore basic protection such as gloves or a face mask for 50 h each week in the plant where glyphosate vapor was generated. She frequently felt weak. Two months before she came to our clinic, she had expe- rienced severe dizziness and blurred vision.

Another case study published in 2003 reported a case of parkinsonism subsequent to glyphosate exposure.

These case studies are also backed up by animal research. In the roundworm model of glyphosate exposure the chemical results in neurodegeneration directly associated with damage to the dopamine and GABA producing neurons. In the rat model, glyphosate exposure results in oxidative brain damage, particularly the substantia nigra, where the highest concentration of dopamine-producing cells reside, and which is the primary locus of neurological damage in Parkinson's disease.


1 Neurotoxicol Teratol. 2012 Apr 4. Epub 2012 Apr 4. PMID: 22504123

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Dow's Deadly Harvest: The Return of Agent Orange

Un-Earthed: Is Monsanto's Glyphosate Destroying The Soil?


Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of GreenMedInfo or its staff.

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Citation Added In 2 Spots

Sorry for the confusion. It was hyperlinked in one of the keywords, but is now added as an academic reference, as well. Thanks for noticing that!  Here it is again:

Round-up Intolerance

After being exposed to pesticides that caused a general intolerance to all pesticides, I can say I hate the spring and summer because of all the Round-up and other pesticides in the ambient air. My reaction is an inflammatory response in my lungs, bronchial lining, and my gastrointestinal system. There are many of us in the world who have a low tolerance for these synthetic poisons. They are obstacles to our freedom of movement without becoming ill from them.

Neurological Damage done by synthetic poisons.

In 1995, a fertilizer plant blew up in Fort Pierce, Florida, which is about 20 miles from where I live.  I was headed in the direction of Fort Pierce to eat at a restaurant about half-way between home and there, and I saw this huge plume of smoke in the air, and I said to my husband, "what in the world is that?" and he did not know.  When we stepped out of the car with our 2 year old daughter, Amanda, we smelled the stench of the explosion.  Within one day after being exposed to this "smoke" I began having neurological difficulties in the form of my legs and feet going numb, with anxiety attacks as a result.  My daughter even mused "remember, Mommy, my feet always hurting? well, now, it's okay, because I can't feel my feet".  I was taken by ambulance that same day, with the ambulance drivers ignoring my daughter's symptoms, and was declared to have idiopathic neuropathy.  I had told them that we'd all been exposed to the explosion of the Con-Agra plant but they snuffed that, said no, there's no way that would cause this.  To this day, 17 years later I'm still on medications for the neuropathy.

The air we are breathing

I know that we are being poisoned by Monsanto! Every time that I drive anywhere near where a farmer is out in the field working the earth - even if he is only disking (loosening up the earth) I have to roll all windows up in my car because of the pesticide smell being released into the air. I cannot breathe, my eyes get watery, I get all congested, I start coughing, the inside of my nose feels like it is swelling up (narrowing/closing), my voice even changes like I am getting sick (gets deeper sounding). All of this - just by driving a short distance by a farm without chemicals being applied to it at that time! It is all of the chemicals that were applied in the previous years that are being stirred up when the farmer disks. That poison does NOT go away!! Each and everytime the earth is disturbed after the Poison has been applied -the poison is released back into the air again!!!

You really should provide a link to the study.

Research of such import should be linked.

journal article

Can you please provide the citation and link to the article? Thank you!

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