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In order to assess the neurotoxic effects of fluoride and prove curcumin's protective role against it, researchers randomly divided up mice into four groups, for 30 days:
- Control (no fluoride)
- Fluoride (120 ppm): fluoride was given in distilled water drinking water without restriction.
- Fluoride (120 ppm/30 mg/kg body weight) + Curcumin: Oral dose of curcumin dissolved in olive oil along with fluoride in drinking water
- Curcumin: (30 mg/kg body weight)
In order to ascertain the effect of treatment, the researchers measured the malondialdehyde (MDA) content in the brains of the different treated mice. MDA is a well-known marker of oxidative stress/damage.
As was expected, the fluoride (F) only treatment group showed significantly elevated MDA levels vs. the non-fluoride treated control. The F + Curcumin group saw reduced MDA levels vs. the fluoride only group, demonstrating curcumin's neuroprotective activity against fluoride associated neurotoxicity.
The study concluded,
"Our study thus demonstrate that daily single dose of 120 ppm F result in highly significant increases in the LPO [lipid peroxidation, i.e. brain rancidity] as well as neurodegenerative changes in neuron cell bodies of selected hippocampal regions. Supplementation with curcumin significantly reduce the toxic effect of F to near normal level by augmenting the antioxidant defense through its scavenging property and provide an evidence of having therapeutic role against oxidative stress mediated neurodegeneration."
This is far from the first study to demonstrate curcumin's remarkable brain-saving properties. From the perspective of the primary research alone, there are over two hundred peer-reviewed published studies indicating that curcumin is a neuroprotective agent. On our own turmeric database we have 115 articles proving this statement: Turmeric Protects The Brain. We have also featured studies on turmeric's ability to protect and restore the brain:
- How Turmeric Can Save the Aging Brain From Dementia and Premature Death
- Turmeric Produces 'Remarkable' Recovery in Alzheimer's Patients
Considering the many chemical insults we face on a daily basis in the post-industrial world, turmeric may very well be the world's most important herb, with over 600 evidence-based health applications.
For more information, please review the following content:
- The Turmeric Drink that Can Revolutionize Your Health
- Research: Curcumin Is A Triple Negative Breast Killer
- Science Confirms Turmeric As Effective As 14 Drugs
[i] Bhatnagar M, Rao P, Saxena A, Bhatnagar R, Meena P, Barbar S. Biochemical changes in brain and other tissues of young adult female mice from fluoride in their drinking water. Fluoride. 2006;39:280–4. [Ref list]
[ii] Bhatnagar M, Sukhwal P, Suhalka P, Jain A, Joshi C, Sharma D. Effects of fluoride in drinking water on NADPH-diaphorase neurons in the forebrain of mice: A possible mechanism of fluoride neurotoxicity. Fluoride. 2011;44:195–9. [Ref list]