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A new review published in Autoimmunity Reviews titled, "On the relationship between human papilloma virus vaccine and autoimmune disease," is destined to reopen the controversy surrounding numerous reports of HPV vaccine-induced harm that have surfaced ever since their widespread use, beginning with the FDA's 2006 approval of Merck & Co.'s Gardasil.[i]
The study points out, "Along with the introduction of the HPV vaccines, several cases of onset or exacerbations of autoimmune diseases following the vaccine shot have been reported in the literature and pharmacovigilance databases, triggering concerns about its safety."
Following an extensive review of the biomedical literature, they listed conditions in which HPV vaccination is most likely linked to the development of autoimmune diseases (with qualification that they are only raising possible links and not fully confirmed ones), including:
- Acute disseminated encephalomyelitis and other demyelinating diseases of the central nervous system
- Multiple sclerosis (MS)
- Guillain–Barré syndrome (GBS)
- Primary ovarian failure (POF)
- IgA bullosus dermatitis
- Henoch-Schonlein purpura
- Cutaneous vasculitis
- Kikuch-Fujimoto disease
- Erythema multiforme
- Acute cerebral ataxia
- Immune thrombocytopenic purpura
The authors caution that, "The decision to vaccinate with HPV vaccine is a personal decision, not one that must be made for public health. HPV is not a lethal disease in 95% of the infections; and the other 5% are detectable and treatable in the precancerous stage."
HPV Vaccines May Cause The Immune System To Attack Body
How could a vaccine that has been declared safe and effective the world over be connected to such a wide range of autoimmune diseases?
Part of the explanation lies with a phenomena known as 'molecular mimicry,' defined as the possibility that the immune system will mistake a self-structure with a foreign (usually pathogen derived) peptide and thereby cause auto-immune harm. Antibodies, for instance, which are produced against a specific pathogen can cross-react with proteins in the body that have a similar or identical sequence.
Exactly this possibility is addressed in a groundbreaking article titled, "Quantifying the possible cross-reactivity risk of an HPV16 vaccine," published in 2009 in the Journal of Experimental Therapeutics and Oncology. The article describes the background for the topic as follows:
"The potential adverse events associated with vaccination for infectious diseases underscore the need for effective analysis and definition of possible vaccine side effects. Using the HPV16 proteome as a model, we quantified the actual and theoretical risks of anti-HPV16 vaccination, and defined the potential disease spectrum derived from concomitant cross-reactions with the human organism."
The HPV16 proteome is the entire spectrum of proteins produced by the HPV16 virus, which are present within both the Gardasil and Cervarix HPV vaccines. Each protein carries a risk of inducing an immune response that could, in theory, 'blow back' on self-structures within the human proteome. With this possibility in mind, the researchers used the following method to ascertain the likelihood of such an event:
"We searched the primary sequence of the HPV16 proteome for heptamer amino acid sequences shared with human proteins using the Protein International Resource database."
Heptamer amino acid sequences are defined as an oligomers (molecular complex) with seven subunits.
The results of their search revealed a profound degree of matching:
"The human proteome contains 82 heptapeptides and two octapeptides found in HPV16. The viral matches are spread among proteins involved in fundamental processes, such as cell differentiation and growth and neurosensory regulation. The human proteins containing the HPV16-derived heptamers include cell-adhesion molecules, leukocyte differentiation antigens, enzymes, proteins associated with spermatogenesis, transcription factors, and neuronal antigens. The number of viral matches and their locations make the occurrence of side autoimmune cross-reactions in the human host following HPV16-based vaccination almost unavoidable." [emphasis added]
The so-called "unavoidability" of "side autoimmune cross reactions in the human host following HPV16-based vaccination" is a huge concern, especially considering that there are 4 strains in total in the Gardasil vaccine and 2 in the Cervarix, increasing the range of proteomic overlap between viral and human proteins and subsequent molecular mimicry significantly. Also, it is important to acknowledge that the vaccine has never even been found to prevent one single case of death from cervical cancer, and yet millions are being exposed to what are likely its unavoidable health risks.
HPV Vaccines Don't Work As Advertised and Lack Safety
In an article published in 2013 in the journal Infectious Agent Cancer, titled "HPV vaccines and cancer prevention, science versus activism," the rationale behind current worldwide HPV vaccination programs is called into question.