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Brain On Fire: Pregnancy, Vaccines & Autism

Brain On Fire: Pregnancy, Vaccines & Autism

Vaccines currently recommended during pregnancy include the flu shot and the pertussis vaccine (Tdap).  What is the link between prenatal vaccines and autism?  This is the question that we will explore.

Whooping Cough: The Reality Behind the Myth

I like to watch a little bit of mainstream news to keep abreast of the information, or misinformation, being fed to the general public.   A few nights ago I saw a report on the evening news effectively blaming unvaccinated kids for the 2010 outbreak of whooping cough in my home state of California based on a retrospective study published recently in the journal Pediatrics.  The next morning headlines read "Anti-vaccine parents caused California's lethal whooping cough epidemic" and "Unvaccinated children helped fuel whooping cough outbreak, data show."  Let's start from the beginning.

There were reports of outbreaks starting in the 16th century but Bordetella pertussis was not isolated until 1906. [1]  Whooping cough is a toxin-mediated disease associated most commonly with the gram-negative bacterium B. pertussis and the lesser-known B. parapertussis.  The bacterium attaches to the cilia (hair like projections) of the epithelial cells in respiratory tract and produce multiple antigens including pertussis toxin (PT), filamentous hemagglutinin (FHA) and adenylate cyclase toxin (ACT).   These antigens work together to evade host defenses and paralyze the cilia inhibiting the host's ability of the to clear pulmonary secretions.  The incubation period can last from 4-42 days. [1]

A symptomatic infection can run through three classic stages.  The first is the catarrhal stage in which the person exhibits symptoms similar to the common cold including runny nose, sneezing, low-grade fever and mild cough.  The cough may gradually increase in severity over the course of 1-2 weeks leading to the second stage referred to as the paroxysmal stage.   The person has sudden bursts, or paroxysms, of coughs that occur more frequently at night.  The rapid succession of coughs, which may result in cyanosis (turning blue), emesis (vomiting) and exhaustion, is a labor-intensive attempt to expel thick mucous from the lungs.  At the end of a prolonged coughing spell, a quick inspiratory effort infrequently creates the characteristic high-pitched whooping sound.  This stage may last up to 10 weeks. [1]  In the convalescent stage, the cough gradually reduces in frequency and severity. 

Symptomatic Bordetella infections that progress into the paroxysmal stage can cause serious complications in very young infants who have a relatively small trachea and who haven't learned to optimally engage their abdominal muscles during coughing.  A lack of maternal protection from breast-feeding and suboptimal care increase the likelihood of a severe course.  The most common cause of death is from a bacterial co-infection resulting in pneumonia. [1] Although health officials like to portray severe sequelae as a common occurrence, presumably to increase vaccine uptake, most cases are relatively mild [26] or completely asymptomatic.

"Rates of reported pertussis are 40- to 60-fold less than actual illness rates, and asymptomatic infections are 4-22 times more common than symptomatic infections." [18]

"...B. pertussis has repeatedly been isolated from symptomless individuals (Broome et al. 1979, Broome et al. 1981; Lambert 1965; PHLS, 1969)." [17]

A nationwide vaccination program was started using the DPT (Diphtheria toxoid, Tetanus toxoid, whole-cell Pertussis) vaccine in the 1940's but not before whooping cough deaths had fallen by more than 92 percent in the United States from its peak in the early 1900s. [6,11] 

Data from England and Wales showed that mortality from whooping cough had declined by more than 99 percent before the use of the vaccine. [11] 

In the years following, doctors began questioning the wisdom and safety of the pertussis vaccination program in major medical journals.

"...it may be questioned whether universal vaccination against pertussis is always justified, especially in view of the increasingly mild nature of the disease and of the very small mortality...An investigation of the incidence of neurological complications after pertussis showed that this was not so high as after vaccination." [7]

"...whooping cough (and measles) are no longer important causes of death or severe illness...I cannot see how it is justifiable to promote mass vaccination of children everywhere against diseases which are generally mild, which confer lasting immunity, and which most children escape or overcome easily without being vaccinated." [8]

"This risk [of neurological damage from the vaccine] far exceeds the present risk of death or permanent damage from whooping-cough or even, in some parts of the country, the chance of contracting it." [9]

"...the risk of pertussis vaccine during the period 1970-83 exceeded those of whooping cough." [31]

The effectiveness of the DPT vaccine was also called into question.

"Immunization records revealed that 74 percent (75 of 101) of the children with pertussis who were 19 months to 12 years old had received four or five doses of the...(DPT) vaccine, and that 82 percent (103 0f 126) of those 7-71 months old had received at least three doses of DPT vaccine." [30]

DTaP replaced DPT in the mid-1990s.  Today, the CDC recommends the DTaP (Diphtheria toxoid, Tetanus toxoid, acellular Pertussis) vaccine at 2 months, 4 months, 6 months, 15-18 months and 4-6 years.  They also recommend a Tdap (Tetanus toxoid, reduced diphtheria toxoid, reduced acellular pertussis) booster at 11-12 years.  Recently the CDC began recommending a Tdap for post-partum moms prior to hospital discharge to protect newborns but research shows this practice to be ineffective. [28,34]

"Immunizing only postpartum mothers with Tdap vaccine did not reduce pertussis illness in infants ≤6 months of age." [28]

"Adolescent and/or adult vaccination seems to be cost-effective, however data from observational studies suggest that this vaccination strategy...does not affect the disease incidence in infants." [34]

During the statewide "epidemic" in California in 2010, the incidence was 20 cases per 100,000. [2]  All 10 deaths reported were in infants <3 months.  Although I do not have access to the infants' records, I presume all received the standard antibiotic treatment, which can prevent communicability [29] but may prolong and increase the severity of the illness. [25]

"Children who received an antibiotic had a duration of cough 6 to 11 days longer and spasmodic cough 4 to 13 days longer than untreated patients."   [25]

The recent study that generated headlines examined areas with clusters of non-medical exemptions (NMEs) based on kindergarten records and areas with clusters of confirmed, probable, and suspected pertussis cases based on reports to the California Department of Public Health (CDPH).  The map below comes directly from the published article. 

The analysis found an association between clusters of pertussis cases and NMEs, however, the data shows large regions where no association existed.  Keep in mind that specificity of a pertussis infection diagnosis can be poor, with high rates of false-positive results in some laboratories due to factors that include being vaccinated against pertussis. [1] 

The authors reference numerous weaknesses in the data including the fact that a NME did not necessarily indicate that the individuals were unvaccinated.

"NME data from California do not contain specific data on which vaccine(s) or dose(s) were not received by a child with a NME, and it is possible that some children with a NME were completely vaccinated against pertussis."  [4]

Furthermore, they acknowledge that they did not know if the confirmed pertussis cases in these clusters were up-to-date on their vaccinations.

"Immunization status of cases was not available for a large enough proportion of the pertussis cases to include this variable in our analysis." [4]

A study published in 2012 in the journal Clinical Infectious Diseases analyzed data from a Kaiser Permanente database in Marin County, California which had the 2nd highest incidence of lab confirmed pertussis in the state at 136 per 100,000. [2] 

"Of the 132 individuals aged ≤18 years at time of illness, 81% were fully vaccinated, 11% were undervaccinated, and 8% were never vaccinated...Our unvaccinated and undervaccinated population did not appear to contribute significantly to the increased rate of clinical pertussis.  Surprisingly, the highest incidence of disease was among previously vaccinated children aged 8-12 years...Surprisingly, in the 2-7 and 8-12 age groups, there was no significant difference in attack rates between fully vaccinated children and both undervaccinated and unvaccinated children..." [3]

In a 2012 study published in the Journal of Pediatric Infectious Disease, they looked at the data from San Diego, CA during the 2010 outbreak.

"Pertussis vaccine effectiveness may decrease more rapidly than previously believed, facilitating spread of pertussis in elementary school-aged children." [5]

In another 2012 study in the New England Journal of Medicine, the authors state:

"In conclusion, our evaluation of data from a large pertussis outbreak in California [in 2010] showed that protection from disease after a fifth dose of DTaP...was relatively short-lived and waned substantially each year." [10]

These studies found that appropriately vaccinated kids can acquire and spread whooping cough due to primary (no initial protection) or secondary (waning protection) vaccine failure.

"Among 176 confirmed cases of infants with pertussis...77% were age-appropriately vaccinated." [33]

"Vaccine effectiveness...was determined to be 41%, 24%, 79%, and 51% for patients aged 2-7 years, 8-12 years, 13-18 years, and 2-18 years, respectively." [3]       

"Despite underreporting, an increased incidence of infant, adolescent and adult pertussis has been observed worldwide since the introduction of widespread vaccination." [32]

The aforementioned study alludes to the fact that the data fails to capture individuals who were infected but were not counted because 1) they were asymptomatic, 2) their lab results showed a false-negative, or 3) they were overlooked by parents and physicians due to mild symptoms and an inflated belief in the protection afforded by the vaccine.

Measles: A Rash of Misinformation

Measles Vaccines Questions

With the recent release of a provocative children's book entitled Melanie's Marvelous Measles, a debate has ensued regarding the effectiveness and wisdom surrounding measles vaccinations.  When I first heard about the book, I went to Amazon to order a copy for myself.  The amount of negative reviews was staggering.  People were claiming that the information was "dangerous", "harmful" and "ill-informed".  Some were even calling for the book to be banned.  It took me a few minutes to read it from cover to cover.  Rather than critique the book, which has already been done quite eloquently by others, I would like to talk about the widespread fear surrounding measles and the misinformation regarding the vaccine. 

The Hidden Connection Behind Viruses, Vaccines and Cancer

The Hidden Connection Behind Viruses, Vaccines and Cancer

Mainstream medicine tells us that the hepatitis B virus (HBV) causes liver cancer which is why it is so necessary for US newborns to be vaccinated within hours of birth.  We are told that the human papillomavirus (HPV), which is supposedly so prevalent in our population, causes cervical cancer which is why there is such a push to vaccinate girls and boys in the US as early as 9 years old. Let's not forget about Simian Virus 40 (SV40) which is known to have contaminated polio vaccines and is associated with a wide variety of human cancers.  Conventional wisdom tells us that viruses cause cancer.  But is this true? Let's investigate the story further.

The first recorded cases of HBV infection occurred following the administration of the smallpox vaccine containing human lymph to shipyard workers in Germany in 1883. HBV is transmitted through contact with infected bodily fluids.  It is estimated that over 2 billion people worldwide have been infected and that approximately 350 million are chronic carriers.  Chronic HBV infection is believed to cause up to 80% of all hepatocellular carcinomas.  Sounds scary right?  But when you look deeper you find that, in the US, HBV is found predominantly in adults who are either I.V. drug users or engaging in high-risk sexual behavior.

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