Polyphenols

Notice: Articles are Alphabetized According to Ailments
Quick Access: Other Therapeutic Actions
Ailments Studied

Green tea drinking suppresses proliferation of HTLV-1-infected lymphocytes in vivo.

Study Type : Human Study
Additional Links:
Substances : Green Tea
Pharmacological Actions : Antiviral Agents

Cyperus rotundus suppresses AGE formation and protein oxidation in a model of fructose-mediated protein glycoxidation.

Study Type : Animal Study
Additional Links:
Pharmacological Actions : Antioxidants
Additional Keywords : Plant Extracts

Onion flesh and onion peel enhance antioxidant status in aged rats.

Study Type : Animal Study
Additional Links:
Substances : flavonoids, Onion, Quercetin
Diseases : Aging, DNA damage
Pharmacological Actions : Antioxidants
Additional Keywords : Plant Extracts

Grape seed extract has inhibiting effect on the accumulation of age-related oxidative DNA damages in the central nervous system of rats.

Study Type : Animal Study
Additional Links:
Substances : flavonoids
Pharmacological Actions : Antioxidants, Neuroprotective Agents
Additional Keywords : Plant Extracts, Proanthocyanidins

Blackberries improve motor and cognitive performance in aged rats.

Study Type : Animal Study
Additional Links:
Substances : Blackberry, flavonoids

Plant polyphenols may be useful in skin diseases associated with solar UV radiation-induced inflammation, oxidative stress and DNA damage.

Study Type : Commentary
Additional Links:

A polyphenol and antioxidant rich fruit and vegetable concentrate has therapeutic value in HIV patients due to enhanced proliferation, which could restore disturbances in T-cell homeostasis.

Study Type : Human Study
Additional Links:
Diseases : AIDS, HIV Infections
Pharmacological Actions : Antioxidants, Immunomodulatory

Fenugreek (Trigonella foenum graecum) seed polyphenols protects the liver from alcohol toxicity.

Study Type : Animal Study
Additional Links:
Substances : Fenugreek, flavonoids
Pharmacological Actions : Phase II Detoxification Enzyme Inducer
Additional Keywords : Plant Extracts

Fenugreek seed polyphenols inhibit ethanol-induced damage in the rat liver.

Study Type : Animal Study
Additional Links:
Substances : Fenugreek
Pharmacological Actions : Hepatoprotective
Additional Keywords : Plant Extracts

Green tea polyphenol is able to attenuate alcoholic liver damage.

Study Type : Animal Study
Additional Links:
Substances : flavonoids, Green Tea
Pharmacological Actions : Hepatoprotective

Procyanidin-enriched apple extract exhibits anti-allergic properties.

Study Type : In Vitro Study
Additional Links:
Substances : Apples
Diseases : Allergies
Pharmacological Actions : Anti-Allergic Agents
Additional Keywords : Plant Extracts, Proanthocyanidins

Tea polyphenols contributes to significant hair regrowth in rodents experiencing spontaneous hair loss.

Study Type : Animal Study
Additional Links:
Substances : Green Tea
Diseases : Alopecia, Hair Loss

Blueberry polyphenols may reduce neurodegenerative diseases.

Study Type : Animal Study
Additional Links:
Substances : Blueberry
Pharmacological Actions : Neuroprotective Agents

Polyphenols such as curcumin and EGCG from green tea may chelate out iron from the Alzheimers brain.

Study Type : Commentary
Additional Links:

Tea polyphenols mitigate arsenic toxicity in human lymphocytes.

Study Type : In Vitro Study
Additional Links:
Substances : Black Tea, Green Tea
Pharmacological Actions : Antioxidants
Additional Keywords : Plant Extracts

Tea polyphenols mitigate arsenic toxicity in mammalian cells.

Study Type : In Vitro Study
Additional Links:
Substances : Black Tea, Green Tea
Pharmacological Actions : Antioxidants
Additional Keywords : Plant Extracts

Pomegranate juice consumption appears to slow the progression of the carotid intima-media thickness in subjects with increased oxidative stress and poor blood lipid profiles.

Study Type : Human Study
Additional Links:
Pharmacological Actions : Anti-atherogenic, Antioxidants

Wine consumption reduces TNF-apha-induced adhesion of monocytes to endothelial cells.

Study Type : Human Study
Additional Links:
Substances : flavonoids, Wine

The Mediterranean diet, which includes a combination of antioxidant compounds and flavonoid-rich foods, appears effective to decrease LDL particle oxidizability, which reduces the risk for cardiovascular disease.

Study Type : Human Study
Additional Links:
Substances : flavonoids
Pharmacological Actions : Antioxidants

Olive leaf has a wide range of therapeutic applications.

Study Type : Review
Additional Links:
Diseases : Arteriosclerosis
Additional Keywords : Plant Extracts

Olive oil and red wine antioxidant polyphenols at nutritionally relevant concentrations transcriptionally inhibit endothelial adhesion molecule expression, thus partially explaining atheroprotection from Mediterranean diets.

Study Type : In Vitro Study
Additional Links:

Apple fibers and polyphenols may play a role in preventing artherosclerosis by decreasing uric acid plasma level.

Study Type : Animal Study
Additional Links:
Substances : Apples, Fiber, flavonoids
Pharmacological Actions : Antioxidants
Additional Keywords : Plant Extracts

Green tea polyphenols and its constituent EGCG inhibits proliferation of human breast cancer cells in vitro and in vivo.

Study Type : Animal Study
Additional Links:
Diseases : Breast Cancer

Green tea polyphenol and EGCG induce programmed cell death and inhibit invasion in human breast cancer cells.

Study Type : Animal Study
Additional Links:
Substances : Catechin , flavonoids

Extra-virgin olive oil polyphenols may inhibit breast cancer through interfering with fatty acid synthesis.

Study Type : In Vitro Study
Additional Links:
Substances : Olive
Diseases : Breast Cancer

Oleuropein and hydroxytyrosol, two polyphenols contianed within extra-virgin olive oil, inhibit MCF-7 breast cancer cell proliferation.

Study Type : In Vitro Study
Additional Links:
Diseases : Breast Cancer
Pharmacological Actions : Antiproliferative , Chemopreventive

Blueberry inhibits the growth and metastatic potential of triple negative breast cancer in vitro and in vivo.

Study Type : Animal Study
Additional Links:
Substances : Blueberry, flavonoids
Additional Keywords : Plant Extracts

Green tea has a growth inhibitory and antimetastatic effect on metastasis-specific mouse mammary cancer.

Study Type : Animal Study
Additional Links:
Substances : flavonoids, Green Tea
Pharmacological Actions : Anti-metastatic, Antiproliferative , Apoptotic

The dietary flavonoids ECGC, luteolin, quercetin, kaempferol, apigenin, and taxifolin inhibit cancer cell lipogenesis.

Study Type : In Vitro Study
Additional Links:
Diseases : Cancers
Pharmacological Actions : Antiproliferative , Apoptotic

Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate.

Study Type : Human Study
Additional Links:
Substances : flavonoids

Olive oil consumption in the Mediterranean diet may be largely responsible for its positive effect on reduced cardiac mortality and oxidative damage.

Study Type : Commentary
Additional Links:
Substances : flavonoids, Olive
Pharmacological Actions : Antioxidants

Polyphenols from olive exhibit anti-platelet activity which is associated with the cardiovascular benefits of the Mediterranean diet.

Study Type : Commentary
Additional Links:
Pharmacological Actions : Anti-Platelet, Antioxidants
Additional Keywords : Plant Extracts

Edible seaweed has antixoidant and antiproliferative activity against cervical cancer cell lines.

Study Type : In Vitro Study
Additional Links:
Substances : flavonoids, Seaweed
Diseases : Cervical Cancer

Extracts from dulse (Palmaria palmata) are effective antioxidants and inhibitors of cell proliferation in vitro.

Study Type : In Vitro Study
Additional Links:
Substances : Dulse, flavonoids, Seaweed
Diseases : Cervical Cancer
Pharmacological Actions : Antioxidants, Antiproliferative

Walnut polyphenols prevent chemically-induced liver damage .

Study Type : Animal Study
Additional Links:
Pharmacological Actions : Hepatoprotective

Polyphenols from bees wax exhibit hepatoprotective and antioxidative properties.

Study Type : Animal Study
Additional Links:
Substances : Beeswax
Pharmacological Actions : Antioxidants, Hepatoprotective

Green teaGreen tea polyphenol administration partly ameliorates irinotecan chemotherapy-induced side effects in the small intestine of mice.

Study Type : Animal Study
Additional Links:
Pharmacological Actions : Antineoplastic Agents

Various plant polyphenols have antichlamydial activity.

Study Type : In Vitro Study
Additional Links:
Pharmacological Actions : Anti-Infective Agents

Apple polyphenol may reduce the adverse effects of the immunization adjuvant cholera toxin.

Study Type : Animal Study
Additional Links:
Substances : Apples
Additional Keywords : drug side effect attenuation

Continuous intake of polyphenolic compounds containing cocoa powder reduces LDL oxidative susceptibility and has beneficial effects on plasma HDL-cholesterol concentrations in humans.

Study Type : Human Study
Additional Links:
Substances : Catechin , flavonoids
Pharmacological Actions : Antioxidants

Pine need extract is anti-inflammatory and has a protective effect on cholesteorl oxidation.

Study Type : Animal Study
Additional Links:
Substances : flavonoids, Pine Needle

A grape seed extract rich in procyanidins achieves direct and indirect (i.e. cell-mediated) protection of LDL against oxidation.

Study Type : In Vitro Study
Additional Links:
Pharmacological Actions : Antioxidants
Additional Keywords : Plant Extracts

Antioxidant therapy may be an effective treatment in COPD.

Study Type : Commentary
Additional Links:

Pomegrante contains compounds with antiproliferative, apoptotic and antioxidant activites against various cancer cell lines.

Study Type : In Vitro Study
Additional Links:
Additional Keywords : Plant Extracts

Apples may exert their colon cancer protective effects through favorably altering gene patterns resulting in protection of cells against toxicological insults.

Study Type : Animal Study
Additional Links:
Substances : Apples, flavonoids
Diseases : Colon Cancer
Pharmacological Actions : Chemopreventive
Additional Keywords : epigenetic modification

Olive oil polyphenols inhibit human colon cancer cell proliferation.

Study Type : In Vitro Study
Additional Links:
Diseases : Colon Cancer

A polyphenolic-rich blueberry extract can inhibit Giardia duodenalis and Cryptosporidium parvum.

Study Type : In Vitro Study
Additional Links:
Substances : Blueberry, flavonoids
Pharmacological Actions : Antiprotozoal Agents
Additional Keywords : Plant Extracts

Cocoa polyphenol has an antidepressant-like effect in rats.

Study Type : Animal Study
Additional Links:
Substances : flavonoids
Pharmacological Actions : Antidepressive Agents
Additional Keywords : Plant Extracts

Polyphenols may have therapeutic value in a variety of diseases through modulating AMP-activated protein kinase which reduce fatty acid and cholesterol synthesis and gluconeogenesis.

Study Type : Commentary
Additional Links:

Olive oil, hydroxytyrosol and other olive phenolic compounds inhibit oxidaitve DNA damage in human blood mononuclear cells.

Study Type : In Vitro Study
Additional Links:
Substances : Hydroxytyrosol, Olive
Pharmacological Actions : Antioxidants

Dietary unripe apple polyphenol inhibits the development of food allergies in the mouse model.

Study Type : Animal Study
Additional Links:
Diseases : Food Allergies
Additional Keywords : Proanthocyanidins

Polyphenol-rich olives induce programmed cell death in gastric cancer cells.

Study Type : In Vitro Study
Additional Links:
Substances : Olive
Diseases : Gastric Cancer
Pharmacological Actions : Apoptotic

An aqueous decoction of mango flowers has potential gastroprotective and ulcer-healing properties.

Study Type : Animal Study
Additional Links:
Substances : flavonoids, Mango
Diseases : Gastric Ulcer
Pharmacological Actions : Anti-Ulcer Agents, Cyclooxygenase Inhibitors
Additional Keywords : Plant Extracts

Mango leaves hae antioxidant and antiulcerogenic action.

Study Type : Animal Study
Additional Links:
Diseases : Gastric Ulcer
Pharmacological Actions : Anti-Ulcer Agents
Additional Keywords : Xanthones

Various natural substances may prove useful in the treatment of glaucoma.

Study Type : Commentary
Additional Links:
Diseases : Glaucoma

Resveratrol induces programmed cell death in human glioma cells.

Study Type : In Vitro Study
Additional Links:
Substances : flavonoids, Resveratrol
Diseases : Glioma
Pharmacological Actions : Apoptotic, Cell cycle arrest, Enzyme Inhibitors
Additional Keywords : Stilbenes

Apple peel extract inhibits the growth of Helicobacter pylori, and attenuates damage to the gastric mucosa caused by neutrophils.

Study Type : Human Study
Additional Links:
Substances : Apples, flavonoids
Additional Keywords : Plant Extracts, Proanthocyanidins

Grape and wine extracts have antibacterial activity against Helicobacter pylori clinical isolates.

Study Type : In Vitro Study
Additional Links:
Pharmacological Actions : Anti-Bacterial Agents, Antioxidants
Additional Keywords : Plant Extracts

The apple polyphenol phloretin potentiates the anticancer actions of paclitaxel against human hepatoma cells.

Study Type : In Vitro Study
Additional Links:
Substances : Apples, Phloretin
Diseases : Hepatoma
Pharmacological Actions : Apoptotic
Additional Keywords : drug synergy

A Mediterranean diet may protect against homocysteine-induced cardiovascular damage.

Study Type : Commentary
Additional Links:
Additional Keywords : Stilbenes

Plasma antioxidant capacity can be increased by long-term ingestion of polyphenols from fruit juices or fruit-vegetable-concentrate in HIV-seropositive patients.

Study Type : Human Study
Additional Links:
Diseases : HIV Infections
Pharmacological Actions : Antioxidants

A combination of Lysine, Proline, Vitamin C, Arginine, Polyphenols, NAC (N-acetyl-L-cysteine), Selenium, Copper, Manganese induces apoptosis in HTLV-1 positive and negative malignant T-cells.

Study Type : In Vitro Study
Additional Links:
Pharmacological Actions : Apoptotic
Additional Keywords : Antineoplastic Agents

Licorice has hypocholesterolaemic and antioxidant effects.

Study Type : Animal Study
Additional Links:
Substances : flavonoids, Licorice
Pharmacological Actions : Anticholesteremic Agents, Antioxidants

Persimmon peel polyphenol has a protective effect against high glucose-induced oxidative stress, in vitro.

Study Type : In Vitro Study
Additional Links:
Substances : flavonoids, Persimmon
Pharmacological Actions : Antioxidants, NF-kappaB inhibitor

Tarragon (Artemisia d.) contains polyphenolic compounds which have insulin-mimetic and gluconeogenesis inhibitory activity.

Study Type : In Vitro Study
Additional Links:
Substances : flavonoids, Tarragon
Diseases : Hyperglycemia
Additional Keywords : Plant Extracts

Acerola fruit polyphenol has a skin-lightening effect on UV-induced pigmentation.

Study Type : In Vitro Study
Additional Links:
Substances : Acerola
Pharmacological Actions : Tyrosinase inhibitors
Additional Keywords : Plant Extracts

Apples rich polyphenols reduce colonic inflammation in rats.

Study Type : Transgenic Animal Study
Additional Links:
Substances : Apples, flavonoids

Fenugreek seed polyphenolic extract and quercetin compares favorably to metformin in improving insulin signaling, sensitivity and functioning in a rat model.

Study Type : Animal Study
Additional Links:
Substances : Fenugreek

Green tea prevents and reverses fasting-induced intestinal mucosal damage.

Study Type : Animal Study
Additional Links:
Substances : flavonoids, Vitamin E
Therapeutic Actions : Fasting/Caloric Restriction
Pharmacological Actions : Antioxidants

Various plant polyphenols inhibit lung cancer caused by metastatic melanoma.

Study Type : Animal Study
Additional Links:

An extract of evening primrose (O. paradoxa) exhibits pro-oxidative and pro-apoptic against human skin melanoma cells.

Study Type : In Vitro Study
Additional Links:
Diseases : Melanoma
Pharmacological Actions : Apoptotic
Additional Keywords : Plant Extracts

Embelia ribes has a cardioprotective effect against isoproterenol-induced myocardial infarcation in rats.

Study Type : Animal Study
Additional Links:
Pharmacological Actions : Antioxidants, Cardioprotective
Additional Keywords : Plant Extracts

Strawberry phenolic compounds have antioxidant and anti-cancer activity against human prostate and oral cancer cell lines.

Study Type : In Vitro Study
Additional Links:
Substances : Strawberry
Pharmacological Actions : Anticarcinogenic Agents, Antioxidants

Milk thistle sprouts have significant antioxidant value which increases with light exposure.

Study Type : Animal Study
Additional Links:
Diseases : Oxidative Stress
Therapeutic Actions : Light Therapy
Pharmacological Actions : Antioxidants

The food-derived polyphenols quercetin, trans-resveratrol and genistein inhibit pancreatic cancer growth and prevent metastasis, in vitro.

Study Type : In Vitro Study
Additional Links:
Pharmacological Actions : Apoptotic
Additional Keywords : natural substance synergy

A cocoa-enriched diet prevents gingival oxidative stress in experimental periodontitis.

Study Type : Animal Study
Additional Links:
Substances : Cocoa, flavonoids
Diseases : Periodontitis

Green tea polyphenols have an anti-proliferative and proapoptic effect on human promyelocytic leukemia cells.

Study Type : In Vitro Study
Additional Links:
Substances : Green Tea

Tea polyphenols (primarily EGCG), significantly reduce PSA, Hepatocyte growth factor, VEG in men with prostate cancer.

Study Type : Human Study
Additional Links:

Various plant phenolics inhibit neutrophil elastase which may have a beneficial role in the treatment of psoriasis.

Study Type : In Vitro Study
Additional Links:
Diseases : Psoriasis

Coffee appears to have a beneficial effect on pulmonary function, among non-smokers.

Study Type : Human Study
Additional Links:
Substances : Coffee, flavonoids

Polyphenols have a therapeutic role in the prevention and treatment of sepsis syndromes.

Study Type : Commentary
Additional Links:
Diseases : Sepsis
Pharmacological Actions : NF-kappaB inhibitor
Back to Top
Other Relevant Articles

Citrus polyphenol extract contributes to fat-burning and may help to prevent obesity.

Hops contains polyphenols which suppress plaque growth caused by Streptococcus mutans.

Hops polyphenols reduce dental plaque growth in humans.

Polyphenols have a variety of cardioprotective properties/actions.

""