Myotoxicity

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10 Problem Substances Researched for Myotoxicity
59 Diseases Researched for Myotoxicity
NameACCKFocus
Statin-Induced Pathologies63255Locked
Myopathies38160Locked
Rhabdomyolysis1551Locked
Myalgias744Locked
Creatine Phosphokinase (CK): Elevated542Locked
Muscle Damage: Exercise-Induced431Locked
Athletic Performance330Locked
Mitochondrial Dysfunction 827Locked
Drug-Induced Nutrient Depletion: Statin Drugs921Locked
Coenzyme Q10 Deficiency415Locked
Drug-Induced Toxicity 314Locked
Muscle Disorders213Locked
Polymyalgia Rheumatica213Locked
Mitochondrial Myopathies312Locked
Muscle Soreness211Locked
Blood Lactate/ Pyruvate Ratio: Elevated110Locked
Death: Statin-Induced110Locked
GGT110Locked
Isoprostane 8-epi-PGF2alpha: Elevated110Locked
Muscle Fatigue110Locked
Muscle Soreness: Exercise-Induced110Locked
Muscle Stiffness: Exercise-Induced110Locked
Organ Transplantation: Heart110Locked
Oxidative Stress110Locked
Dermatomyositis26Locked
Congestive Heart Failure24Locked
Myositis24Locked
Skeletal Muscle: Changes to MHC I expression24Locked
Elevated: Creatinine Kinase13Locked
Hepatitis: Acute13Locked
Hyperlipidemia13Locked
Hypersensitivity13Locked
Hypothyroidism13Locked
Kidney Transplant13Locked
Myoglobinuria13Locked
Neuroleptic Malignant Syndrome13Locked
Neuromuscular Diseases13Locked
Pneumonitis13Locked
Pneumonitis: Hypersensitivity Type13Locked
Polymyositis13Locked
Presymptomatic Metabolic Myopathy 13Locked
Rhabdomyolysis: Fatal13Locked
Skeletal Muscle Changes: Endoplasmic Reticulum Stress13Locked
Brain Damage12Locked
Cardiovascular Diseases12Locked
Heart Failure12Locked
Hypertension12Locked
Liver Damage: Drug-Induced12Locked
Mineral Deficiencies: Selenium22Locked
Myocardial Ischemia12Locked
Testicular Diseases12Locked
Coronary Artery Disease11Locked
High Cholesterol11Locked
Kidney Damage: Drug-Induced11Locked
Kidney Failure11Locked
Lipid Peroxidation11Locked
Myopathy: Iatrogenic11Locked
Neuromyotoxicity11Locked
Skeletal Muscle Changes: Ultrastructural Changes11Locked

View the Evidence:
80 Abstracts with Myotoxicity Research

[+]
Pubmed Data : Curr Opin Lipidol. 2007 Aug;18(4):401-8. PMID: 17620856
Study Type : Meta Analysis
Additional Links
Diseases : Myopathies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Neuro Endocrinol Lett. 2012 Nov 28 ;33(Suppl2):98-101. Epub 2012 Nov 28. PMID: 23183519
Study Type : Human Study
Additional Links
Substances : Coenzyme Q10
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Br J Clin Pharmacol. 2004 Apr ;57(4):525-8. PMID: 15025753
Study Type : Human Study
Additional Links
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Toxicol Sci. 2005 Dec ;88(2):551-61. Epub 2005 Sep 1. PMID: 16141437
Study Type : Human Study
[+]
Pubmed Data : Clin Pharmacol Ther. 2006 Jun ;79(6):532-9. PMID: 16765141
Study Type : Human Study
Additional Links
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Metabolism. 1997 Oct ;46(10):1206-10. PMID: 9322808
Study Type : Human Study
[+]
Pubmed Data : J Clin Pharm Ther. 2001 Aug ;26(4):303-10. PMID: 11493374
Study Type : Human Study
[+]
Pubmed Data : Curr Med Res Opin. 2012 Jun 11. Epub 2012 Jun 11. PMID: 22686958
Study Type : Human Study
Additional Links
Diseases : Myopathies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Cardiovasc Drugs Ther. 2003 Sep-Nov;17(5-6):459-65. PMID: 15107601
Study Type : Human Study
Additional Links
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Transplant Proc. 2005 Nov ;37(9):4071-3. PMID: 16386629
Study Type : Human Study
Additional Links
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Atorvastatin, Pravastatin , Statin Drugs
Adverse Pharmacological Actions : Hepatotoxic, Myotoxicity
[+]
Pubmed Data : Arch Intern Med. 2005 Dec 12-26;165(22):2671-6. PMID: 16344427
Study Type : Human Study
Additional Links
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : J Pathol. 2006 Sep ;210(1):94-102. PMID: 16799920
Study Type : Human Study
Additional Links
Pharmacological Actions : Anticholesteremic Agents
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Am J Cardiovasc Drugs. 2010 ;10(3):187-92. PMID: 20524720
Study Type : Human Study
Additional Links
Problem Substances : Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Br J Clin Pharmacol. 1996 Sep ;42(3):333-7. PMID: 8877024
Study Type : Human Study
Additional Links
Pharmacological Actions : Enzyme Inhibitors
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Int J Cardiol. 2011 Aug 1. Epub 2011 Aug 1. PMID: 21813193
Study Type : Human Study
Additional Links
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : PLoS One. 2012 ;7(7):e41289. Epub 2012 Jul 23. PMID: 22844450
Study Type : Human Study
Additional Links
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Endocrine. 2009 Feb;35(1):38-46. Epub 2008 Dec 3. PMID: 19051066
Study Type : Human Study
Additional Links
Problem Substances : Lovastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Atherosclerosis. 2011 Jul 20. Epub 2011 Jul 20. PMID: 21868014
Study Type : Human Study
Additional Links
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Neurorehabil Neural Repair. 2005 Sep ;19(3):259-63. PMID: 16093417
Study Type : Human Study
Additional Links
Diseases : Myopathies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : J Submicrosc Cytol Pathol. 2004 Jan ;36(1):85-9. PMID: 15311678
Study Type : Human Study
Additional Links
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Am J Cardiol. 2011 Oct 27. Epub 2011 Oct 27. PMID: 22036108
Study Type : Human Study
Additional Links
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Rev Rhum Mal Osteoartic. 1992 Apr ;59(4):281-3. PMID: 1496277
Study Type : Human: Case Report
Additional Links
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Simvastatin
Adverse Pharmacological Actions : Cardiotoxic, Myotoxicity
[+]
Pubmed Data : Muscle Nerve. 2004 Dec ;30(6):803-7. PMID: 15389654
Study Type : Human: Case Report
Additional Links
Diseases : Dermatomyositis
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : J Intern Med. 1996 Dec ;240(6):403-4. PMID: 9010388
Study Type : Human: Case Report
Additional Links
Additional Keywords : Drug Synergy
Problem Substances : Fenofibrates, Gemfibrozil, Simvastatin
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Clin Ther. 2007 Jan ;29(1):172-6. PMID: 17379057
Study Type : Human: Case Report
Additional Links
Problem Substances : Pravastatin , Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Am J Med. 2000 Mar ;108(4):351-2. PMID: 11014734
Study Type : Human: Case Report
Additional Links
Problem Substances : Simvastatin
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Ann Dermatol Venereol. 2005 Dec ;132(12 Pt 1):996-9. PMID: 16446645
Study Type : Human: Case Report
Additional Links
Diseases : Dermatomyositis
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Fluvastatin
Adverse Pharmacological Actions : Myotoxicity
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nephrol Dial Transplant. 2000 May ;15(5):740-1. PMID: 10809833
Study Type : Human: Case Report
Additional Links
Anti Therapeutic Actions : Vaccination: All, Vaccination: Influenza
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Clin Neuropharmacol. 2009 Nov-Dec;32(6):348-9. PMID: 19952877
Study Type : Human: Case Report
Additional Links
Problem Substances : Simvastatin
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Chest. 1999 Mar ;115(3):886-9. PMID: 10084510
Study Type : Human: Case Report
Additional Links
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Recenti Prog Med. 1995 May ;86(5):198-200. PMID: 7604176
Study Type : Human: Case Report
Additional Links
Problem Substances : Pravastatin
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Rinsho Shinkeigaku. 2004 Jan ;44(1):25-7. PMID: 15199734
Study Type : Human: Case Report
Additional Links
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Pravastatin
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Ann Pharmacother. 2010 Dec ;44(12):1994-7. Epub 2010 Nov 2. PMID: 21045169
Study Type : Human: Case Report
Additional Links
Problem Substances : Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Heart. 2004 Jan ;90(1):e3. PMID: 14676266
Study Type : Human: Case Report
Additional Links
Problem Substances : Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Clin Chem. 1990 Dec ;36(12):2145-7. PMID: 2253372
Study Type : Human: Case Report
Additional Links
Problem Substances : Lovastatin
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Liver Transpl. 2011 Mar;17(3):331-3. PMID: 21384516
Study Type : Human: Case Report
Additional Links
Diseases : Rhabdomyolysis
Problem Substances : Rosuvastatin
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Neuromuscul Disord. 2007 Feb ;17(2):194-200. Epub 2007 Jan 22. PMID: 17241784
Study Type : Human: Case Report
[+]
Pubmed Data : Int J Clin Pharmacol Ther. 2005 Nov ;43(11):543-5. PMID: 16300170
Study Type : Human: Case Report
Additional Links
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Simvastatin
Adverse Pharmacological Actions : Myotoxicity, Nephrotoxic
[+]
Pubmed Data : Arch Intern Med. 2006 Jul 24 ;166(14):1519-24. PMID: 16864763
Study Type : Human: Case Report
Additional Links
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Can Fam Physician. 2007 Mar ;53(3):428-31. PMID: 17872677
Study Type : Human: Case Report
Additional Links
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Eur J Radiol. 2011 Feb ;77(2):258-60. Epub 2011 Jan 12. PMID: 21232890
Study Type : Human: Case Report
Additional Links
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Biochim Biophys Acta. 1994 Jul 6 ;1200(2):100-8. PMID: 8031828
Study Type : Animal Study
[+]
Pubmed Data : J Neuropathol Exp Neurol. 1993 Sep ;52(5):542-9. PMID: 8360706
Study Type : Animal Study
Additional Links
Problem Substances : Lovastatin
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Biosci Rep. 2010 Feb;30(1):41-50. Epub 2009 Oct 6. PMID: 19228123
Study Type : Animal Study
Additional Links
Problem Substances : Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Eur Heart J. 2011 Jul 20. Epub 2011 Jul 20. PMID: 21775390
Study Type : Animal Study
Additional Links
Substances : Quercetin
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Physiol Res. 2007;56 Suppl 2:S49-54. Epub 2007 Sep 5. PMID: 17824807
Study Type : Animal Study
[+]
Pubmed Data : Br J Pharmacol. 1995 Sep ;116(2):1894-8. PMID: 8528576
Study Type : Animal Study
[+]
Pubmed Data : J Muscle Res Cell Motil. 2011 Nov 9. Epub 2011 Nov 9. PMID: 22068225
Study Type : Animal Study
Additional Links
Problem Substances : Fluvastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Toxicol Pathol. 1996 Jul-Aug;24(4):468-76. PMID: 8864188
Study Type : Animal Study
Additional Links
Pharmacological Actions : Anticholesteremic Agents, Enzyme Inhibitors
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Hepatotoxic, Myotoxicity, Neurotoxic
[+]
Pubmed Data : Free Radic Biol Med. 2011 Oct 25. Epub 2011 Oct 25. PMID: 22080086
Study Type : In Vitro Study
Additional Links
Problem Substances : Simvastatin
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : J Pharmacol Sci. 2010;114(4):454-63. Epub 2010 Nov 26. PMID: 21127387
Study Type : In Vitro Study
Additional Links
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Bratisl Lek Listy. 2011 ;112(11):603-4. PMID: 22180983
Study Type : Review
[+]
Pubmed Data : Ochsner J. 2010 ;10(1):16-21. PMID: 21603349
Study Type : Review
Additional Links
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Am J Physiol Cell Physiol. 2006 Dec ;291(6):C1208-12. Epub 2006 Aug 2. PMID: 16885396
Study Type : Review
Additional Links
Pharmacological Actions : Anticholesteremic Agents, Apoptotic
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Toxicol Lett. 2012 Oct 20. Epub 2012 Oct 20. PMID: 23092657
Study Type : In Vitro Study
[+]
Pubmed Data : Ned Tijdschr Geneeskd. 2010 ;154:A1684. PMID: 21435278
Study Type : Review
Additional Links
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Expert Opin Drug Saf. 2006 Sep ;5(5):651-66. PMID: 16907655
Study Type : Review
Additional Links
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Cardiovasc Drugs. 2008 ;8(6):373-418. PMID: 19159124
Study Type : Review
Additional Links
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Expert Rev Cardiovasc Ther. 2008 Aug ;6(7):955-69. PMID: 18666846
Study Type : Review
Additional Links
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Muscle Nerve. 2005 May ;31(5):572-80. PMID: 15712281
Study Type : Review
Additional Links
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Ann Pharmacother. 2001 Sep ;35(9):1096-107. PMID: 11573861
Study Type : Review
Additional Links
Diseases : Rhabdomyolysis
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Biochim Biophys Acta. 2011 Aug 4. Epub 2011 Aug 4. PMID: 21839782
Study Type : In Vitro Study
Additional Links
Problem Substances : Simvastatin
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Curr Opin Neurol. 2010 Oct ;23(5):445-9. PMID: 20581681
Study Type : Review
Additional Links
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Toxicol Appl Pharmacol. 1995 Mar ;131(1):163-74. PMID: 7878672
Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Anticholesteremic Agents
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Drugs Today (Barc). 2005 Apr ;41(4):267-93. PMID: 16034491
Study Type : Review
Additional Links
Diseases : Neuromyotoxicity
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity, Neurotoxic
[+]
Pubmed Data : Curr Vasc Pharmacol. 2011 Oct 21. Epub 2011 Oct 21. PMID: 22022768
Study Type : Review
Additional Links
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity, Nephrotoxic
[+]
Pubmed Data : Toxicol Appl Pharmacol. 2004 Nov 1 ;200(3):237-50. PMID: 15504460
Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Apoptotic
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Lancet. 2004 Mar 13;363(9412):892-4. PMID: 15031036
Study Type : Review
[+]
Pubmed Data : JAMA. 2003 Apr 2 ;289(13):1681-90. PMID: 12672737
Study Type : Review
Additional Links
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : J Atheroscler Thromb. 2009;16(6):870-7. Epub 2009 Dec 22. PMID: 20032581
Study Type : In Vitro Study
Additional Links
Diseases : Myopathies
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Muscle Nerve. 2010 Feb ;41(2):179-84. PMID: 19813190
Study Type : In Vitro Study
Additional Links
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Expert Opin Drug Saf. 2011 Feb 23. Epub 2011 Feb 23. PMID: 21342078
Study Type : Review
Additional Links
Diseases : Myopathies
Problem Substances : Atorvastatin, Rosuvastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Biochem Pharmacol. 2010 Apr 15 ;79(8):1200-9. Epub 2009 Dec 14. PMID: 20018177
Study Type : In Vitro Study
Additional Links
Problem Substances : Simvastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Biochem Biophys Res Commun. 2005 Apr 15 ;329(3):1067-75. PMID: 15752763
Study Type : In Vitro Study
Additional Links
Problem Substances : Simvastatin
Adverse Pharmacological Actions : Myotoxicity
[+]
Study Type : Review
Additional Links
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Am J Med. 2006 May ;119(5):400-9. PMID: 16651050
Study Type : Review
Additional Links
Problem Substances : Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Angiology. 2011 Mar 18. Epub 2011 Mar 18. PMID: 21421631
Study Type : Review
Additional Links
Diseases : Myopathies
Problem Substances : Rosuvastatin
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Toxicol Appl Pharmacol. 1997 Jul ;145(1):99-110. PMID: 9221829
Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Anticholesteremic Agents
Problem Substances : Lovastatin, Pravastatin , Statin Drugs
Adverse Pharmacological Actions : Myotoxicity
[+]
Pubmed Data : Ann Univ Mariae Curie Sklodowska Med. 2004 ;59(2):32-7. PMID: 16146045
Study Type : In Vitro Study
Additional Links
Problem Substances : Atorvastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity, Neurotoxic
[+]
Pubmed Data : Expert Opin Drug Saf. 2002 Sep ;1(3):207-12. PMID: 12904136
Study Type : Review
Additional Links
Diseases : Rhabdomyolysis
Problem Substances : Cerivastatin, Statin Drugs
Adverse Pharmacological Actions : Myotoxicity

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