Acetaminophen (Tylenol) Toxicity

View the Evidence:
92 Abstracts with Acetaminophen (Tylenol) Toxicity Research

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Pubmed Data : Transfus Med Rev. 2007 Jan;21(1):1-12. PMID: 17174216
Study Type : Human Study
Additional Links
Problem Substances : Diphenhydramine, Tylenol
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Pubmed Data : Autism. 2008 May;12(3):293-307. PMID: 18445737
Study Type : Human Study
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : JAMA Pediatr. 2016 Oct 1 ;170(10):964-970. PMID: 27533796
Study Type : Human Study
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Pubmed Data : Altern Med Rev. 2009 Dec;14(4):364-72. PMID: 20030462
Study Type : Human Study
Additional Links
Additional Keywords : Diseases that are Linked
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Pubmed Data : J Clin Oncol. 2011 May 9. Epub 2011 May 9. PMID: 21555699
Study Type : Human Study
Additional Links
Problem Substances : Tylenol
Adverse Pharmacological Actions : Carcinogenic
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Pubmed Data : Z Gastroenterol. 2009 Sep;47(9):807-13. Epub 2009 Sep 11. PMID: 19750427
Study Type : Human Study
Additional Links
Problem Substances : Tylenol
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Pubmed Data : Int J Epidemiol. 2016 Dec 1 ;45(6):1998-2008. PMID: 27585674
Study Type : Human Study
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Pubmed Data : Epidemiology. 2016 Nov ;27(6):912-8. PMID: 27479646
Study Type : Human Study
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Pubmed Data : Int J Epidemiol. 2016 Dec 1 ;45(6):2009-2017. PMID: 28031314
Study Type : Human Study
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Pubmed Data : Hum Reprod. 2017 Jan ;32(1):223-231. Epub 2016 Nov 16. PMID: 27852690
Study Type : Human Study
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Clin Psychiatry. 2016 Mar ;77(3):e312-4. PMID: 27046315
Study Type : Human Study
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Pubmed Data : Dig Dis Sci. 1988 Jun;33(6):641-8. PMID: 3371135
Study Type : Human Study
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Pubmed Data : Int J Mol Med. 2015 Jun 19. Epub 2015 Jun 19. PMID: 26096646
Study Type : Human In Vitro
Additional Links
Additional Keywords : Mesenchymal Stem Cells
Problem Substances : Acetaminophen, Paracetamol
Adverse Pharmacological Actions : Cytotoxic
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Pubmed Data : Drug Dev Res. 2015 Aug ;76(5):251-8. Epub 2015 Aug 7. PMID: 26250417
Study Type : Animal Study
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Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
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Pubmed Data : Zhong Xi Yi Jie He Xue Bao. 2011 Nov ;9(11):1264-9. PMID: 22088594
Study Type : Animal Study
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Substances : Gingerol
Pharmacological Actions : Hepatoprotective
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : J Pak Med Assoc. 2016 Jul ;66(7):859-63. PMID: 27427136
Study Type : Animal Study
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Substances : Pomegranate Peel
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Plant Extracts
Problem Substances : Acetaminophen, Paracetamol
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Pubmed Data : Toxicology. 2007 Jan 5;229(1-2):62-72. Epub 2006 Oct 17. PMID: 17126469
Study Type : Animal Study
Additional Links
Additional Keywords : Toxic Substance Synergy
Problem Substances : Tylenol, Uranium
Adverse Pharmacological Actions : Hepatotoxic, Nephrotoxic
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Pubmed Data : Toxicol Sci. 2015 Dec 31. Epub 2015 Dec 31. PMID: 26721299
Study Type : Animal Study
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Pubmed Data : Toxicology. 2008 Jan 20;243(3):261-70. Epub 2007 Oct 23. PMID: 18068886
Study Type : Animal Study
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Substances : Alpha-Lipoic Acid
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2014 ;19(10):15440-51. Epub 2014 Sep 26. PMID: 25264831
Study Type : Animal Study
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Pubmed Data : J R Soc Med. 2010 Oct;103(10):403-11. PMID: 20929891
Study Type : Animal Study
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Pubmed Data : Eur J Drug Metab Pharmacokinet. 2017 Mar 2. Epub 2017 Mar 2. PMID: 28255865
Study Type : Animal Study
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Substances : Apigenin
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
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Pubmed Data : J Intercult Ethnopharmacol. 2016 Jan-Feb;5(1):27-35. Epub 2016 Jan 27. PMID: 27069723
Study Type : Animal Study
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Substances : Papaya
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Plant Extracts
Problem Substances : Acetaminophen, Paracetamol
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Pubmed Data : J Environ Pathol Toxicol Oncol. 2012 ;31(3):193-201. PMID: 23339694
Study Type : Animal Study
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Substances : Rose
Pharmacological Actions : Antioxidants
Additional Keywords : Phytotherapy, Plant Extracts
Problem Substances : Acetaminophen, Paracetamol
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Curr Ther Res Clin Exp. 2015 Dec ;77:73-8. Epub 2015 May 27. PMID: 26543508
Study Type : Animal Study
Additional Links
Substances : Burdock
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
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Pubmed Data : Arch Biochem Biophys. 2016 Jun 7. Epub 2016 Jun 7. PMID: 27288086
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
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Pubmed Data : Int Immunopharmacol. 2017 Jan 30 ;45:26-33. Epub 2017 Jan 30. PMID: 28152447
Study Type : Animal Study
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Mediators Inflamm. 2014 ;2014:196598. Epub 2014 Nov 12. PMID: 25435714
Study Type : Animal Study
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Substances : Baccharis trimera
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Plant Extracts
Problem Substances : Acetaminophen, Paracetamol
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Pubmed Data : Curr Pharm Biotechnol. 2013 ;14(11):975-84. PMID: 24372242
Study Type : Animal Study
Additional Links
Substances : Baccharis trimera
Pharmacological Actions : Antioxidants
Problem Substances : Acetaminophen, Paracetamol
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Pubmed Data : Fitoterapia. 2000 Feb ;71(1):25-33. PMID: 11449466
Study Type : Animal Study
Additional Links
Substances : Berberine
Pharmacological Actions : Hepatoprotective
Problem Substances : Paracetamol
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Pubmed Data : Pak J Pharm Sci. 2015 May ;28(3):951-7. PMID: 26004728
Study Type : Animal Study
Additional Links
Substances : Bitter Apple
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Phytotherapy, Plant Extracts
Problem Substances : Paracetamol
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2017 Apr 21 ;22(4). Epub 2017 Apr 21. PMID: 28430162
Study Type : Animal Study
Additional Links
Additional Keywords : Phytotherapy
Problem Substances : Acetaminophen, Paracetamol
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : World J Gastroenterol. 2015 Sep 21 ;21(35):10091-103. PMID: 26401074
Study Type : Animal Study
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Pubmed Data : Korean J Physiol Pharmacol. 2016 Jan ;20(1):15-23. Epub 2015 Dec 31. PMID: 26807019
Study Type : Animal Study
Additional Links
Substances : Carnosic Acid
Problem Substances : Acetaminophen, Paracetamol
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Pubmed Data : J Food Sci. 2009 Oct;74(8):H259-65. PMID: 19799668
Study Type : Animal Study
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Pubmed Data : Andrologia. 2016 Feb 24. Epub 2016 Feb 24. PMID: 26914515
Study Type : Animal Study
Additional Links
Substances : Chrysin
Pharmacological Actions : Cytoprotective
Additional Keywords : Dose Response
Problem Substances : Acetaminophen, Paracetamol
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Sci Rep. 2016 Jan 27 ;6:19789. Epub 2016 Jan 27. PMID: 26813099
Study Type : Animal Study
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Pubmed Data : Food Chem Toxicol. 2009 Jul;47(7):1480-4. Epub 2009 Apr 2. PMID: 19345714
Study Type : Animal Study
Additional Links
Substances : Curcumin
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Pubmed Data : J Pharm Pharmacol. 2016 Jan 15. Epub 2016 Jan 15. PMID: 26773315
Study Type : Animal Study
Additional Links
Substances : Curcumin
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
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Pubmed Data : Curr Neurovasc Res. 2012 Jan 16. Epub 2012 Jan 16. PMID: 22272768
Study Type : Animal Study
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Pubmed Data : Eur J Pharmacol. 2010 Feb 25;628(1-3):274-81. Epub 2009 Nov 15. PMID: 19919835
Study Type : Animal Study
Additional Links
Pharmacological Actions : Hepatoprotective, Renoprotective
Additional Keywords : Drug Synergy
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Pubmed Data : Environ Toxicol Pharmacol. 2015 Sep ;40(2):369-74. Epub 2015 Jul 4. PMID: 26233562
Study Type : Animal Study
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Pubmed Data : Behav Brain Res. 2017 Apr 14 ;323:162-171. Epub 2017 Feb 3. PMID: 28163096
Study Type : Animal Study
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacogn Mag. 2017 Jan-Mar;13(49):108-113. PMID: 28216892
Study Type : Animal Study
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Substances : Juniper
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
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Pubmed Data : J Pharm Pharmacol. 2015 Apr ;67(4):565-72. Epub 2014 Dec 10. PMID: 25495794
Study Type : Animal Study
Additional Links
Substances : Panax Ginseng
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
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Pubmed Data : Food Chem Toxicol. 2007 Nov;45(11):2267-72. Epub 2007 Jun 9. PMID: 17637489
Study Type : Animal Study
Additional Links
Substances : Ginger
Pharmacological Actions : Hepatoprotective
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Pubmed Data : J Agric Food Chem. 2017 May 10 ;65(18):3684-3692. Epub 2017 Apr 25. PMID: 28429935
Study Type : Animal Study
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Pubmed Data : Exp Toxicol Pathol. 2017 Jan 30. Epub 2017 Jan 30. PMID: 28153389
Study Type : Animal Study
Additional Links
Pharmacological Actions : Hepatoprotective, Renoprotective
Problem Substances : Acetaminophen, Paracetamol
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Pharmacognosy Res. 2011 Oct ;3(4):250-5. PMID: 22224048
Study Type : Animal Study
Additional Links
Substances : Goldenseal
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
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Pubmed Data : Arch Biochem Biophys. 1999 Sep 1;369(1):42-58. PMID: 10462439
Study Type : Animal Study
Additional Links
Substances : Grape Seed Extract
Pharmacological Actions : Anti-Apoptotic, Antioxidants
Additional Keywords : Proanthocyanidins
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Pubmed Data : Toxicol Sci. 2016 Mar ;150(1):178-89. Epub 2016 Jan 5. PMID: 26732887
Study Type : Animal Study
Additional Links
Additional Keywords : Risk Factors
Problem Substances : Acetaminophen, Paracetamol
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Pubmed Data : Life Sci. 2016 May 1 ;152:180-9. Epub 2016 Apr 3. PMID: 27049115
Study Type : Animal Study
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Pubmed Data : Int Immunopharmacol. 2015 Jul ;27(1):164-70. Epub 2015 May 19. PMID: 26002582
Study Type : Animal Study
Additional Links
Substances : Luteolin
Problem Substances : Acetaminophen
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Pubmed Data : Chem Biol Interact. 2017 Feb 1 ;263:7-17. Epub 2016 Dec 15. PMID: 27989599
Study Type : Animal Study, In Vitro Study
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Pubmed Data : Bioorg Med Chem. 2017 Feb 1 ;25(3):1057-1065. Epub 2016 Dec 18. PMID: 28031152
Study Type : Animal Study
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Pubmed Data : Int Urol Nephrol. 2009;41(3):695-702. Epub 2009 Jan 1. PMID: 19117117
Study Type : Animal Study
Additional Links
Substances : Melatonin
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PeerJ. 2016 ;4:e2127. Epub 2016 Jul 7. PMID: 27441110
Study Type : Animal Study
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Pubmed Data : Food Chem Toxicol. 2008 Aug;46(8):2611-5. Epub 2008 Apr 25. PMID: 18514995
Study Type : Animal Study
Additional Links
Substances : Moringa oleifera
Pharmacological Actions : Glutathione Upregulation
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Pubmed Data : Ren Fail. 2016 Apr 6:1-14. Epub 2016 Apr 6. PMID: 27050864
Study Type : Animal Study
Additional Links
Substances : Citrus naringin
Problem Substances : Paracetamol
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Pubmed Data : Pak J Biol Sci. 2014 Apr ;17(4):517-22. PMID: 25911839
Study Type : Animal Study
Additional Links
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Phytotherapy, Plant Extracts
Problem Substances : Paracetamol
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Pubmed Data : Pharm Biol. 2016 Mar 9:1-10. Epub 2016 Mar 9. PMID: 26956915
Study Type : Animal Study
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Asian Pac J Trop Med. 2016 Mar ;9(3):221-7. Epub 2016 Jan 13. PMID: 26972391
Study Type : Animal Study, In Vitro Study
Additional Links
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
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Pubmed Data : Pharm Biol. 2017 Dec ;55(1):1809-1816. PMID: 28545313
Study Type : Animal Study
Additional Links
Substances : Rosemaric Acid
Pharmacological Actions : Hepatoprotective
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Evid Based Complement Alternat Med. 2015 ;2015:347861. Epub 2015 Aug 2. PMID: 26300946
Study Type : Animal Study
Additional Links
Substances : Plantago major
Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
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Pubmed Data : Phytomedicine. 2009 Aug;16(8):751-60. Epub 2009 Apr 21. PMID: 19386480
Study Type : Animal Study
Additional Links
Pharmacological Actions : Hepatoprotective
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2017 Aug 25 ;22(9). Epub 2017 Aug 25. PMID: 28841174
Study Type : Animal Study
Additional Links
Substances : Dandelion
Pharmacological Actions : Antioxidants, Hepatoprotective, Nrf2 activation
Additional Keywords : Polysaccharides
Problem Substances : Acetaminophen, Paracetamol
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Turk Pediatri Ars. 2016 Jun ;51(2):72-8. Epub 2016 Jun 1. PMID: 27489463
Study Type : Animal Study
Additional Links
Substances : Pomegranate
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
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Pubmed Data : Pharmacol Rep. 2016 Dec ;68(6):1159-1164. Epub 2016 Sep 7. PMID: 27611980
Study Type : Animal Study
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Reproduction. 2017 Aug ;154(2):145-152. Epub 2017 May 30. PMID: 28559473
Study Type : Animal Study
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Pubmed Data : Arch Pharm Res. 2012 Jun ;35(6):1099-105. Epub 2012 Jun 30. PMID: 22870820
Study Type : Animal Study
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Pubmed Data : Sci Transl Med. 2015 May 20 ;7(288):288ra80. PMID: 25995226
Study Type : Animal Study
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Pubmed Data : Phytother Res. 2006 Sep ;20(9):780-3. PMID: 16807884
Study Type : Animal Study
Additional Links
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Plant Extracts
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Pubmed Data : Food Chem Toxicol. 2010 Nov;48(11):3246-61. Epub 2010 Sep 4. PMID: 20804811
Study Type : Animal Study
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Nutrients. 2016 ;8(7). Epub 2016 Jul 15. PMID: 27428996
Study Type : Animal Study, In Vitro Study
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Pubmed Data : Shock. 2009 Jul ;32(1):89-93. PMID: 18948843
Study Type : Animal Study
Additional Links
Substances : Sesamol
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Tylenol
Adverse Pharmacological Actions : Hepatotoxic, Oxidant
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Pubmed Data : Molecules. 2010 Jun;15(6):4478-89. Epub 2010 Jun 23. PMID: 20657455
Study Type : Animal Study
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Pubmed Data : Food Chem Toxicol. 2015 Jun ;80:193-200. Epub 2015 Mar 25. PMID: 25818464
Study Type : Animal Study, In Vitro Study
Additional Links
Substances : Sulforaphane
Pharmacological Actions : Antioxidants, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
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Pubmed Data : Drug Chem Toxicol. 2015 Aug 3:1-9. Epub 2015 Aug 3. PMID: 26234406
Study Type : Animal Study
Additional Links
Substances : Black Tea
Pharmacological Actions : Antioxidants, Hepatoprotective, Renoprotective
Additional Keywords : Dose Response
Problem Substances : Acetaminophen, Paracetamol
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Biomedicine (Taipei). 2015 Sep ;5(3):15. Epub 2015 Aug 12. PMID: 26264479
Study Type : Animal Study
Additional Links
Pharmacological Actions : Hepatoprotective
Problem Substances : Acetaminophen
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Pubmed Data : J Basic Clin Physiol Pharmacol. 2017 Aug 3. Epub 2017 Aug 3. PMID: 28771433
Study Type : Animal Study
Additional Links
Substances : Vitamin C
Problem Substances : Acetaminophen, Paracetamol
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Pubmed Data : Am J Pathol. 2015 Oct ;185(10):2805-18. Epub 2015 Aug 5. PMID: 26254283
Study Type : Animal Study
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Molecules. 2017 May 18 ;22(5). Epub 2017 May 18. PMID: 28524081
Study Type : Animal Study
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Pubmed Data : In Vitro Cell Dev Biol Anim. 2011 Dec ;47(10):698-706. PMID: 21975853
Study Type : Animal Study
Additional Links
Substances : Tribulus
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Plant Extracts
Problem Substances : Tylenol
Adverse Pharmacological Actions : Hepatotoxic
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Pubmed Data : Chem Biol Interact. 2010 Mar 19;184(1-2):58-66. Epub 2010 Jan 6. PMID: 20020268
Study Type : Review
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Acta Neurobiol Exp (Wars). 2010;70(2):227-31. PMID: 20628445
Study Type : Review
Additional Links
Additional Keywords : Diseases that are Linked
Problem Substances : Tylenol
Adverse Pharmacological Actions : Neurotoxic
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Pubmed Data : Biochem Pharmacol. 1990 Jun 15;39(12):1869-75. PMID: 2353930
Study Type : In Vitro Study
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : PLoS One. 2015 ;10(12):e0145965. Epub 2015 Dec 29. PMID: 26714183
Study Type : In Vitro Study
Additional Links
Substances : Diallyl sulfide
Pharmacological Actions : Chemopreventive, Hepatoprotective
Problem Substances : Acetaminophen, Paracetamol
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Am J Transl Res. 2015 ;7(2):309-18. Epub 2015 Feb 15. PMID: 25901199
Study Type : In Vitro Study
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Pubmed Data : Curr Opin Allergy Clin Immunol. 2017 Apr ;17(2):110-115. PMID: 28079560
Study Type : Review
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Pubmed Data : Liver Int. 2010 Sep;30(8):1103-14. Epub 2010 Jun 14. PMID: 20557453
Study Type : Review
Additional Links
Substances : Resveratrol
Additional Keywords : Stilbenes
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Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : Daru. 2015 ;23(1):31. Epub 2015 May 1. PMID: 25928729
Study Type : Review
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Pubmed Data : Hum Exp Toxicol. 2016 Jan 22. Epub 2016 Jan 22. PMID: 26801986
Study Type : In Vitro Study
Additional Links
Substances : Carvacrol, Thymol
Pharmacological Actions : Antioxidants, Hepatoprotective
Additional Keywords : Dose Response
Problem Substances : Acetaminophen, Paracetamol

Acetaminophen (Tylenol) Toxicity Related Articles

Written by Sarah Couture Pope
The vast majority of babies are given Tylenol (acetaminophen) within the first six months of life. A major study of suggests even only occasional use can have life-threatening health effects.
Written by Kelly Brogan, M.D.
You know Tylenol can relieve a headache, but are you aware it can cause other side effects, such as increased risk of death or heart toxicity?
Written by Sayer Ji, Founder
For decades Tylenol has been used as a pain-killer, but new research reveals it has psychiatric side effects including dulled emotional responses to both positive and negative stimuli.
Written by Sayer Ji, Founder
Aspirin's long held promises are increasingly falling flat. A natural, safer and more effective alternative to this synthetic drug has been known about for at least 15 years!
Should you trust safety reports on acetaminophen? If you're pregnant, the answer may surprise you.
Written by Dr. Michael Murray
Most people consider acetaminophen (e.g., Tylenol) as being an extremely safe pain reliever for both children and adults. The reality is that it can be extremely dangerous and causes significant side effects.

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