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Advanced Glycation End products (AGE)

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Article Count - 40
Cumulative Knowledge - 104

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Quick Summary: Current access displays 2 out of 39 associated Substances

Name	Cumulative Knowledge	Article Count	Focus Articles
Benfotiamine	20	2	Log in \| Sign up
DHEA (Dehydroepiandrosterone)	20	2	Log in \| Sign up

Quick Summary: 1 associated Problem Substances

Name	Cumulative Knowledge	Article Count	Focus Articles
Fructose	4	2	Log in \| Sign up

Quick Summary: 1 associated Therapeutic Actions

Name	Cumulative Knowledge	Article Count	Focus Articles
Tai Chi	10	1	Log in \| Sign up

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View the Evidence: Ailments

A topical product containing C-xyloside and blueberry extract improves the appearance of type II diabetic skin.

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Pubmed Data : J Cosmet Dermatol. 2009 Jun;8(2):147-51. PMID: 19527341

Article Published Date : Jun 01, 2009

Study Type : Human Study

Additional Links

Substances : Blueberry : CK(140) : AC(39), X-xyloside : CK(10) : AC(1)

Diseases : Advanced Glycation End products (AGE) : CK(2114) : AC(40), Aging Skin : CK(360) : AC(86), Diabetes: Skin : CK(10) : AC(1), Diabetes Mellitus: Type 2 : CK(3429) : AC(341)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Benfotiamine inhibits oxidative stress with type 2 diabetes.

Click here to read the entire abstract

Pubmed Data : Diabetes Care. 2006 Sep;29(9):2064-71. PMID: 16936154

Article Published Date : Sep 01, 2006

Study Type : Human Study

Additional Links

Substances : Benfotiamine : CK(66) : AC(10)

Diseases : Advanced Glycation End products (AGE) : CK(2114) : AC(40), Diabetes: Glycation/A1C : CK(186) : AC(33), Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Oxidative Stress : CK(1945) : AC(710)

Additional Keywords : Advanced Glycation End Products : CK(10) : AC(1)

DHEA administration counteracts oxidative imbalance and advanced glycation end product formation in type 2 diabetic patients.

Click here to read the entire abstract

Pubmed Data : Phytother Res. 2009 Mar;23(3):303-7. PMID: 17704347

Article Published Date : Mar 01, 2009

Study Type : Human Study

Additional Links

Substances : DHEA (Dehydroepiandrosterone) : CK(230) : AC(37)

Diseases : Advanced Glycation End products (AGE) : CK(2114) : AC(40), Diabetes Mellitus: Type 2 : CK(3429) : AC(341)

Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

Tai Chi exercise stimulates endogenous antioxidant enzymes and reduces oxidaitve damage.

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Pubmed Data : J Phys Act Health. 2009 Jan;6(1):43-54. PMID: 19211957

Article Published Date : Jan 01, 2009

Study Type : Human Study

Additional Links

Diseases : Advanced Glycation End products (AGE) : CK(2114) : AC(40), DNA damage : CK(711) : AC(293), Oxidative Stress : CK(1945) : AC(710)

Therapeutic Actions : Tai Chi : CK(382) : AC(38)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)

The intake of 2g of cinnamon for 12 weeks significantly reduces the HbA1c, systolic and diastolic blood pressures among poorly controlled type 2 diabetes patients.

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Pubmed Data : Photochem Photobiol. 2004 Nov-Dec;80(3):579-82. PMID: 20854384

Article Published Date : Nov 01, 2004

Study Type : Human Study

Additional Links

Substances : Cinnamon : CK(135) : AC(61)

Diseases : Advanced Glycation End products (AGE) : CK(2114) : AC(40), Diabetes: Cardiovascular Illness : CK(666) : AC(104), Diabetes: Glycation/A1C : CK(186) : AC(33), Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Hypertension : CK(2783) : AC(271)

Vitamin B(6) supplementation might be successful in preventing advanced glycation endproducts-related pathologies.

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Pubmed Data : Nephron Clin Pract. 2010;114(1):c38-c46. Epub 2009 Oct 9. PMID: 19816042

Article Published Date : Jan 01, 2010

Study Type : Human Study

Additional Links

Substances : Vitamin B-6 : CK(412) : AC(48)

Diseases : Advanced Glycation End products (AGE) : CK(2114) : AC(40)

Apple leaves contain compounds which may have therapeutic value against advanced glycation end-productions and vasoconstriction.

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Pubmed Data : Phytochemistry. 2009 Dec 18. Epub 2009 Dec 18. PMID: 20022617

Article Published Date : Dec 18, 2009

Study Type : Animal Study

Additional Links

Substances : Apples : CK(179) : AC(57)

Diseases : Advanced Glycation End products (AGE) : CK(2114) : AC(40)

Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Vasodilator Agents : CK(262) : AC(54)

Astragalosides isolated from astragalus roots inhibit the formation of advanced glycation end products.

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Pubmed Data : J Agric Food Chem. 2009 Sep 9;57(17):7666-72. PMID: 19681610

Article Published Date : Sep 09, 2009

Study Type : Animal Study

Additional Links

Substances : Arginine : CK(970) : AC(169)

Diseases : Advanced Glycation End products (AGE) : CK(2114) : AC(40)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Cinnamon bark proanthocyanidins prevent the formation of advanced glycation endproducts.

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Pubmed Data : J Psychiatry Neurosci. 2001 May;26(3):221-8. PMID: 18284204

Article Published Date : May 01, 2001

Study Type : Animal Study

Additional Links

Substances : Cinnamon : CK(135) : AC(61)

Diseases : Advanced Glycation End products (AGE) : CK(2114) : AC(40), Diabetes: Glycation/A1C : CK(186) : AC(33)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)

Cumin has blood sugar lowering and anti-glycation properties supeior to the drug glibenclamide.

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Pubmed Data : Food Chem Toxicol. 2010 Aug-Sep;48(8-9):2030-6. Epub 2010 May 6. PMID: 20451573

Article Published Date : Aug 01, 2010

Study Type : Animal Study

Additional Links

Substances : Cumin : CK(32) : AC(21)

Diseases : Advanced Glycation End products (AGE) : CK(2114) : AC(40), Diabetes: Gestational : CK(12) : AC(2), Diabetes: Oxidative Stress : CK(65) : AC(18), Diabetes Mellitus: Type 2 : CK(3429) : AC(341)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318), Hypoglycemic Agents : CK(563) : AC(156)

Additional Keywords : Drug: Glibenclamide : CK(12) : AC(2), Natural Substances Versus Drugs : CK(988) : AC(165), Plant Extracts : CK(3572) : AC(1216)

Curcumin prevents advanced glycation induced complications of diabetes.

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Pubmed Data : Biochem Pharmacol. 1998 Dec 15;56(12):1607-14. PMID: 9973181

Article Published Date : Dec 15, 1998

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2910) : AC(1482)

Diseases : A1C : CK(253) : AC(35), Advanced Glycation End products (AGE) : CK(2114) : AC(40), Diabetic Complications : CK(1261) : AC(221), Oxidative Stress : CK(1945) : AC(710)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)

Cyperus rotundus suppresses AGE formation and protein oxidation in a model of fructose-mediated protein glycoxidation.

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Pubmed Data : Int J Biol Macromol. 2007 Dec 1;41(5):572-8. Epub 2007 Jul 27. PMID: 17765965

Article Published Date : Dec 01, 2007

Study Type : Animal Study

Additional Links

Substances : Cyperus rotundus : CK(7) : AC(4), Flavonoids : CK(909) : AC(289), Polyphenols : CK(427) : AC(174)

Diseases : Advanced Glycation End products (AGE) : CK(2114) : AC(40), Fructose-Induced Toxicity : CK(138) : AC(49)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Fructose contributes to protein cross-linking.

Click here to read the entire abstract

Pubmed Data : Biochemistry. 1988 Mar 22;27(6):1901-7. PMID: 3132203

Article Published Date : Mar 22, 1988

Study Type : Animal Study

Additional Links

Diseases : Advanced Glycation End products (AGE) : CK(2114) : AC(40), Diabetes: Glycation/A1C : CK(186) : AC(33), Glycation : CK(3) : AC(2)

Problem Substances : Fructose : CK(356) : AC(103)

Adverse Pharmacological Actions : Oxidant : CK(104) : AC(37)

Fructose-fed rats exhibit increased inflammation, fibrogenesis and NF-κB activation.

Click here to read the entire abstract

Pubmed Data : Eur J Pharmacol. 2011 Jun 17. Epub 2011 Jun 17. PMID: 21704028

Article Published Date : Jun 17, 2011

Study Type : Animal Study

Additional Links

Diseases : Advanced Glycation End products (AGE) : CK(2114) : AC(40), Inflammation : CK(1077) : AC(363), Kidney Damage : CK(120) : AC(42), Kidney Diseases : CK(424) : AC(71), Kidney Fibrosis : CK(10) : AC(5)

Problem Substances : Fructose : CK(356) : AC(103)

Adverse Pharmacological Actions : Inflammatory : CK(150) : AC(37), Nephrotoxic : CK(162) : AC(38), NF-kappaB up-regulation : CK(3) : AC(2), Oxidant : CK(104) : AC(37), Profibrotic : CK(4) : AC(2)

Grape seed proanthocyanidin inhibit advanced glycation end products in diabetic rats.

Click here to read the entire abstract

Pubmed Data : Biosci Biotechnol Biochem. 2009 Jun;73(6):1348-54. Epub 2009 Jun 7. PMID: 19502731

Article Published Date : Jun 01, 2009

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract : CK(168) : AC(57)

Diseases : Advanced Glycation End products (AGE) : CK(2114) : AC(40), Diabetes: Cardiovascular Illness : CK(666) : AC(104)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216), Proanthocyanidins : CK(159) : AC(46)

Grapeseed extract ameliorates glycation-induced cardiac damage.

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Pubmed Data : J Cardiovasc Pharmacol. 2007 Nov;50(5):503-9. PMID: 18030059

Article Published Date : Nov 01, 2007

Study Type : Animal Study

Additional Links

Substances : Grape Seed Extract : CK(168) : AC(57)

Diseases : Advanced Glycation End products (AGE) : CK(2114) : AC(40), Cardiomyopathy : CK(77) : AC(15)

Heat-processed American Ginseng extract inhibits the formation of Advanced Glycation Endproducts (AGEs) via a hypoglycemic effect, ameloriating diabetic nephropathy.

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Pubmed Data : J Agric Food Chem. 2007 Oct 17;55(21):8491-7. Epub 2007 Sep 26. PMID: 17894462

Article Published Date : Oct 17, 2007

Study Type : Animal Study

Additional Links

Substances : Ginseng (American) : CK(121) : AC(31)

Diseases : Advanced Glycation End products (AGE) : CK(2114) : AC(40), Diabetes: Kidney Function : CK(75) : AC(22), Diabetic Nephropathy : CK(43) : AC(17)

Matcha, a powdered green tea, ameliorates the progression of renal and hepatic damage in type 2 diabetic rats.

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Pubmed Data : J Med Food. 2009 Aug;12(4):714-21. PMID: 19735169

Article Published Date : Aug 01, 2009

Study Type : Animal Study

Additional Links

Substances : Green Tea : CK(930) : AC(294)

Diseases : Advanced Glycation End products (AGE) : CK(2114) : AC(40), Diabetes Mellitus: Type 2 : CK(3429) : AC(341), Diabetic Nephropathy : CK(43) : AC(17)

Additional Keywords : Plant Extracts : CK(3572) : AC(1216)

Mustard Greens (B. juncea) protect against oxidative stress in diabetic rats. - Article 1

Click here to read the entire abstract

Pubmed Data : J Nutr Sci Vitaminol (Tokyo). 2003 Apr;49(2):87-93. PMID: 12887153

Article Published Date : Apr 01, 2003

Study Type : Animal Study

Additional Links

Substances : Mustard Greens : CK(39) : AC(12)

Diseases : Advanced Glycation End products (AGE) : CK(2114) : AC(40), Diabetes: Oxidative Stress : CK(65) : AC(18), Diabetes Mellitus: Type 1 : CK(1107) : AC(218)

Puerarin suppresses advanced glycation end product-induced inflammation in mouse mesangial cells

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Pubmed Data : Toxicol Appl Pharmacol. 2010 Jan 6. Epub 2010 Jan 6. PMID: 20060010

Article Published Date : Jan 06, 2010

Study Type : Animal Study

Additional Links

Substances : Puerarin : CK(14) : AC(7)

Diseases : Advanced Glycation End products (AGE) : CK(2114) : AC(40)

Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433)

Resveratrol ameliorates vasculopathy in diabetic rats.

Click here to read the entire abstract

Pubmed Data : Diabetes Metab Res Rev. 2010 Mar;26(3):212-22. PMID: 20474069

Article Published Date : Mar 01, 2010

Study Type : Animal Study

Additional Links

Substances : Resveratrol : CK(977) : AC(590)

Diseases : Advanced Glycation End products (AGE) : CK(2114) : AC(40), Diabetes: Cardiovascular Illness : CK(666) : AC(104), Diaetes: Vascular Dysfunction : CK(2) : AC(1)

Pharmacological Actions : Cardioprotective : CK(702) : AC(196), NF-kappaB Inhibitor : CK(595) : AC(401), Vasoprotective : CK(21) : AC(9)

Additional Keywords : Stilbenes : CK(402) : AC(242)

Salidroside, a compound found within rhodiola, protects against aging in a mouse model.

Click here to read the entire abstract

Pubmed Data : Biomed Environ Sci. 2010 Apr;23(2):161-6. PMID: 20514993

Article Published Date : Apr 01, 2010

Study Type : Animal Study

Additional Links

Substances : Rhodiola (Tibetan Ginseng) : CK(119) : AC(28)

Diseases : Advanced Glycation End products (AGE) : CK(2114) : AC(40), Aging : CK(1351) : AC(369)

Acerola contains polyphenols with free radical scavenging activity and which inhibit the formation of advanced glycation end product (AGE) formation.

Click here to read the entire abstract

Pubmed Data : Biosci Biotechnol Biochem. 2005 Feb;69(2):280-6. PMID: 15725651

Article Published Date : Feb 01, 2005

Study Type : In Vitro Study

Additional Links

Substances : Acerola : CK(10) : AC(7)

Diseases : Advanced Glycation End products (AGE) : CK(2114) : AC(40)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)

Astaxanthin inhibits processes associated with diabetic retinopathy.

Click here to read the entire abstract

Pubmed Data : Food Funct. 2011 May 25 ;2(5):251-8. Epub 2011 Apr 21. PMID: 21779563

Article Published Date : May 25, 2011

Study Type : In Vitro Study

Additional Links

Substances : Astaxanthin : CK(353) : AC(117)

Diseases : Advanced Glycation End products (AGE) : CK(2114) : AC(40), Diabetic Retinopathy : CK(23) : AC(10)

Berberine ameloriates diabetic microendothelial injury associated with high blood sugar and glycation.

Click here to read the entire abstract

Pubmed Data : Eur J Pharmacol. 2011 Jan 13. Epub 2011 Jan 13. PMID: 21236251

Article Published Date : Jan 13, 2011

Study Type : In Vitro Study

Additional Links

Substances : Berberine : CK(156) : AC(75)

Diseases : Advanced Glycation End products (AGE) : CK(2114) : AC(40), Diabetes: Glycation/A1C : CK(186) : AC(33), Diabetes Mellitus: Type 2 : CK(3429) : AC(341)

Pharmacological Actions : Antioxidants : CK(3653) : AC(1318)

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From Tomb To Table: Cumin's Health Benefit's Rediscovered

Written by Sayer Ji, Founder

This enchanting spice, found in Egyptian tombs and on Greek tables, alike, has been the subject of renewed scientific interest in the past few decades. It was recently tested to be superior to a popular antidiabetic drug in an experimental model of diabetes.

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