Aluminum Toxicity

Aluminum Toxicity

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What is Cumulative Knowledge?

Cumulative Knowledge is determined by ascribing a numerical value to the various study types weighted in descending order as follows: (1) Meta-Analysis; (2) Human Study; (3) Human: Case Study; (4) Animal: Transgenic; (5) Animal; (6) In Vitro; (7) Review; and (8) Commentary.

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Quick Summary: 20 associated Substances

Name	Cumulative Knowledge	Article Count	Focus Articles
Silica	10	1	Log in \| Sign up
Silica: Orthosilicic acid	10	1	Log in \| Sign up
Bee Propolis	8	4	Log in \| Sign up
Curcumin	6	3	Log in \| Sign up
NAC (N-acetyl-L-cysteine)	6	3	Log in \| Sign up
Vitamin E	6	3	Log in \| Sign up
Lithium	4	2	Log in \| Sign up
Vitamin C	4	2	Log in \| Sign up
Coconut Oil	3	1	Log in \| Sign up
Bacopa	2	1	Log in \| Sign up
Berberine	2	1	Log in \| Sign up
Citric Acid	2	1	Log in \| Sign up
Flavonoids	2	1	Log in \| Sign up
Folic Acid	2	1	Log in \| Sign up
Ginger	2	1	Log in \| Sign up
Ginkgo biloba	2	1	Log in \| Sign up
Goldenthread	2	1	Log in \| Sign up
Icariin	2	1	Log in \| Sign up
Selenium	2	1	Log in \| Sign up
Turmeric	2	1	Log in \| Sign up

Quick Summary: 7 associated Problem Substances

Name	Cumulative Knowledge	Article Count	Focus Articles
Aluminum	32	5	Log in \| Sign up
Antiperspirants	11	2	Log in \| Sign up
Parenteral Nutrition: Infant	10	1	Log in \| Sign up
Aluminum hydroxide	2	2	Log in \| Sign up
Vaccine Adjuvants	2	2	Log in \| Sign up
Aluminum Chloride	1	1	Log in \| Sign up
Infant Formula	1	1	Log in \| Sign up

Quick Summary: 1 associated Problematic Actions

Name	Cumulative Knowledge	Article Count	Focus Articles
Vaccination: All	2	2	Log in \| Sign up

View the Evidence: Ailments

Aluminium content is higher in nipple aspirate fluid of breast cancer-affected women versus healthy controls.

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Pubmed Data : J Appl Toxicol. 2011 Apr ;31(3):262-9. Epub 2011 Feb 21. PMID: 21337589

Article Published Date : Apr 01, 2011

Study Type : Human Study

Additional Links

Diseases : Aluminum Toxicity : CK(98) : AC(36), Breast Cancer : CK(2051) : AC(566), Heavy Metal Toxicity : CK(607) : AC(177)

Problem Substances : Aluminum : CK(130) : AC(31), Antiperspirants : CK(13) : AC(4)

Aluminium is found in human breast tissue and may be connected to breast cancer incidence.

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Pubmed Data : J Inorg Biochem. 2007 Sep ;101(9):1344-6. Epub 2007 Jun 12. PMID: 17629949

Article Published Date : Sep 01, 2007

Study Type : Human Study

Additional Links

Diseases : Aluminum Toxicity : CK(98) : AC(36), Breast Cancer : CK(2051) : AC(566)

Problem Substances : Aluminum : CK(130) : AC(31)

Adverse Pharmacological Actions : Endocrine Disruptor : CK(461) : AC(76)

Parenteral nutrition formulas for neonates have potentially toxic levels of aluminum.

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Pubmed Data : J Pediatr Gastroenterol Nutr. 2010 Feb;50(2):208-11. PMID: 20038851

Article Published Date : Feb 01, 2010

Study Type : Human Study

Additional Links

Diseases : Aluminum Toxicity : CK(98) : AC(36), Infant Chemical Exposures : CK(162) : AC(22), Premature Birth : CK(412) : AC(43)

Problem Substances : Aluminum : CK(130) : AC(31), Parenteral Nutrition: Infant : CK(10) : AC(1)

Silicic acid may reduce the body burden of aluminium in Alzheimer's patients.

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Pubmed Data : Am J Obstet Gynecol. 2006 Dec;195(6):1693-9. Epub 2006 Jun 21. PMID: 16988476

Article Published Date : Dec 01, 2006

Study Type : Human Study

Additional Links

Substances : Silica : CK(12) : AC(3), Silica: Orthosilicic acid : CK(40) : AC(4)

Diseases : Aluminum Toxicity : CK(98) : AC(36), Alzheimer's Disease : CK(837) : AC(165)

Pharmacological Actions : Detoxifier : CK(306) : AC(101)

Coconut oil may have therapeutic value in treating acute aluminium phosphide poisoning.

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Pubmed Data : Hum Exp Toxicol. 2005 Apr;24(4):215-8. PMID: 15957538

Article Published Date : Apr 01, 2005

Study Type : Human: Case Report

Additional Links

Substances : Coconut Oil : CK(75) : AC(18)

Diseases : Aluminum Toxicity : CK(98) : AC(36)

Aluminum toxicity is attenuated with vitamin E in rats.

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Pubmed Data : Int J Exp Pathol. 2003 Feb;84(1):49-54. PMID: 12694486

Article Published Date : Feb 01, 2003

Study Type : Animal Study

Additional Links

Substances : Vitamin E : CK(1290) : AC(218)

Diseases : Aluminum Toxicity : CK(98) : AC(36)

Bacopa prevents aluminium neurotoxicity in the rat brain.

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Pubmed Data : J Ethnopharmacol. 2007 Apr 20;111(1):56-62. Epub 2006 Nov 11. PMID: 17189676

Article Published Date : Apr 20, 2007

Study Type : Animal Study

Additional Links

Substances : Bacopa : CK(47) : AC(18)

Diseases : Aluminum Toxicity : CK(98) : AC(36)

Pharmacological Actions : Neuroprotective Agents : CK(921) : AC(464)

Berberine and coptis chinesis (goldenthread) extract prevents neurodegeneration induced by aluminum overload in rats.

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Pubmed Data : Saudi Med J. 2009 Jun;30(6):760-6. PMID: 19526156

Article Published Date : Jun 01, 2009

Study Type : Animal Study

Additional Links

Substances : Berberine : CK(144) : AC(70), Goldenthread : CK(7) : AC(5)

Diseases : Aluminum Toxicity : CK(98) : AC(36)

Citric acid prevents acute aluminum intoxication in a mouse model.

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Pubmed Data : Res Commun Chem Pathol Pharmacol. 1986 Jul;53(1):93-104. PMID: 3749610

Article Published Date : Jul 01, 1986

Study Type : Animal Study

Additional Links

Substances : Citric Acid : CK(12) : AC(2)

Diseases : Aluminum Toxicity : CK(98) : AC(36)

Curcumin attenuates aluminum-induced functional neurotoxicity in rats.

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Pubmed Data : Pharmacol Biochem Behav. 2009 Jul;93(1):31-9. Epub 2009 Apr 17. PMID: 19376155

Article Published Date : Jul 01, 2009

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2890) : AC(1511), Turmeric : CK(2969) : AC(1565)

Diseases : Aluminum Toxicity : CK(98) : AC(36)

Pharmacological Actions : Neuroprotective Agents : CK(921) : AC(464)

Curcumin counteracts the aluminium-induced ageing-related alterations in the rat brain.

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Pubmed Data : Biogerontology. 2009 Aug;10(4):489-502. Epub 2008 Nov 20. PMID: 19020987

Article Published Date : Aug 01, 2009

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2890) : AC(1511)

Diseases : Aging : CK(1341) : AC(369), Aging: Brain : CK(702) : AC(68), Aluminum Toxicity : CK(98) : AC(36), Oxidative Stress : CK(1867) : AC(710)

Pharmacological Actions : Antioxidants : CK(3503) : AC(1292), Neuroprotective Agents : CK(921) : AC(464)

Curcumin has a protective effect against aluminium toxicity in rats as measured by behavioral and biochemical alterations.

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Pubmed Data : Behav Brain Res. 2009 Jul 16. PMID: 19616038

Article Published Date : Jul 16, 2009

Study Type : Animal Study

Additional Links

Substances : Curcumin : CK(2890) : AC(1511)

Diseases : Aluminum Toxicity : CK(98) : AC(36)

Folic acid supplementation attenuate aluminum accumulation in rats.

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Pubmed Data : Nutrition. 2005 Mar;21(3):406-10. PMID: 15797685

Article Published Date : Mar 01, 2005

Study Type : Animal Study

Additional Links

Substances : Folic Acid : CK(572) : AC(77)

Diseases : Aluminum Toxicity : CK(98) : AC(36)

Ginger protects against reproductive toxicity of aluminium chloride in rats.

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Pubmed Data : Reprod Domest Anim. 2011 Jul 26. Epub 2011 Jul 26. PMID: 21790801

Article Published Date : Jul 26, 2011

Study Type : Animal Study

Additional Links

Substances : Ginger : CK(295) : AC(90)

Diseases : Aluminum Toxicity : CK(98) : AC(36)

Ginkgo biloba ameloriates aluminum-induced learning and memory deficits in rats.

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Pubmed Data : Chin J Integr Med. 2006 Mar;12(1):37-41. PMID: 16571282

Article Published Date : Mar 01, 2006

Study Type : Animal Study

Additional Links

Substances : Ginkgo biloba : CK(511) : AC(97)

Diseases : Aluminum Toxicity : CK(98) : AC(36), Memory Disorders : CK(211) : AC(65), Memory Loss : CK(113) : AC(32)

Pharmacological Actions : Acetylcholinesterase Inhibitor : CK(24) : AC(10)

Icariin protects against against learning and memory deficits induced by aluminium in rats.

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Pubmed Data : Clin Exp Pharmacol Physiol. 2007 Aug;34(8):792-5. PMID: 17600559

Article Published Date : Aug 01, 2007

Study Type : Animal Study

Additional Links

Substances : Flavonoids : CK(868) : AC(290), Icariin : CK(10) : AC(7)

Diseases : Aluminum Toxicity : CK(98) : AC(36), Learning disorders : CK(154) : AC(36), Oxidative Stress : CK(1867) : AC(710)

Pharmacological Actions : Antioxidants : CK(3503) : AC(1292)

Lithium has a protective effect against aluminium-induced oxidative stress and histological changes in rat brain.

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Pubmed Data : Cell Mol Neurobiol. 2009 Jun;29(4):513-21. Epub 2009 Jan 29. PMID: 19184412

Article Published Date : Jun 01, 2009

Study Type : Animal Study

Additional Links

Substances : Lithium : CK(31) : AC(8)

Diseases : Aluminum Toxicity : CK(98) : AC(36), Oxidative Stress : CK(1867) : AC(710)

Pharmacological Actions : Antioxidants : CK(3503) : AC(1292), Neuroprotective Agents : CK(921) : AC(464)

Lithium may reduce aluminium-induced cytotoxic effects in the rat brain.

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Pubmed Data : Biometals. 2010 Apr;23(2):197-206. PMID: 19936942

Article Published Date : Apr 01, 2010

Study Type : Animal Study

Additional Links

Substances : Lithium : CK(31) : AC(8)

Diseases : Aluminum Toxicity : CK(98) : AC(36), DNA damage : CK(680) : AC(293)

Pharmacological Actions : Antidepressive Agents : CK(122) : AC(28), Neuroprotective Agents : CK(921) : AC(464)

N-acetyl cysteine has a neuroprotective effect against aluminium-induced cognitive dysfunction and oxidative damage.

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Pubmed Data : Zhonghua Er Ke Za Zhi. 2003 Nov;41(11):822-6. PMID: 19389043

Article Published Date : Nov 01, 2003

Study Type : Animal Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine) : CK(258) : AC(62)

Diseases : Aluminum Toxicity : CK(98) : AC(36)

Pharmacological Actions : Neuroprotective Agents : CK(921) : AC(464)

N-acetyl cysteine reduces aluminium-induced myocardial oxidative injury.

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Pubmed Data : Acta Pharmacol Sin. 2001 Apr;22(4):298-304. PMID: 11742581

Article Published Date : Apr 01, 2001

Study Type : Animal Study

Additional Links

Substances : NAC (N-acetyl-L-cysteine) : CK(258) : AC(62)

Diseases : Aluminum Toxicity : CK(98) : AC(36)

Pharmacological Actions : Cardioprotective : CK(677) : AC(192)

Propolis alleviates aluminium induced lipid peroxidation and biochemical parameters in male rats.

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Pubmed Data : Food Chem Toxicol. 2009 Feb 2. Epub 2009 Feb 2. PMID: 19709589

Article Published Date : Feb 02, 2009

Study Type : Animal Study

Additional Links

Substances : Bee Propolis : CK(232) : AC(86)

Diseases : Aluminum Toxicity : CK(98) : AC(36)

Propolis alleviates aluminum-induced toxicity in rats.

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Pubmed Data : Food Chem Toxicol.2009 Jun;47(6):1093-8. PMID: 19425229

Article Published Date : Jun 01, 2009

Study Type : Animal Study

Additional Links

Substances : Bee Propolis : CK(232) : AC(86)

Diseases : Aluminum Toxicity : CK(98) : AC(36)

Propolis prevents aluminium-induced genetic and hepatic damages in rat liver.

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Pubmed Data : Evid Based Complement Alternat Med. 2008 Oct 9. PMID: 20637254

Article Published Date : Oct 09, 2008

Study Type : Animal Study

Additional Links

Substances : Bee Propolis : CK(232) : AC(86)

Diseases : Aluminum Toxicity : CK(98) : AC(36)

Propolis protects against reproductive toxicity caused by aluminium chloride in male rats.

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Pubmed Data : Food Chem Toxicol. 2009 Feb 10. Epub 2009 Feb 10. PMID: 19425234

Article Published Date : Feb 10, 2009

Study Type : Animal Study

Additional Links

Substances : Bee Propolis : CK(232) : AC(86)

Diseases : Aluminum Toxicity : CK(98) : AC(36), Infertility: Male : CK(201) : AC(53)

Vitamin C ameliorates aluminium-induced deterioration in reproductive performance and seminal plasma biochemistry of male rabbits.

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Pubmed Data : Toxicology. 2005 Nov 5;215(1-2):97-107. Epub 2005 Aug 10. PMID: 16098653

Article Published Date : Nov 05, 2005

Study Type : Animal Study

Additional Links

Substances : Vitamin C : CK(1178) : AC(238)

Diseases : Aluminum Toxicity : CK(98) : AC(36), Sperm Quality: Low : CK(150) : AC(28)

Pharmacological Actions : Antioxidants : CK(3503) : AC(1292)

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Toxic...and Don't Know?

Written by Capt. Randall

Ever since humans discovered fire, our activities have been releasing a "dog's breakfast" of unnatural chemistry. The list has grown to well over 75,000 free elements, compounds and pharmaceuticals. Many of these are acidic, electron-hungry oxidants and free radical generators.

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