Alzheimer's Disease

Alzheimer's Disease

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Neurodegenerative Diseases

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Quick Summary: Current access displays 2 out of 97 associated Substances

Name	Cumulative Knowledge	Article Count	Focus Articles
Curcumin	63	30	Log in \| Sign up
Folic Acid	45	7	Log in \| Sign up

Quick Summary: Current access displays 2 out of 13 associated Problem Substances

Name	Cumulative Knowledge	Article Count	Focus Articles
Donepezil (trade name Aricept)	63	5	Log in \| Sign up
Memantine	42	3	Log in \| Sign up

Quick Summary: Current access displays 2 out of 4 associated Therapeutic Actions

Name	Cumulative Knowledge	Article Count	Focus Articles
Dietary Modification: Mediterranean Diet	10	1	Log in \| Sign up
Massage/Therapeutic Touch	10	1	Log in \| Sign up

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View the Evidence: Ailments

21 percent of patients who receive donepezil discontinue treatment due to adverse side effects.

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Pubmed Data : Ugeskr Laeger. 2009 Dec 7;171(50):3690-3. PMID: 20003864

Article Published Date : Dec 07, 2009

Study Type : Meta Analysis

Additional Links

Diseases : Alzheimer's Disease : CK(837) : AC(165), Diarrhea: Drug-Associated : CK(22) : AC(2)

Problem Substances : Donepezil (trade name Aricept) : CK(89) : AC(8)

Cholinesterase inhibitor drug use is associated with increased incidence of bradycardia.

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Pubmed Data : J Am Geriatr Soc. 2009 Nov;57(11):1997-2003. Epub 2009 Sep 28. PMID: 19793162

Article Published Date : Nov 01, 2009

Study Type : Meta Analysis

Additional Links

Diseases : Alzheimer's Disease : CK(837) : AC(165), Bradycardia : CK(56) : AC(8), Dementia : CK(207) : AC(31)

Problem Substances : Cholinesterase Inhibitor Drugs : CK(135) : AC(9), Donepezil (trade name Aricept) : CK(89) : AC(8)

Donepezil and memantine are known to cause bradycardia and to reduce the epileptogenic threshold.

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Pubmed Data : Therapie. 2010 May-Jun;65(3):255-9. Epub 2010 Aug 11. PMID: 20699079

Article Published Date : May 01, 2010

Study Type : Meta Analysis

Additional Links

Diseases : Alzheimer's Disease : CK(837) : AC(165), Bradycardia : CK(56) : AC(8), Epileptic Seizures : CK(47) : AC(6)

Problem Substances : Donepezil (trade name Aricept) : CK(89) : AC(8), Memantine : CK(42) : AC(3)

Memantine does not appear to have proven benefit for mild to moderate alzheimer disease.

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Pubmed Data : Cochrane Database Syst Rev. 2005(3):CD003154. Epub 2005 Jul 20. PMID: 16034889

Article Published Date : Jan 01, 2005

Study Type : Meta Analysis

Additional Links

Diseases : Alzheimer's Disease : CK(837) : AC(165), Dementia : CK(207) : AC(31)

Problem Substances : Memantine : CK(42) : AC(3)

A high adherence to the Mediterranean diet has been associated with slower cognitive decline, with reduced risk of mild cognitive impairment conversion to Alzheimer's disease and with reduced risk of Alzheimer's disease.

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Pubmed Data : Indian J Physiol Pharmacol. 2006 Jul-Sep;50(3):241-9. PMID: 18635428

Article Published Date : Jul 01, 2006

Study Type : Human Study

Additional Links

Diseases : Alzheimer's Disease : CK(837) : AC(165), Cognitive Decline/Dysfunction : CK(514) : AC(87)

Therapeutic Actions : Dietary Modification: Mediterranean Diet : CK(492) : AC(57)

Additional Keywords : Risk Reduction : CK(1943) : AC(195)

A multi-vitamin/nutrient formula has therapeutic value in early-stage Alzheimer's diease.

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Pubmed Data : Am J Alzheimers Dis Other Demen. 2008 Dec-2009 Jan;23(6):571-85. Epub 2008 Dec 1. PMID: 19047474

Article Published Date : Dec 01, 2008

Study Type : Human Study

Additional Links

Substances : Carnitine, Acetyl-L- : CK(40) : AC(4), Folic Acid : CK(572) : AC(77), NAC (N-acetyl-L-cysteine) : CK(258) : AC(62), SAMe (S-adenosylmethionine) : CK(89) : AC(17), Vitamin B-6 : CK(412) : AC(48), Vitamin E : CK(1290) : AC(218)

Diseases : Alzheimer's Disease : CK(837) : AC(165)

A multi-vitamin/nutrient formula has therapeutic value in moderate-stage to later-stage Alzheimer's diease.

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Pubmed Data : Am J Alzheimers Dis Other Demen. 2009 Feb-Mar;24(1):27-33. Epub 2008 Dec 3. PMID: 19056706

Article Published Date : Feb 01, 2009

Study Type : Human Study

Additional Links

Substances : Carnitine, Acetyl-L- : CK(40) : AC(4), Folic Acid : CK(572) : AC(77), NAC (N-acetyl-L-cysteine) : CK(258) : AC(62), SAMe (S-adenosylmethionine) : CK(89) : AC(17), Vitamin B-12 : CK(752) : AC(94), Vitamin E : CK(1290) : AC(218)

Diseases : Alzheimer's Disease : CK(837) : AC(165)

Alpha lipoic acid is an anti-inflammatory and neuroprotective treatment for Alzheimer's disease.

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Pubmed Data : Adv Drug Deliv Rev. 2008 Oct-Nov;60(13-14):1463-70. Epub 2008 Jul 4. PMID: 18655815

Article Published Date : Oct 01, 2008

Study Type : Human Study

Additional Links

Substances : Alpha-Lipoic Acid : CK(408) : AC(80)

Diseases : Alzheimer's Disease : CK(837) : AC(165)

Pharmacological Actions : Neuroprotective Agents : CK(921) : AC(464)

Alpha-GPC improves cognitive function in mild to moderate Alzhemier's dementia.

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Pubmed Data : Clin Ther. 2003 Jan;25(1):178-93. PMID: 12637119

Article Published Date : Jan 01, 2003

Study Type : Human Study

Additional Links

Substances : GlyceroPhosphoCholine (alpha-GPC) : CK(12) : AC(7)

Diseases : Alzheimer's Disease : CK(837) : AC(165)

Apha lipoic appears to be an effective neuroprotective agent in Alzheimer's disease.

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Pubmed Data : J Neural Transm Suppl. 2007;(72):189-93. PMID: 17982894

Article Published Date : Jan 01, 2007

Study Type : Human Study

Additional Links

Substances : Alpha-Lipoic Acid : CK(408) : AC(80)

Diseases : Alzheimer's Disease : CK(837) : AC(165)

Pharmacological Actions : Neuroprotective Agents : CK(921) : AC(464)

B vitamins appear to slow cognitive and clinical decline in people with mild cognitive impairment, in particular in those with elevated homocysteine.

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Pubmed Data : Int J Geriatr Psychiatry. 2011 Jul 21. Epub 2011 Jul 21. PMID: 21780182

Article Published Date : Jul 21, 2011

Study Type : Human Study

Additional Links

Substances : Folic Acid : CK(572) : AC(77), Vitamin B-12 : CK(752) : AC(94), Vitamin B-6 : CK(412) : AC(48)

Diseases : Alzheimer's Disease : CK(837) : AC(165), Cognitive Decline/Dysfunction : CK(514) : AC(87), High Homocysteine : CK(368) : AC(57), Neurodegenerative Diseases : CK(1701) : AC(420)

Pharmacological Actions : Neuroprotective Agents : CK(921) : AC(464)

Caffeine in coffee can prevent and help brain function in Alzheimer's Disease

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Article Publish Status : This is a free article. Click here to read the entire article.

Pubmed Data : Curr Neuropharmacol. 2009 Sep ;7(3):207-16. PMID: 20190962

Article Published Date : Sep 01, 2009

Study Type : Human Study, Review, Transgenic Animal Study

Additional Links

Substances : Caffeine : CK(109) : AC(18), Coffee : CK(352) : AC(52)

Diseases : Alzheimer's Disease : CK(837) : AC(165)

Chronic consumption of proton pump inhibitors may increase the risk for Alzheimer disease.

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Pubmed Data : J Clin Pharm Ther. 2010 Apr;35(2):125-6. PMID: 20456731

Article Published Date : Apr 01, 2010

Study Type : Human Study

Additional Links

Diseases : Alzheimer's Disease : CK(837) : AC(165), Brain: Microglial Activation : CK(64) : AC(38), Neurodegenerative Diseases : CK(1701) : AC(420)

Adverse Pharmacological Actions : Neurotoxic : CK(1042) : AC(170)

Cocoa procyanidins attenuate lipid peroxidation associated neuronal cell death in a manner relevant to Alzheimer's disease.

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Pubmed Data : Free Radic Biol Med. 2009 May 15;46(10):1319-27. Epub 2009 Feb 25. PMID: 19248828

Article Published Date : May 15, 2009

Study Type : Human Study

Additional Links

Substances : Catechin : CK(408) : AC(130), Cocoa : CK(502) : AC(43)

Diseases : Alzheimer's Disease : CK(837) : AC(165), Neurodegenerative Diseases : CK(1701) : AC(420), Oxidative Stress : CK(1867) : AC(710)

Pharmacological Actions : Anti-Apoptotic : CK(59) : AC(39), Antioxidants : CK(3503) : AC(1292)

Additional Keywords : Proanthocyanidins : CK(159) : AC(46)

Curcumin appears to enhance clearance of amyloid-beta in Alzheimer's disease patients.

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Pubmed Data : J Alzheimers Dis. 2006 Sep;10(1):1-7. PMID: 16988474

Article Published Date : Sep 01, 2006

Study Type : Human Study

Additional Links

Substances : Curcumin : CK(2890) : AC(1511)

Diseases : Alzheimer's Disease : CK(837) : AC(165)

Additional Keywords : Disease Regression : CK(138) : AC(20)

Folic acid deficiency may play a key role in neurodegenerative disorders.

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Pubmed Data : Neurosci Lett. 2007 Jun 15;420(3):213-6. Epub 2007 May 3. PMID: 17532571

Article Published Date : Jun 15, 2007

Study Type : Human Study

Additional Links

Substances : Folic Acid : CK(572) : AC(77)

Diseases : Alzheimer's Disease : CK(837) : AC(165), Dementia : CK(207) : AC(31), Lewy Body Disease : CK(10) : AC(1)

Gingko biloba compares favorably to the drug Aricept (donepezil) for the treatment of Alzheimer's dementia.

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Pubmed Data : Eur J Neurol. 2006 Sep;13(9):981-5. PMID: 16930364

Article Published Date : Sep 01, 2006

Study Type : Human Study

Additional Links

Substances : Ginkgo biloba : CK(511) : AC(97), Piperidines : CK(45) : AC(17)

Diseases : Alzheimer's Disease : CK(837) : AC(165), Dementia : CK(207) : AC(31)

Additional Keywords : Donepezil Alternatives : CK(20) : AC(2), Natural Substances Versus Drugs : CK(1043) : AC(159), Plant Extracts : CK(3401) : AC(1158)

Ginkgo biloba is as effective as the drug donepezil (Aricept) in improving symptoms of Alzheimers, but with less side effects.

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Pubmed Data : Aging Ment Health. 2009 Mar;13(2):183-90. PMID: 19347685

Article Published Date : Mar 01, 2009

Study Type : Human Study

Additional Links

Substances : Ginkgo biloba : CK(511) : AC(97)

Diseases : Alzheimer's Disease : CK(837) : AC(165)

Additional Keywords : Superiority of Natural Substances versus Drugs : CK(897) : AC(158)

High homocysteine levels may be associated with the pathogenesis of neurological disorders.

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Pubmed Data : Front Biosci (Schol Ed). 2010;2:359-72. Epub 2010 Jan 1. PMID: 20036953

Article Published Date : Jan 01, 2010

Study Type : Human Study

Additional Links

Substances : B-complex : CK(278) : AC(32)

Diseases : Alzheimer's Disease : CK(837) : AC(165), Amyotrophic Lateral Sclerosis : CK(350) : AC(68), Epilepsy : CK(128) : AC(27), High Homocysteine : CK(368) : AC(57), Hyperhomocysteinemia : CK(368) : AC(57), Multiple Sclerosis : CK(706) : AC(133), Parkinson Disease : CK(541) : AC(79), Stroke : CK(539) : AC(46)

Additional Keywords : Diseases that are Linked : CK(2162) : AC(265)

High intake of polyunsaturated fatty acids (PUFA) and monounsaturated fatty acids (MUFA) reduce the risk of cognitive decline and dementia associated with Alzheimer's disease and/or vascular dsyfunction.

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Pubmed Data : Exp Gerontol. 2005 Apr;40(4):257-70. PMID: 15820606

Article Published Date : Apr 01, 2005

Study Type : Human Study

Additional Links

Substances : Monounsaturated fatty acids : CK(50) : AC(5), Omega-3 Fatty Acids : CK(3255) : AC(319), Polyunsaturated Fatty Acids (PUFAs) : CK(98) : AC(14)

Diseases : Alzheimer's Disease : CK(837) : AC(165), Cerebrovascular Disorders : CK(10) : AC(1)

Additional Keywords : Risk Reduction : CK(1943) : AC(195)

Higher intake of hydrogenated fats may increase the risk of Alzheimer disease.

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Pubmed Data : Arch Neurol. 2003 Feb;60(2):194-200. PMID: 12580703

Article Published Date : Feb 01, 2003

Study Type : Human Study

Additional Links

Diseases : Alzheimer's Disease : CK(837) : AC(165)

Problem Substances : Hydrogenated Oil : CK(158) : AC(23)

Higher intake of polyunsaturated fatty acids (PUFA) and fish oil was associated with better semantic memory and global cognitive function.

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Pubmed Data : Int J Geriatr Psychiatry. 2008 Jul;23(7):741-7. PMID: 18188871

Article Published Date : Jul 01, 2008

Study Type : Human Study

Additional Links

Substances : Polyunsaturated Fatty Acids (PUFAs) : CK(98) : AC(14)

Diseases : Alzheimer's Disease : CK(837) : AC(165), Cognitive Decline/Dysfunction : CK(514) : AC(87)

Medium Chain Triglycerides (coconut fat) increase cognitive performance in Alzheimer's disease.

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Pubmed Data : J Agric Food Chem. 2006 Mar 22;54(6):2123-8. PMID: 15123336

Article Published Date : Mar 22, 2006

Study Type : Human Study

Additional Links

Substances : Coconut : CK(124) : AC(35), Coconut Oil : CK(75) : AC(18), Medium Chain Triglycerides : CK(46) : AC(12)

Diseases : Alzheimer's Disease : CK(837) : AC(165), Cognitive Decline/Dysfunction : CK(514) : AC(87)

Melissa officinalis extract has a therapeutic effect on patients with mild to moderate Alzheimer's disease.

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Pubmed Data : J Neurol Neurosurg Psychiatry. 2003 Jul;74(7):863-6. PMID: 12810768

Article Published Date : Jul 01, 2003

Study Type : Human Study

Additional Links

Substances : Melissa (Lemonbalm) : CK(78) : AC(14)

Diseases : Alzheimer's Disease : CK(837) : AC(165)

Additional Keywords : Plant Extracts : CK(3401) : AC(1158)

Music therapy has a positive effect in treating anxiety and depression in patients suffering from Alzheimer's disease.

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Pubmed Data : Encephale. 2009 Feb;35(1):57-65. Epub 2008 Feb 20. PMID: 19250995

Article Published Date : Feb 01, 2009

Study Type : Human Study

Additional Links

Diseases : Alzheimer's Disease : CK(837) : AC(165)

Therapeutic Actions : Music : CK(317) : AC(33)

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