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Amyotrophic Lateral Sclerosis
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Additional Topics Details for this Page
Article Count
- 68
Cumulative Knowledge
- 350
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Amyotrophic Lateral Sclerosis is a Sub of the following Topics
Autoimmune Diseases
Demyelinating Diseases
Neurodegenerative Diseases
What is Cumulative Knowledge?
Cumulative Knowledge
is determined by ascribing a numerical value to the various study types weighted in descending order as follows: (1) Meta-Analysis; (2) Human Study; (3) Human: Case Study; (4) Animal: Transgenic; (5) Animal; (6) In Vitro; (7) Review; and (8) Commentary.
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Quick Summary: Current access displays 2 out of 39 associated Substances
Name
Cumulative Knowledge
Article Count
Focus Articles
Coenzyme Q10
23
4
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Vitamin E
23
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Quick Summary: Current access displays 2 out of 8 associated Problem Substances
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Lead
25
4
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Pesticides
20
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Quick Summary: 1 associated Therapeutic Actions
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Exercise
14
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Electromagnetic Fields
20
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View the Evidence: Ailments
There is an association between occupational exposure to power frequency electromagnetic fields and amyotrophic lateral sclerosis.
Click here to read the entire abstract
Pubmed Data
: Am J Ind Med. 2003 Feb;43(2):212-20. PMID:
12541277
Article Published Date
: Feb 01, 2003
Study Type
: Meta Analysis
Additional Links
Diseases
:
Amyotrophic Lateral Sclerosis : CK(350) : AC(68)
Anti Therapeutic Actions
:
Electromagnetic Fields : CK(103) : AC(14)
A high intake of poluunsaturated fatty acids and vitamin E is associated with a 50-60% decreased risk of developing ALS.
Click here to read the entire abstract
Pubmed Data
: J Neurol Neurosurg Psychiatry. 2007 Apr;78(4):367-71. Epub 2006 Apr 28. PMID:
16648143
Article Published Date
: Apr 01, 2007
Study Type
: Human Study
Additional Links
Substances
:
Polyunsaturated Fatty Acids (PUFAs) : CK(98) : AC(14)
,
Vitamin E : CK(1285) : AC(221)
Diseases
:
Amyotrophic Lateral Sclerosis : CK(350) : AC(68)
A higher intake of food rich in antioxidants such as fruit and vegetables confer protection against the development of ALS.
Click here to read the entire abstract
Pubmed Data
: Life Sci. 2003 Dec 19;74(5):663-73. PMID:
19209004
Article Published Date
: Dec 19, 2003
Study Type
: Human Study
Additional Links
Substances
:
Fruit: All : CK(1836) : AC(472)
,
Vegetables: All : CK(551) : AC(69)
Diseases
:
Amyotrophic Lateral Sclerosis : CK(350) : AC(68)
Cigarette smoking is associated with increased risk for ALS.
Click here to read the entire abstract
Pubmed Data
: Neuroepidemiology. 1999;18(4):194-202. PMID:
10364720
Article Published Date
: Jan 01, 1999
Study Type
: Human Study
Additional Links
Diseases
:
Amyotrophic Lateral Sclerosis : CK(350) : AC(68)
,
Smoking : CK(577) : AC(86)
Problem Substances
:
Tobacco : CK(74) : AC(7)
Adverse Pharmacological Actions
:
Neurotoxic : CK(1076) : AC(179)
Coenzyme Q10 levels as high as 3,000 mg a day are safe and well-tolerated in ALS patients.
Click here to read the entire abstract
Pubmed Data
: Neurology. 2005 Dec 13;65(11):1834-6. PMID:
16344537
Article Published Date
: Dec 13, 2005
Study Type
: Human Study
Additional Links
Substances
:
Coenzyme Q10 : CK(667) : AC(104)
Diseases
:
Amyotrophic Lateral Sclerosis : CK(350) : AC(68)
Pharmacological Actions
:
Antioxidants : CK(3653) : AC(1318)
,
Neuroprotective Agents : CK(962) : AC(480)
Free testosterone is significantly decreased in ALS, indicating that supplementation with testosterone may have a therapeutic role in ALS treatment.
Click here to read the entire abstract
Pubmed Data
: J Neurol Sci. 2002 Mar 15;195(1):67-70. PMID:
11867076
Article Published Date
: Mar 15, 2002
Study Type
: Human Study
Additional Links
Substances
:
Testosterone : CK(134) : AC(26)
Diseases
:
Amyotrophic Lateral Sclerosis : CK(350) : AC(68)
Glutamate levels may contribute to the pathogenesis of ALS.
Click here to read the entire abstract
Pubmed Data
: Acta Neurol Scand. 2010 Feb;121(2):120-6. Epub 2009 Oct 5. PMID:
19804473
Article Published Date
: Feb 01, 2010
Study Type
: Human Study
Additional Links
Diseases
:
Amyotrophic Lateral Sclerosis : CK(350) : AC(68)
Problem Substances
:
L-glutamic Acid : CK(11) : AC(2)
,
Monosodium Glutamate (MSG) : CK(39) : AC(12)
Adverse Pharmacological Actions
:
Excitotoxic : CK(10) : AC(1)
High homocysteine levels are associated with neurodegenerative conditions such as Parkinson's disease, ALS and progressive supranuclear palsy.
Click here to read the entire abstract
Pubmed Data
: Dement Geriatr Cogn Disord. 2010 Jul;29(6):553-9. Epub 2010 Jul 3. PMID:
20606437
Article Published Date
: Jul 01, 2010
Study Type
: Human Study
Additional Links
Diseases
:
Amyotrophic Lateral Sclerosis : CK(350) : AC(68)
,
Hyperhomocysteinemia : CK(377) : AC(57)
,
Parkinson Disease : CK(543) : AC(79)
,
Supranuclear Palsy: Progressive : CK(10) : AC(1)
Additional Keywords
:
Diseases that are Linked : CK(2122) : AC(270)
High homocysteine levels may be associated with the pathogenesis of neurological disorders.
Click here to read the entire abstract
Pubmed Data
: Front Biosci (Schol Ed). 2010;2:359-72. Epub 2010 Jan 1. PMID:
20036953
Article Published Date
: Jan 01, 2010
Study Type
: Human Study
Additional Links
Substances
:
B-complex : CK(278) : AC(32)
Diseases
:
Alzheimer's Disease : CK(826) : AC(160)
,
Amyotrophic Lateral Sclerosis : CK(350) : AC(68)
,
Epilepsy : CK(128) : AC(27)
,
High Homocysteine : CK(368) : AC(57)
,
Hyperhomocysteinemia : CK(377) : AC(57)
,
Multiple Sclerosis : CK(716) : AC(133)
,
Parkinson Disease : CK(543) : AC(79)
,
Stroke : CK(540) : AC(47)
Additional Keywords
:
Diseases that are Linked : CK(2122) : AC(270)
It is possible that lesions suggestive of Amyotrophic Lateral Sclerosis may be attributed to celiac disease.
Click here to read the entire abstract
Pubmed Data
: BJU Int. 2007 Mar;99(3):619-22. Epub 2006 Nov 28. PMID:
19910450
Article Published Date
: Mar 01, 2007
Study Type
: Human Study
Additional Links
Diseases
:
Amyotrophic Lateral Sclerosis : CK(350) : AC(68)
,
Autoimmune Diseases : CK(5317) : AC(779)
,
Celiac Disease : CK(1527) : AC(215)
Lead exposure is a risk factor for amyotrophic lateral sclerosis.
Click here to read the entire abstract
Pubmed Data
: Neurodegener Dis. 2005;2(3-4):195-201. PMID:
16909025
Article Published Date
: Jan 01, 2005
Study Type
: Human Study
Additional Links
Diseases
:
Amyotrophic Lateral Sclerosis : CK(350) : AC(68)
Problem Substances
:
Lead : CK(97) : AC(15)
Methylcobalamin may prevent muscle wasting in amyotrophic lateral sclerosis.
Click here to read the entire abstract
Pubmed Data
: Muscle Nerve. 1998 Dec;21(12):1775-8. PMID:
9843082
Article Published Date
: Dec 01, 1998
Study Type
: Human Study
Additional Links
Substances
:
Vitamin B12: methylcobalamin : CK(55) : AC(9)
,
Vitamin B-12 : CK(752) : AC(94)
Diseases
:
Amyotrophic Lateral Sclerosis : CK(350) : AC(68)
Occupational exposures to agricultural chemicals is associated with increased risk for ALS.
Click here to read the entire abstract
Pubmed Data
: Am J Epidemiol. 1997 Jun 15;145(12):1076-88. PMID:
9199537
Article Published Date
: Jun 15, 1997
Study Type
: Human Study
Additional Links
Diseases
:
Amyotrophic Lateral Sclerosis : CK(350) : AC(68)
Problem Substances
:
Agricultural Chemicals : CK(10) : AC(1)
,
Pesticides : CK(699) : AC(70)
Adverse Pharmacological Actions
:
Neurotoxic : CK(1076) : AC(179)
Pesticide exposure is associated with an increased risk of amyotrophic lateral sclerosis.
Click here to read the entire abstract
Pubmed Data
: Ann Ist Super Sanita. 2010;46(3):284-7. PMID:
20847462
Article Published Date
: Jan 01, 2010
Study Type
: Human Study
Additional Links
Diseases
:
Amyotrophic Lateral Sclerosis : CK(350) : AC(68)
Problem Substances
:
Pesticides : CK(699) : AC(70)
Adverse Pharmacological Actions
:
Neurotoxic : CK(1076) : AC(179)
Progesterone levels correlate positively with survival and prognosis in ALS patients.
Click here to read the entire abstract
Pubmed Data
: Acta Neurol Scand. 2011 Jan;123(1):60-7. PMID:
20545634
Article Published Date
: Jan 01, 2011
Study Type
: Human Study
Additional Links
Substances
:
Progesterone : CK(70) : AC(26)
Diseases
:
Amyotrophic Lateral Sclerosis : CK(350) : AC(68)
Pharmacological Actions
:
Neuroprotective Agents : CK(962) : AC(480)
Selenium, glutathione, copper/zinc and superoxide dismutase may have therapeutic value in ALS.
Click here to read the entire abstract
Pubmed Data
: Scand J Rheumatol. 1995;24(2):85-93. PMID:
9726810
Article Published Date
: Jan 01, 1995
Study Type
: Human Study
Additional Links
Substances
:
Antioxidant formulas : CK(487) : AC(73)
,
Copper : CK(82) : AC(16)
,
Glutathione : CK(61) : AC(16)
,
Selenium : CK(574) : AC(94)
,
Superoxide dismutase : CK(16) : AC(5)
,
Zinc : CK(870) : AC(127)
Diseases
:
Amyotrophic Lateral Sclerosis : CK(350) : AC(68)
Pharmacological Actions
:
Calcium Channel Blockers : CK(86) : AC(21)
Statin drug use may be linked to neuromuscular diseases and an amyotrophic lateral sclerosis-like syndrome.
Click here to read the entire abstract
Pubmed Data
: Drug Saf. 2007;30(6):515-25. PMID:
17536877
Article Published Date
: Jan 01, 2007
Study Type
: Human Study
Additional Links
Diseases
:
Amyotrophic Lateral Sclerosis : CK(350) : AC(68)
,
Neuromuscular Diseases : CK(16) : AC(4)
Problem Substances
:
Statin Drugs : CK(3969) : AC(465)
Statin drugs may cause ALS-like neurodegeneration in susceptible individuals.
Click here to read the entire abstract
Pubmed Data
: Drug Saf. 2009;32(8):649-61. PMID:
19591530
Article Published Date
: Jan 01, 2009
Study Type
: Human Study
Additional Links
Diseases
:
Amyotrophic Lateral Sclerosis : CK(350) : AC(68)
,
Neurodegenerative Diseases : CK(1743) : AC(420)
,
Oxidative Stress : CK(1945) : AC(710)
Problem Substances
:
Statin Drugs : CK(3969) : AC(465)
There is an association between blood lead and the risk of amyotrophic lateral sclerosis.
Click here to read the entire abstract
Pubmed Data
: Am J Epidemiol. 2010 May 15;171(10):1126-33. Epub 2010 Apr 20. PMID:
20406759
Article Published Date
: May 15, 2010
Study Type
: Human Study
Additional Links
Diseases
:
Amyotrophic Lateral Sclerosis : CK(350) : AC(68)
,
Lead Poisoning : CK(173) : AC(34)
Problem Substances
:
Lead : CK(97) : AC(15)
There is increased mitochondrial oxidative damage in patients with sporadic amyotrophic lateral sclerosis
Click here to read the entire abstract
Pubmed Data
: J Neurol Sci. 2008 Apr 15;267(1-2):66-9. Epub 2007 Oct 24. PMID:
17961597
Article Published Date
: Apr 15, 2008
Study Type
: Human Study
Additional Links
Substances
:
Coenzyme Q10 : CK(667) : AC(104)
Diseases
:
Amyotrophic Lateral Sclerosis : CK(350) : AC(68)
,
Mitochondrial Diseases : CK(149) : AC(50)
,
Oxidative Stress : CK(1945) : AC(710)
Additional Keywords
:
Diseases that are Linked : CK(2122) : AC(270)
Tobacco consumption is associated with increased risk for ALS.
Click here to read the entire abstract
Pubmed Data
: Am J Epidemiol. 2000 Jan 15;151(2):156-63. PMID:
10645818
Article Published Date
: Jan 15, 2000
Study Type
: Human Study
Additional Links
Diseases
:
Amyotrophic Lateral Sclerosis : CK(350) : AC(68)
,
Nicotine/Tobacco Toxicity : CK(152) : AC(26)
,
Smoking : CK(577) : AC(86)
Problem Substances
:
Nicotine : CK(56) : AC(8)
,
Tobacco : CK(74) : AC(7)
Adverse Pharmacological Actions
:
Neurotoxic : CK(1076) : AC(179)
Treadmill ambulation is feasible, tolerated and safe for patients for amyotrophic lateral sclerosis.
Click here to read the entire abstract
Pubmed Data
: Arch Phys Med Rehabil. 2010 Dec;91(12):1920-9. PMID:
21112435
Article Published Date
: Dec 01, 2010
Study Type
: Human Study
Additional Links
Diseases
:
Amyotrophic Lateral Sclerosis : CK(350) : AC(68)
Therapeutic Actions
:
Exercise : CK(482) : AC(69)
Vitamin B12 as methylcobalamin significantly prolongs survival time in Amyotrophic Lateral Sclerosis.
Click here to read the entire abstract
Pubmed Data
: Brain Nerve. 2007 Oct;59(10):1141-7. PMID:
17969354
Article Published Date
: Oct 01, 2007
Study Type
: Human Study
Additional Links
Substances
:
Vitamin B12: methylcobalamin : CK(55) : AC(9)
,
Vitamin B-12 : CK(752) : AC(94)
Diseases
:
Amyotrophic Lateral Sclerosis : CK(350) : AC(68)
Vitamin E supplementation may contribute to preventing amyotrophic lateral sclerosis.
Click here to read the entire abstract
Pubmed Data
: Ann Neurol. 2005 Jan;57(1):104-10. PMID:
15529299
Article Published Date
: Jan 01, 2005
Study Type
: Human Study
Additional Links
Substances
:
Vitamin E : CK(1285) : AC(221)
Diseases
:
Amyotrophic Lateral Sclerosis : CK(350) : AC(68)
Whey protein improves the condition of patients with amyotrophic lateral sclerosis.
Click here to read the entire abstract
Pubmed Data
: Arq Neuropsiquiatr. 2010 Apr;68(2):263-8. PMID:
20464297
Article Published Date
: Apr 01, 2010
Study Type
: Human Study
Additional Links
Substances
:
Whey : CK(323) : AC(72)
Diseases
:
Amyotrophic Lateral Sclerosis : CK(350) : AC(68)
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