Arthritis

Arthritis


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View the Evidence: Ailments

Boswellia's immunomodulatory properties may make it ideal for the treatment of autoimmune and inflammatory diseases.

Pubmed Data : Phytomedicine. 2010 Sep;17(11):862-7. Epub 2010 Aug 8. PMID: 20696559
Article Published Date : Sep 01, 2010
Study Type : Review
Additional Links
Substances : Boswellia : CK(122) : AC(31)
Diseases : Arthritis: Rheumatoid : CK(289) : AC(54), Asthma: Bronchial : CK(267) : AC(33), Autoimmune Diseases : CK(5317) : AC(779), Colitis: Ulcerative : CK(139) : AC(18), Crohn's Disease : CK(122) : AC(22), Inflammatory Bowel Diseases : CK(1227) : AC(103), Osteoarthritis : CK(615) : AC(91)
Pharmacological Actions : Interleukin-1 alpha downregulation : CK(34) : AC(12), Interleukin-2 Downregulation : CK(4) : AC(3), Interleukin-4 downregulation : CK(37) : AC(12), Interleukin-6 Downregulation : CK(470) : AC(135), Leukotriene Antagonists : CK(38) : AC(9), NF-kappaB Inhibitor : CK(595) : AC(401), Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

Calcium phosphate crystal formation is associated with the promotion of articular tissue degradation in osteoarthritis.

Pubmed Data : Biochem Biophys Res Commun. 2007 Apr 13;355(3):654-60. Epub 2007 Feb 7. PMID: 17307136
Article Published Date : Apr 13, 2007
Study Type : In Vitro Study
Additional Links
Diseases : Osteoarthritis : CK(615) : AC(91)

Curcumin (from Turmeric) inhibits autoimmune diseases.

Pubmed Data : Adv Exp Med Biol. 2007;595:425-51. PMID: 17569223
Article Published Date : Jan 01, 2007
Study Type : Commentary
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Arthritis: Rheumatoid : CK(289) : AC(54), Autoimmune Diseases : CK(5317) : AC(779), Inflammatory Bowel Diseases : CK(1227) : AC(103), Multiple Sclerosis : CK(716) : AC(133), Myasthenia Gravis : CK(82) : AC(14), Psoriasis : CK(270) : AC(42)
Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

Curcumin and quercetin inhibit inflammatory processes associated with arthritis.

Pubmed Data : Inflamm Res. 2006 Apr;55(4):168-75. PMID: 16807698
Article Published Date : Apr 01, 2006
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482), Quercetin : CK(318) : AC(136)
Diseases : Arthritis : CK(1430) : AC(218), Arthritis: Rheumatoid : CK(289) : AC(54), Inflammation : CK(1077) : AC(363)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Antioxidants : CK(3653) : AC(1318), Antiproliferative : CK(1052) : AC(775), Apoptotic : CK(1489) : AC(1114)

Curcumin and resveratrol have a synergistic chondroprotective effect in human articular chondrocytes.

Pubmed Data : Arthritis Res Ther. 2009 Nov 4;11(6):R165. PMID: 19889203
Article Published Date : Nov 04, 2009
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482), Resveratrol : CK(977) : AC(590)
Diseases : Osteoarthritis : CK(615) : AC(91)
Pharmacological Actions : NF-kappaB Inhibitor : CK(595) : AC(401)

Curcumin antagonizes crucial catabolic effects of IL-1beta signaling that are known to contribute to the pathogenesis of osteoarthritis.

Pubmed Data : Ann N Y Acad Sci. 2004 Dec;1030:578-86. PMID: 15659840
Article Published Date : Dec 01, 2004
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Osteoarthritis : CK(615) : AC(91)
Pharmacological Actions : NF-kappaB Inhibitor : CK(595) : AC(401)

Curcumin displays therapeutic properties in an experimental model of osteoarthritis.

Pubmed Data : Ann N Y Acad Sci. 2009 Aug;1171:428-35. PMID: 19723086
Article Published Date : Aug 01, 2009
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Osteoarthritis : CK(615) : AC(91)
Pharmacological Actions : Interleukin-1 beta downregulation : CK(177) : AC(70)

Curcumin exerts anti-apoptotic and anti-catabolic effects on IL-1beta-stimulated articular chondrocytes, indicating is may have therapeutic value in the treatment of osteoarthritis and related osteoarticular disorders.

Pubmed Data : Ann Anat. 2005 Nov;187(5-6):487-97. PMID: 16320828
Article Published Date : Nov 01, 2005
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Osteoarthritis : CK(615) : AC(91)
Pharmacological Actions : Anti-Apoptotic : CK(59) : AC(39), Enzyme Inhibitors : CK(372) : AC(208), Interleukin-1 beta downregulation : CK(177) : AC(70)

Curcumin exhibits anti-rheumatoid activity.

Pubmed Data : Eur J Pharmacol. 2009 Jun 10;612(1-3):161-6. Epub 2009 Apr 14. PMID: 19371737
Article Published Date : Jun 10, 2009
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Arthritis: Rheumatoid : CK(289) : AC(54)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433)

Curcumin has nutritional potential as a naturally occurring anti-inflammatory agent for treating osteoarthritis.

Pubmed Data : Biochem Pharmacol. 2007 May 1;73(9):1434-45. Epub 2007 Jan 7. PMID: 17291458
Article Published Date : May 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Osteoarthritis : CK(615) : AC(91)
Pharmacological Actions : Cyclooxygenase 2 Inhibitors : CK(269) : AC(169), Matrix metalloproteinase-2 (MMP-2) inhibitor : CK(153) : AC(71), NF-kappaB Inhibitor : CK(595) : AC(401)

Curcumin may have a therapeutic role in the treatment of osteoarthritis.

Pubmed Data : Osteoarthritis Cartilage. 2010 Feb;18(2):141-9. Epub 2009 Oct 8. PMID: 19836480
Article Published Date : Feb 01, 2010
Study Type : Review
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Inflammation : CK(1077) : AC(363), Osteoarthritis : CK(615) : AC(91)
Pharmacological Actions : Apoptotic : CK(1489) : AC(1114), Enzyme Inhibitors : CK(372) : AC(208), Interleukin-1 beta downregulation : CK(177) : AC(70), NF-kappaB Inhibitor : CK(595) : AC(401)

Curcumin may support the regeneration of articular cartilage.

Pubmed Data : Arthritis Res Ther. 2010;12(4):R127. Epub 2010 Jul 1. PMID: 20594343
Article Published Date : Jan 01, 2010
Study Type : In Vitro Study
Additional Links
Substances : Curcumin : CK(2910) : AC(1482)
Diseases : Cartilage Diseases : CK(5) : AC(5), Osteoarthritis : CK(615) : AC(91), Rheumatoid Arthritis : CK(424) : AC(64)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433), Apoptotic : CK(1489) : AC(1114), Interleukin-1 beta downregulation : CK(177) : AC(70), NF-kappaB Inhibitor : CK(595) : AC(401)

Do dietary lectins cause disease?

Article Publish Status : This is a free article. Click here to read the complete article.
Pubmed Data : BMJ. 1999 Apr 17 ;318(7190):1023-4. PMID: 10205084
Article Published Date : Apr 16, 1999
Study Type : Review
Additional Links
Diseases : Rheumatoid Arthritis : CK(424) : AC(64)
Additional Keywords : Lectins : CK(58) : AC(36)
Problem Substances : Wheat Germ Agglutinin (WGA) : CK(821) : AC(39)

EGCG, a green tea polyphenol, induces programmed cell death in rheumatoid arthritis synovial fibroblasts.

Pubmed Data : Am J Surg. 2010 Jul 7. Epub 2010 Jul 7. PMID: 19404960
Article Published Date : Jul 07, 2010
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(859) : AC(109)
Diseases : Arthritis: Rheumatoid : CK(289) : AC(54), Rheumatoid Arthritis : CK(424) : AC(64)

EGCG, a green tea polyphenol, may play a role in regulating inflammation and bone destruction in RA patients.

Pubmed Data : Gastroenterology. 2007 May;132(5):1925-36. Epub 2007 Feb 21. PMID: 18496696
Article Published Date : May 01, 2007
Study Type : In Vitro Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(859) : AC(109)
Diseases : Arthritis: Rheumatoid : CK(289) : AC(54), Rheumatoid Arthritis : CK(424) : AC(64)
Pharmacological Actions : Tumor Necrosis Factor (TNF) Alpha Inhibitor : CK(971) : AC(348)

Extracts of Perna analiculus (green-lipped mussel) may reduce inflammation and immunoglobulins in autoimmune diseases like lupus and rheumatoid arthritis.

Pubmed Data : Clin Exp Allergy. 2008 Aug;38(8):1282-9. Epub 2008 May 28. PMID: 16412227
Article Published Date : Aug 01, 2008
Study Type : In Vitro Study
Additional Links
Substances : Mussel: Green-lipped (Perna canaliculus) : CK(48) : AC(20)
Diseases : Arthritis: Rheumatoid : CK(289) : AC(54), Lupus Erythematosus: Systemic : CK(949) : AC(53)

Lactoferrin may have a therapeutic role in rhematoid arthritis and cancer.

Pubmed Data : Inflamm Res. 2010 Dec 16. Epub 2010 Dec 16. PMID: 21161563
Article Published Date : Dec 16, 2010
Study Type : In Vitro Study
Additional Links
Substances : Lactoferrin : CK(118) : AC(31)
Diseases : Arthritis: Rheumatoid : CK(289) : AC(54), Cancers: All : CK(9062) : AC(2869)

Lectins bind to inflamed synovial tissue of patients with osteoarthritis and rheumatoid arthritis.

Pubmed Data : Acta Histochem Suppl. 1988;36:277-83. PMID: 3150561
Article Published Date : Jan 01, 1988
Study Type : In Vitro Study
Additional Links
Diseases : Osteoarthritis : CK(615) : AC(91), Rheumatoid Arthritis : CK(424) : AC(64)
Problem Substances : Lectins : CK(35) : AC(27), Wheat Germ Agglutinin (WGA) : CK(821) : AC(39)

Many of the placebo-controlled trials of fish oil in chronic inflammatory diseases reveal significant benefit, including decreased disease activity and a lowered use of anti-inflammatory drugs.

Pubmed Data : J Am Coll Nutr. 2002 Dec ;21(6):495-505. PMID: 12480795
Article Published Date : Nov 30, 2002
Study Type : Review
Additional Links
Substances : DHA (Docosahexaenoic Acid) : CK(582) : AC(100), EPA (Eicosapentaenoic Acid) : CK(595) : AC(84), Fish Oil : CK(615) : AC(95), Omega-3 Fatty Acids : CK(3333) : AC(319)
Diseases : Asthma : CK(918) : AC(134), Cardiovascular Diseases : CK(5138) : AC(641), Inflammation : CK(1077) : AC(363), Inflammatory Bowel Diseases : CK(1227) : AC(103), Psoriasis : CK(270) : AC(42), Rheumatoid Arthritis : CK(424) : AC(64)
Pharmacological Actions : Anti-Inflammatory Agents : CK(1230) : AC(433)

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